SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i36'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 7 TYR A 950
VAL A1122
GLY A1123
THR A1163
 None
 0.90A 2a1mA-3i36A:
undetectable		 2a1mA-3i36A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_2
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 6 PHE A1169
GLN A 913
ASN A 917
ASN A 904
 None
 0.89A 2nyrA-3i36A:
undetectable		 2nyrA-3i36A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 PHE A 920
PHE A 909
PHE A 905
 None
 0.87A 2od9A-3i36A:
undetectable		 2od9A-3i36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 PHE A 920
PHE A 909
PHE A 905
 None
 0.87A 2qqgA-3i36A:
undetectable		 2qqgA-3i36A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_GLYA333_0
(CHOLOYLGLYCINE
HYDROLASE)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 ASN A 948
ASN A 975
ARG A1157
 None
 0.72A 2rlcA-3i36A:
undetectable		 2rlcA-3i36A:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 ARG A 960
ASP A1001
ASN A 944
 None
 0.81A 2zzmA-3i36A:
undetectable		 2zzmA-3i36A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 11 ILE A 989
ILE A1014
ILE A 974
VAL A1011
PRO A1113
 None
 0.93A 3tmzA-3i36A:
undetectable		 3tmzA-3i36A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KM2_A_TOPA202_1
(DIHYDROFOLATE
REDUCTASE)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 ILE A1135
ILE A1114
LEU A1017
LEU A1094
ILE A1131
 None
 0.75A 4km2A-3i36A:
undetectable		 4km2A-3i36A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 ILE A1135
ILE A1114
LEU A1017
LEU A1094
ILE A1131
 None
 0.93A 4m2xA-3i36A:
undetectable		 4m2xA-3i36A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 ILE A1135
ILE A1114
LEU A1017
LEU A1094
ILE A1131
 None
 1.06A 4m2xE-3i36A:
undetectable		 4m2xE-3i36A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 VAL A1116
ALA A 990
PHE A1097
PHE A1128
GLY A1126
 None
 1.18A 4mm6A-3i36A:
undetectable		 4mm6A-3i36A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 GLY A1121
ILE A 989
ASN A 977
SER A1119
PHE A1002
 None
 1.21A 4obwC-3i36A:
undetectable		 4obwC-3i36A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_B_377B401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 5 GLU A 922
GLU A 923
TYR A 908
PHE A 920
 None
 1.27A 4twdA-3i36A:
0.0
4twdB-3i36A:
0.0		 4twdA-3i36A:
21.68
4twdB-3i36A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ4_B_ACTB403_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		3 / 3 ARG A1059
ASP A1060
ARG A1075
 None
 0.44A 4wq4B-3i36A:
undetectable		 4wq4B-3i36A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		5 / 12 GLY A1126
GLY A1123
THR A1127
GLN A1166
LEU A1153
 None
 1.11A 5kocB-3i36A:
undetectable		 5kocB-3i36A:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3i36 VASCULAR PROTEIN
TYROSINE PHOSPHATASE
1
(Rattus
norvegicus) 		4 / 8 LEU A1115
VAL A1011
VAL A1045
VAL A1063
 None
 1.09A 6cp4A-3i36A:
undetectable		 6cp4A-3i36A:
21.11