SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i3l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EA1_A_TPFA470_1
(CYTOCHROME P450
51-LIKE RV0764C)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 PHE A 562
ARG A 439
PHE A  89
THR A 205
None
1.27A 1ea1A-3i3lA:
undetectable
1ea1A-3i3lA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 7 PHE A 304
LEU A  47
ALA A 102
PHE A  89
VAL A 103
None
1.47A 1epbA-3i3lA:
undetectable
1epbA-3i3lA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_2
(HMG-COA REDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 SER A 312
VAL A  17
SER A  16
ASP A 111
None
1.10A 1hwiB-3i3lA:
3.2
1hwiB-3i3lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 SER A 312
VAL A  17
SER A  16
ASP A 111
None
1.08A 1hwkA-3i3lA:
3.0
1hwkA-3i3lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_C_117C4_1
(HMG-COA REDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 SER A 312
VAL A  17
SER A  16
ASP A 111
None
1.05A 1hwkC-3i3lA:
3.2
1hwkC-3i3lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_D_117D3_2
(HMG-COA REDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 SER A 312
VAL A  17
SER A  16
ASP A 111
None
1.03A 1hwkD-3i3lA:
3.3
1hwkD-3i3lA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_0
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 THR A 154
VAL A 153
SER A 152
GLY A 168
THR A 132
None
None
None
FAD  A 600 ( 4.7A)
None
1.10A 1jg4A-3i3lA:
2.7
1jg4A-3i3lA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_2
(LIVER
CARBOXYLESTERASE I)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
3 / 3 PHE A 430
LEU A 435
MET A 415
None
0.88A 1mx1D-3i3lA:
undetectable
1mx1D-3i3lA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 11 SER A  16
SER A 312
LEU A  46
VAL A 105
VAL A 308
None
None
None
None
FAD  A 600 (-3.6A)
1.14A 1q23J-3i3lA:
undetectable
1q23J-3i3lA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X1A_A_SAMA4264_0
(CRTF-RELATED PROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 ALA A  18
GLY A 164
GLY A  10
ILE A 161
CYH A 293
None
FAD  A 600 (-3.4A)
FAD  A 600 (-3.4A)
None
None
0.94A 1x1aA-3i3lA:
2.4
1x1aA-3i3lA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZEA_A_DHIA6_0
(MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
H CHAIN
MONOCLONAL
ANTI-CHOLERA TOXIN
IGG1 KAPPA ANTIBODY,
L CHAIN
SHORT SYNTHETIC
D-AMINO ACID PEPTIDE
D2)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
3 / 3 TRP A 215
ARG A 374
PHE A 370
None
1.33A 1zeaH-3i3lA:
undetectable
1zeaL-3i3lA:
undetectable
1zeaH-3i3lA:
15.70
1zeaL-3i3lA:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 GLY A  19
ALA A  18
GLY A  12
GLY A  11
ILE A 161
None
None
FAD  A 600 (-3.6A)
None
None
0.83A 2avsA-3i3lA:
undetectable
2avsA-3i3lA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 GLY A  19
ALA A  18
GLY A  12
GLY A  11
ILE A 161
None
None
FAD  A 600 (-3.6A)
None
None
0.76A 2avvA-3i3lA:
undetectable
2avvA-3i3lA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_1
(POL PROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 GLY A  19
ALA A  18
GLY A  12
GLY A  11
ILE A 161
None
None
FAD  A 600 (-3.6A)
None
None
0.79A 2fxeA-3i3lA:
undetectable
2fxeA-3i3lA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 PHE A  99
LEU A  54
ASN A  55
VAL A 308
VAL A 103
None
None
None
FAD  A 600 (-3.6A)
None
1.16A 2vn0A-3i3lA:
undetectable
2vn0A-3i3lA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1351_1
(PROSTAGLANDIN
REDUCTASE 2)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 10 PHE A 456
TYR A 495
LEU A 522
VAL A 519
LEU A 518
None
1.31A 2w98A-3i3lA:
3.2
2w98A-3i3lA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA802_1
(PROSTAGLANDIN
REDUCTASE 1)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 7 TYR A 358
ARG A 375
GLY A  79
ASP A  81
None
0.71A 2y05A-3i3lA:
3.6
2y05B-3i3lA:
3.7
2y05A-3i3lA:
19.97
2y05B-3i3lA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
6 / 12 GLY A  19
ILE A 322
LEU A  20
ALA A 118
ARG A 119
VAL A   6
None
1.26A 2yqzA-3i3lA:
3.1
2yqzA-3i3lA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS8_A_BRLA503_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 GLY A  12
SER A 312
ILE A  53
LEU A  57
LEU A  46
FAD  A 600 (-3.6A)
None
None
None
None
1.02A 3cs8A-3i3lA:
undetectable
3cs8A-3i3lA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 GLY A  19
ALA A  18
GLY A  12
GLY A  11
ILE A 161
None
None
FAD  A 600 (-3.6A)
None
None
0.81A 3cyxB-3i3lA:
undetectable
3cyxB-3i3lA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D41_A_FCNA4001_1
(FOMA PROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 GLY A 563
GLY A 564
GLY A  49
ILE A  53
None
0.44A 3d41A-3i3lA:
undetectable
3d41A-3i3lA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW3_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 10 GLU A  33
LEU A 115
ILE A 123
LEU A  20
ILE A   8
FAD  A 600 (-2.8A)
None
None
None
None
1.08A 3jw3A-3i3lA:
undetectable
3jw3A-3i3lA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_A_017A200_2
(FIV PROTEASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 10 ILE A 170
VAL A 134
GLY A  10
ILE A  31
VAL A 155
None
None
FAD  A 600 (-3.4A)
None
None
1.32A 3ogpB-3i3lA:
undetectable
3ogpB-3i3lA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 7 VAL A 160
ILE A   9
THR A 145
THR A 154
None
FAD  A 600 ( 4.9A)
None
None
1.05A 3tneB-3i3lA:
undetectable
3tneB-3i3lA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LAJ_B_ACAB512_1
(HIV-1 YU2 GP120
ENVELOPE
GLYCOPROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 6 ARG A 184
ASP A 180
HIS A 351
ARG A 374
None
1.17A 4lajA-3i3lA:
undetectable
4lajB-3i3lA:
undetectable
4lajA-3i3lA:
20.17
4lajB-3i3lA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWZ_B_CQAB303_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 GLY A  15
GLY A 164
ILE A   9
LEU A 292
None
FAD  A 600 (-3.4A)
FAD  A 600 ( 4.9A)
None
0.79A 4mwzB-3i3lA:
undetectable
4mwzB-3i3lA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 4 THR A  86
GLY A 204
ASP A 196
SER A  73
None
1.40A 4rfqA-3i3lA:
3.2
4rfqA-3i3lA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 7 ILE A  31
LEU A 115
GLY A  12
GLY A  11
None
None
FAD  A 600 (-3.6A)
None
0.76A 5a06A-3i3lA:
undetectable
5a06A-3i3lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 7 ILE A  31
LEU A 115
GLY A  12
GLY A  11
None
None
FAD  A 600 (-3.6A)
None
0.78A 5a06C-3i3lA:
undetectable
5a06C-3i3lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 7 ILE A  31
LEU A 115
GLY A  12
GLY A  11
None
None
FAD  A 600 (-3.6A)
None
0.76A 5a06E-3i3lA:
2.6
5a06E-3i3lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 7 ILE A  31
LEU A 115
GLY A  12
GLY A  11
None
None
FAD  A 600 (-3.6A)
None
0.78A 5a06F-3i3lA:
undetectable
5a06F-3i3lA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IMS_A_ACTA708_0
(ACETOLACTATE
SYNTHASE CATALYTIC
SUBUNIT,
MITOCHONDRIAL)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
3 / 3 GLY A 563
GLY A 564
GLN A 313
None
0.47A 5imsA-3i3lA:
undetectable
5imsA-3i3lA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 ILE A  31
ASP A 111
LEU A  22
VAL A   6
ALA A 297
None
1.08A 5uxdB-3i3lA:
undetectable
5uxdB-3i3lA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_B_C2FB702_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 5 ASP A 301
ASN A 185
ASP A 233
ARG A 383
None
1.39A 5vooB-3i3lA:
undetectable
5vooB-3i3lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_D_C2FD3001_1
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 5 ASP A 301
ASN A 185
ASP A 233
ARG A 383
None
1.38A 5vooD-3i3lA:
undetectable
5vooD-3i3lA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 LEU A  46
VAL A 103
VAL A 105
ILE A  63
None
0.74A 5y9mA-3i3lA:
undetectable
5y9mA-3i3lA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_0
(STIE PROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 GLY A 165
GLY A 167
ILE A   9
PHE A 299
LEU A 292
FAD  A 600 (-3.6A)
None
FAD  A 600 ( 4.9A)
None
None
0.97A 6ectA-3i3lA:
2.5
6ectA-3i3lA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_0
(STIE PROTEIN)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
5 / 12 GLY A 165
GLY A 167
ILE A   9
PHE A 299
LEU A 292
FAD  A 600 (-3.6A)
None
FAD  A 600 ( 4.9A)
None
None
0.93A 6ecxA-3i3lA:
2.4
6ecxA-3i3lA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 5 THR A  21
THR A  50
HIS A 309
GLY A  15
None
1.21A 6gbnC-3i3lA:
4.1
6gbnC-3i3lA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 ASP A 100
HIS A 101
GLU A 432
ASP A 201
None
1.20A 6mn4D-3i3lA:
undetectable
6mn4D-3i3lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_D_AM2D301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
4 / 8 ASP A 180
ARG A 374
ASP A 233
GLU A 369
None
1.19A 6mn4D-3i3lA:
undetectable
6mn4D-3i3lA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)
3i3l ALKYLHALIDASE CMLS
(Streptomyces
venezuelae)
3 / 3 ASP A 116
LEU A 115
ARG A  39
None
None
FAD  A 600 (-3.8A)
0.79A 7dfrA-3i3lA:
undetectable
7dfrA-3i3lA:
16.37