SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i3t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V54_C_CHDC3271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE III CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 8	LYS A 379 LEU A 378 GLN A 453 PHE A 397	None	0.84A	1v54C-3i3tA: undetectable 1v54J-3i3tA: undetectable	1v54C-3i3tA: 21.07 1v54J-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1V54_P_CHDP4271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE III CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 8	LYS A 379 LEU A 378 GLN A 453 PHE A 397	None	0.84A	1v54P-3i3tA: undetectable 1v54W-3i3tA: undetectable	1v54P-3i3tA: 21.07 1v54W-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYR_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 8	LYS A 379 LEU A 378 GLN A 453 PHE A 397	None	0.84A	2dyrC-3i3tA: undetectable 2dyrJ-3i3tA: undetectable	2dyrC-3i3tA: 21.07 2dyrJ-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DYR_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 8	LYS A 379 LEU A 378 GLN A 453 PHE A 397	None	0.83A	2dyrP-3i3tA: undetectable 2dyrW-3i3tA: undetectable	2dyrP-3i3tA: 21.07 2dyrW-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIK_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 8	LYS A 379 LEU A 378 GLN A 453 PHE A 397	None	0.83A	2eikP-3i3tA: undetectable 2eikW-3i3tA: undetectable	2eikP-3i3tA: 21.07 2eikW-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EIL_C_CHDC271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 8	LYS A 379 LEU A 378 GLN A 453 PHE A 397	None	0.83A	2eilC-3i3tA: undetectable 2eilJ-3i3tA: undetectable	2eilC-3i3tA: 21.07 2eilJ-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ITZ_A_IREA2021_2 (EPIDERMAL GROWTH FACTOR RECEPTOR)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	3 / 3	LEU A 553 LEU A 557 MET A 558	None	0.80A	2itzA-3i3tA: undetectable	2itzA-3i3tA: 20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OUZ_A_C3DA999_0 (ESTROGEN RECEPTOR)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	5 / 12	LEU A 507 LEU A 459 LEU A 416 LEU A 484 LEU A 463	None	0.95A	2ouzA-3i3tA: undetectable	2ouzA-3i3tA: 22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG2_C_CHDC271_0 (CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.98A	3ag2C-3i3tA: undetectable	3ag2C-3i3tA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AG2_P_CHDP1271_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	1.00A	3ag2P-3i3tA: undetectable 3ag2W-3i3tA: undetectable	3ag2P-3i3tA: 21.07 3ag2W-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_F_SAMF300_0 (PUTATIVE RRNA METHYLASE)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	5 / 12	GLY A 213 ASN A 224 HIS A 530 LEU A 269 THR A 527	None	1.13A	3eeyF-3i3tA: undetectable	3eeyF-3i3tA: 19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSF_B_PZIB802_0 (GLUTAMATE RECEPTOR 2)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	3 / 3	SER A 494 ASP A 352 ASN A 356	None	0.77A	3lsfB-3i3tA: undetectable 3lsfE-3i3tA: undetectable	3lsfB-3i3tA: 21.01 3lsfE-3i3tA: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LSF_E_PZIE802_0 (GLUTAMATE RECEPTOR 2)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	3 / 3	ASP A 352 ASN A 356 SER A 494	None	0.81A	3lsfB-3i3tA: undetectable 3lsfE-3i3tA: undetectable	3lsfB-3i3tA: 21.01 3lsfE-3i3tA: 21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3X2Q_C_CHDC304_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.92A	3x2qC-3i3tA: undetectable 3x2qJ-3i3tA: undetectable	3x2qC-3i3tA: 21.07 3x2qJ-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3X2Q_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.90A	3x2qP-3i3tA: undetectable 3x2qW-3i3tA: undetectable	3x2qP-3i3tA: 21.07 3x2qW-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ECK_A_FOLA703_0 (BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLAT E SYNTHASE)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	5 / 12	LEU A 461 PHE A 420 PHE A 423 PHE A 455 LEU A 378	None	1.03A	4eckA-3i3tA: undetectable	4eckA-3i3tA: 19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B1A_C_CHDC304_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.95A	5b1aC-3i3tA: undetectable 5b1aJ-3i3tA: undetectable	5b1aC-3i3tA: 21.07 5b1aJ-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B1A_P_CHDP305_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.87A	5b1aP-3i3tA: undetectable 5b1aW-3i3tA: undetectable	5b1aP-3i3tA: 21.07 5b1aW-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B1B_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.96A	5b1bP-3i3tA: undetectable 5b1bW-3i3tA: undetectable	5b1bP-3i3tA: 21.07 5b1bW-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B3S_C_CHDC307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.90A	5b3sC-3i3tA: undetectable 5b3sJ-3i3tA: undetectable	5b3sC-3i3tA: 21.07 5b3sJ-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B3S_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.90A	5b3sP-3i3tA: undetectable	5b3sP-3i3tA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B3S_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LYS A 379 LEU A 378 GLN A 453 PHE A 397	None	0.94A	5b3sP-3i3tA: undetectable	5b3sP-3i3tA: 21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HRQ_K_IPHK101_0 (INSULIN A-CHAIN INSULIN B-CHAIN)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	VAL A 537 HIS A 530 CYH A 523 HIS A 211	None	0.98A	5hrqH-3i3tA: undetectable 5hrqK-3i3tA: undetectable 5hrqL-3i3tA: undetectable	5hrqH-3i3tA: 6.43 5hrqK-3i3tA: 5.00 5hrqL-3i3tA: 6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEP_A_VDYA201_1 (CDL2.3B)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	5 / 12	PHE A 287 LEU A 306 PHE A 283 PHE A 262 LEU A 236	None	1.21A	5iepA-3i3tA: undetectable	5iepA-3i3tA: 16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IY5_C_CHDC307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.87A	5iy5C-3i3tA: undetectable 5iy5J-3i3tA: undetectable	5iy5C-3i3tA: 20.87 5iy5J-3i3tA: 9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JGL_B_SAMB301_1 (UBIE/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	3 / 3	ASP A 399 ASN A 464 PHE A 305	None	0.87A	5jglB-3i3tA: undetectable	5jglB-3i3tA: 19.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5XU8_A_DX4A701_0 (UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	5 / 8	GLY A 213 LEU A 214 ASN A 224 GLN A 228 ALA A 521	None	0.27A	5xu8A-3i3tA: 40.8	5xu8A-3i3tA: 49.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z84_C_CHDC307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	5 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.13A	5z84C-3i3tA: undetectable 5z84J-3i3tA: undetectable	5z84C-3i3tA: 21.07 5z84J-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z84_P_CHDP305_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.06A	5z84P-3i3tA: undetectable 5z84W-3i3tA: undetectable	5z84P-3i3tA: 21.07 5z84W-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z85_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.95A	5z85C-3i3tA: undetectable 5z85J-3i3tA: undetectable	5z85C-3i3tA: 21.07 5z85J-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z85_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.12A	5z85P-3i3tA: undetectable 5z85W-3i3tA: undetectable	5z85P-3i3tA: 21.07 5z85W-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z86_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.05A	5z86C-3i3tA: undetectable 5z86J-3i3tA: undetectable	5z86C-3i3tA: 21.07 5z86J-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z86_P_CHDP307_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.02A	5z86P-3i3tA: undetectable 5z86W-3i3tA: undetectable	5z86P-3i3tA: 21.07 5z86W-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCO_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.93A	5zcoC-3i3tA: undetectable 5zcoJ-3i3tA: undetectable	5zcoC-3i3tA: 21.07 5zcoJ-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCO_P_CHDP305_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.09A	5zcoP-3i3tA: undetectable 5zcoW-3i3tA: undetectable	5zcoP-3i3tA: 21.07 5zcoW-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCP_C_CHDC306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.05A	5zcpC-3i3tA: undetectable 5zcpJ-3i3tA: undetectable	5zcpC-3i3tA: 21.07 5zcpJ-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCP_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 6	GLN A 453 PHE A 397 LEU A 400 PHE A 420	None	1.07A	5zcpP-3i3tA: undetectable 5zcpW-3i3tA: undetectable	5zcpP-3i3tA: 21.07 5zcpW-3i3tA: 9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ZCQ_P_CHDP306_0 (CYTOCHROME C OXIDASE SUBUNIT 3 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	3i3t	UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21 (Homo sapiens)	4 / 7	LEU A 378 GLN A 453 PHE A 397 LEU A 400	None	0.93A	5zcqP-3i3tA: undetectable 5zcqW-3i3tA: undetectable	5zcqP-3i3tA: 21.07 5zcqW-3i3tA: 9.68

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1V54_C_CHDC3271_0","CYTOCHROME C OXIDASE POLYPEPTIDE III;CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LYS A 379;LEU A 378;GLN A 453;PHE A 397","None","0.84A","1v54C-3i3tA:undetectable;1v54J-3i3tA:undetectable","1v54C-3i3tA:21.07;1v54J-3i3tA:9.68"],["1V54_P_CHDP4271_0","CYTOCHROME C OXIDASE POLYPEPTIDE III;CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LYS A 379;LEU A 378;GLN A 453;PHE A 397","None","0.84A","1v54P-3i3tA:undetectable;1v54W-3i3tA:undetectable","1v54P-3i3tA:21.07;1v54W-3i3tA:9.68"],["2DYR_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LYS A 379;LEU A 378;GLN A 453;PHE A 397","None","0.84A","2dyrC-3i3tA:undetectable;2dyrJ-3i3tA:undetectable","2dyrC-3i3tA:21.07;2dyrJ-3i3tA:9.68"],["2DYR_P_CHDP1271_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LYS A 379;LEU A 378;GLN A 453;PHE A 397","None","0.83A","2dyrP-3i3tA:undetectable;2dyrW-3i3tA:undetectable","2dyrP-3i3tA:21.07;2dyrW-3i3tA:9.68"],["2EIK_P_CHDP1271_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LYS A 379;LEU A 378;GLN A 453;PHE A 397","None","0.83A","2eikP-3i3tA:undetectable;2eikW-3i3tA:undetectable","2eikP-3i3tA:21.07;2eikW-3i3tA:9.68"],["2EIL_C_CHDC271_0","CYTOCHROME C OXIDASE POLYPEPTIDE VIIA-HEART;CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LYS A 379;LEU A 378;GLN A 453;PHE A 397","None","0.83A","2eilC-3i3tA:undetectable;2eilJ-3i3tA:undetectable","2eilC-3i3tA:21.07;2eilJ-3i3tA:9.68"],["2ITZ_A_IREA2021_2","EPIDERMAL GROWTH FACTOR RECEPTOR","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",3,"LEU A 553;LEU A 557;MET A 558","None","0.80A","2itzA-3i3tA:undetectable","2itzA-3i3tA:20.86"],["2OUZ_A_C3DA999_0","ESTROGEN RECEPTOR","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",5,"LEU A 507;LEU A 459;LEU A 416;LEU A 484;LEU A 463","None","0.95A","2ouzA-3i3tA:undetectable","2ouzA-3i3tA:22.22"],["3AG2_C_CHDC271_0","CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.98A","3ag2C-3i3tA:undetectable","3ag2C-3i3tA:21.07"],["3AG2_P_CHDP1271_0","CYTOCHROME C OXIDASE POLYPEPTIDE 7A1;CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","1.00A","3ag2P-3i3tA:undetectable;3ag2W-3i3tA:undetectable","3ag2P-3i3tA:21.07;3ag2W-3i3tA:9.68"],["3EEY_F_SAMF300_0","PUTATIVE RRNA METHYLASE","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",5,"GLY A 213;ASN A 224;HIS A 530;LEU A 269;THR A 527","None","1.13A","3eeyF-3i3tA:undetectable","3eeyF-3i3tA:19.38"],["3LSF_B_PZIB802_0","GLUTAMATE RECEPTOR 2","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",3,"SER A 494;ASP A 352;ASN A 356","None","0.77A","3lsfB-3i3tA:undetectable;3lsfE-3i3tA:undetectable","3lsfB-3i3tA:21.01;3lsfE-3i3tA:21.01"],["3LSF_E_PZIE802_0","GLUTAMATE RECEPTOR 2","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",3,"ASP A 352;ASN A 356;SER A 494","None","0.81A","3lsfB-3i3tA:undetectable;3lsfE-3i3tA:undetectable","3lsfB-3i3tA:21.01;3lsfE-3i3tA:21.01"],["3X2Q_C_CHDC304_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.92A","3x2qC-3i3tA:undetectable;3x2qJ-3i3tA:undetectable","3x2qC-3i3tA:21.07;3x2qJ-3i3tA:9.68"],["3X2Q_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.90A","3x2qP-3i3tA:undetectable;3x2qW-3i3tA:undetectable","3x2qP-3i3tA:21.07;3x2qW-3i3tA:9.68"],["4ECK_A_FOLA703_0","BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",5,"LEU A 461;PHE A 420;PHE A 423;PHE A 455;LEU A 378","None","1.03A","4eckA-3i3tA:undetectable","4eckA-3i3tA:19.09"],["5B1A_C_CHDC304_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.95A","5b1aC-3i3tA:undetectable;5b1aJ-3i3tA:undetectable","5b1aC-3i3tA:21.07;5b1aJ-3i3tA:9.68"],["5B1A_P_CHDP305_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.87A","5b1aP-3i3tA:undetectable;5b1aW-3i3tA:undetectable","5b1aP-3i3tA:21.07;5b1aW-3i3tA:9.68"],["5B1B_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.96A","5b1bP-3i3tA:undetectable;5b1bW-3i3tA:undetectable","5b1bP-3i3tA:21.07;5b1bW-3i3tA:9.68"],["5B3S_C_CHDC307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.90A","5b3sC-3i3tA:undetectable;5b3sJ-3i3tA:undetectable","5b3sC-3i3tA:21.07;5b3sJ-3i3tA:9.68"],["5B3S_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.90A","5b3sP-3i3tA:undetectable","5b3sP-3i3tA:21.07"],["5B3S_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LYS A 379;LEU A 378;GLN A 453;PHE A 397","None","0.94A","5b3sP-3i3tA:undetectable","5b3sP-3i3tA:21.07"],["5HRQ_K_IPHK101_0","INSULIN A-CHAIN;INSULIN B-CHAIN","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"VAL A 537;HIS A 530;CYH A 523;HIS A 211","None","0.98A","5hrqH-3i3tA:undetectable;5hrqK-3i3tA:undetectable;5hrqL-3i3tA:undetectable","5hrqH-3i3tA:6.43;5hrqK-3i3tA:5.00;5hrqL-3i3tA:6.43"],["5IEP_A_VDYA201_1","CDL2.3B","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",5,"PHE A 287;LEU A 306;PHE A 283;PHE A 262;LEU A 236","None","1.21A","5iepA-3i3tA:undetectable","5iepA-3i3tA:16.34"],["5IY5_C_CHDC307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.87A","5iy5C-3i3tA:undetectable;5iy5J-3i3tA:undetectable","5iy5C-3i3tA:20.87;5iy5J-3i3tA:9.83"],["5JGL_B_SAMB301_1","UBIE\/COQ5 FAMILY METHYLTRANSFERASE, PUTATIVE","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",3,"ASP A 399;ASN A 464;PHE A 305","None","0.87A","5jglB-3i3tA:undetectable","5jglB-3i3tA:19.89"],["5XU8_A_DX4A701_0","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 2","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",5,"GLY A 213;LEU A 214;ASN A 224;GLN A 228;ALA A 521","None","0.27A","5xu8A-3i3tA:40.8","5xu8A-3i3tA:49.72"],["5Z84_C_CHDC307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",5,"LEU A 378;GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.13A","5z84C-3i3tA:undetectable;5z84J-3i3tA:undetectable","5z84C-3i3tA:21.07;5z84J-3i3tA:9.68"],["5Z84_P_CHDP305_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.06A","5z84P-3i3tA:undetectable;5z84W-3i3tA:undetectable","5z84P-3i3tA:21.07;5z84W-3i3tA:9.68"],["5Z85_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.95A","5z85C-3i3tA:undetectable;5z85J-3i3tA:undetectable","5z85C-3i3tA:21.07;5z85J-3i3tA:9.68"],["5Z85_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.12A","5z85P-3i3tA:undetectable;5z85W-3i3tA:undetectable","5z85P-3i3tA:21.07;5z85W-3i3tA:9.68"],["5Z86_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.05A","5z86C-3i3tA:undetectable;5z86J-3i3tA:undetectable","5z86C-3i3tA:21.07;5z86J-3i3tA:9.68"],["5Z86_P_CHDP307_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.02A","5z86P-3i3tA:undetectable;5z86W-3i3tA:undetectable","5z86P-3i3tA:21.07;5z86W-3i3tA:9.68"],["5ZCO_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.93A","5zcoC-3i3tA:undetectable;5zcoJ-3i3tA:undetectable","5zcoC-3i3tA:21.07;5zcoJ-3i3tA:9.68"],["5ZCO_P_CHDP305_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.09A","5zcoP-3i3tA:undetectable;5zcoW-3i3tA:undetectable","5zcoP-3i3tA:21.07;5zcoW-3i3tA:9.68"],["5ZCP_C_CHDC306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.05A","5zcpC-3i3tA:undetectable;5zcpJ-3i3tA:undetectable","5zcpC-3i3tA:21.07;5zcpJ-3i3tA:9.68"],["5ZCP_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"GLN A 453;PHE A 397;LEU A 400;PHE A 420","None","1.07A","5zcpP-3i3tA:undetectable;5zcpW-3i3tA:undetectable","5zcpP-3i3tA:21.07;5zcpW-3i3tA:9.68"],["5ZCQ_P_CHDP306_0","CYTOCHROME C OXIDASE SUBUNIT 3;CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL","3i3t","UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 21","Homo sapiens",4,"LEU A 378;GLN A 453;PHE A 397;LEU A 400","None","0.93A","5zcqP-3i3tA:undetectable;5zcqW-3i3tA:undetectable","5zcqP-3i3tA:21.07;5zcqW-3i3tA:9.68"]]