SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i3v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 10 VAL A  62
VAL A  44
VAL A  99
ILE A 332
LEU A 339
 None
 1.24A 1fe2A-3i3vA:
undetectable		 1fe2A-3i3vA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 8 PHE A 322
LEU A  59
PHE A 338
MET A 342
 None
 0.96A 1wrlC-3i3vA:
undetectable
1wrlD-3i3vA:
undetectable		 1wrlC-3i3vA:
13.86
1wrlD-3i3vA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 7 PHE A 322
LEU A  59
PHE A 338
MET A 342
 None
 0.99A 1wrlE-3i3vA:
undetectable		 1wrlE-3i3vA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_F_TFPF211_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 7 PHE A 322
LEU A  59
PHE A 338
MET A 342
 None
 0.99A 1wrlE-3i3vA:
undetectable
1wrlF-3i3vA:
undetectable		 1wrlE-3i3vA:
13.86
1wrlF-3i3vA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 8 LEU A 209
PHE A 409
VAL A 252
ALA A 257
 None
 0.98A 3ax9A-3i3vA:
undetectable		 3ax9A-3i3vA:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 9 GLN A 220
VAL A 386
HIS A 308
ILE A 214
VAL A 226
 None
 1.45A 3fi0M-3i3vA:
undetectable		 3fi0M-3i3vA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 7 GLY A 321
PHE A 322
PHE A 341
PHE A 338
 None
 1.11A 3ko0D-3i3vA:
undetectable
3ko0E-3i3vA:
undetectable		 3ko0D-3i3vA:
12.59
3ko0E-3i3vA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PP7_B_SVRB499_1
(PYRUVATE KINASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 10 THR A 295
PRO A 288
ASN A 163
GLY A 293
ALA A 292
 None
 1.48A 3pp7B-3i3vA:
undetectable		 3pp7B-3i3vA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 11 ALA A 211
GLN A 215
ILE A 214
PHE A 217
THR A 156
 None
 1.20A 3qelA-3i3vA:
undetectable
3qelB-3i3vA:
2.0		 3qelA-3i3vA:
19.62
3qelB-3i3vA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_D_QELD2_2
(GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 9 ALA A 211
GLN A 215
ILE A 214
PHE A 217
THR A 156
 None
 1.23A 3qelD-3i3vA:
undetectable		 3qelD-3i3vA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 10 ARG A 378
ALA A 375
LEU A 379
GLY A 380
ALA A 185
 None
 1.45A 4fe1A-3i3vA:
undetectable
4fe1J-3i3vA:
undetectable		 4fe1A-3i3vA:
20.23
4fe1J-3i3vA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 8 VAL A 393
TYR A 227
GLY A 230
ALA A 398
 None
 0.91A 4m48A-3i3vA:
undetectable		 4m48A-3i3vA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		3 / 3 ARG A 411
ASP A 255
ARG A 187
 None
 0.84A 4mx0A-3i3vA:
undetectable		 4mx0A-3i3vA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 8 THR A 353
GLY A 374
VAL A 373
ASP A 358
 None
 0.80A 4qvvK-3i3vA:
undetectable
4qvvL-3i3vA:
undetectable		 4qvvK-3i3vA:
20.66
4qvvL-3i3vA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 8 THR A 353
GLY A 374
VAL A 373
ASP A 358
 None
 0.80A 4qvvY-3i3vA:
undetectable
4qvvZ-3i3vA:
undetectable		 4qvvY-3i3vA:
20.66
4qvvZ-3i3vA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 6 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.14A 4w5qA-3i3vA:
undetectable		 4w5qA-3i3vA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 6 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.18A 4w5tA-3i3vA:
undetectable		 4w5tA-3i3vA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 6 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.16A 4z4cA-3i3vA:
undetectable		 4z4cA-3i3vA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 6 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.15A 4z4fA-3i3vA:
2.1		 4z4fA-3i3vA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 5 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.15A 4z4gA-3i3vA:
undetectable		 4z4gA-3i3vA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 6 ASP A 119
ALA A 150
THR A 112
THR A 117
 None
 1.13A 4z4iA-3i3vA:
undetectable		 4z4iA-3i3vA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 7 PHE A 154
ILE A 320
PHE A 351
GLY A  54
 None
 0.74A 4zdzA-3i3vA:
undetectable		 4zdzA-3i3vA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 8 PHE A 154
ILE A 320
PHE A 351
GLY A  54
 None
 0.73A 5esfA-3i3vA:
undetectable		 5esfA-3i3vA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 8 PHE A 154
ILE A 320
PHE A 351
GLY A  54
 None
 0.75A 5esjA-3i3vA:
0.7		 5esjA-3i3vA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 12 ALA A 211
GLN A 215
ILE A 214
PHE A 217
THR A 156
 None
 1.15A 5ewjC-3i3vA:
2.6
5ewjD-3i3vA:
undetectable		 5ewjC-3i3vA:
19.34
5ewjD-3i3vA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 12 PHE A 154
ILE A 320
PHE A 351
GLY A  54
LEU A  59
 None
 1.15A 5fsaA-3i3vA:
undetectable		 5fsaA-3i3vA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 9 LEU A 319
ASN A 103
GLY A  80
PRO A  53
ILE A 320
 None
 1.06A 5kqxB-3i3vA:
undetectable		 5kqxB-3i3vA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 12 PHE A 154
ILE A 320
PHE A 338
GLY A  54
LEU A  59
 None
 1.28A 5v5zA-3i3vA:
undetectable		 5v5zA-3i3vA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 12 PHE A 154
ILE A 320
PHE A 351
GLY A  54
LEU A  59
 None
 1.05A 5v5zA-3i3vA:
undetectable		 5v5zA-3i3vA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA502_1
(CYTOCHROME P450 2C9)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		5 / 12 ALA A 275
LEU A 167
GLY A 298
THR A 312
LEU A 209
 None
 1.21A 5x24A-3i3vA:
undetectable		 5x24A-3i3vA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BZO_C_FI8C1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
RNA POLYMERASE SIGMA
FACTOR SIGA)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 4 LEU A  83
ASP A  82
GLN A  85
VAL A 148
 None
 1.33A 6bzoF-3i3vA:
undetectable		 6bzoF-3i3vA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN
(Streptomyces
coelicolor) 		4 / 6 PRO A 311
ILE A 175
GLY A 298
GLU A 296
 None
 1.04A 6gqiA-3i3vA:
undetectable		 6gqiA-3i3vA:
24.82