SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i3w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_0
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 4 THR A  24
LEU A  27
LEU A  34
GLN A  37
 None
 1.25A 1fbmA-3i3wA:
undetectable		 1fbmA-3i3wA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JB0_B_PQNB2002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 11 PHE A 188
SER A 204
ILE A 223
LEU A 238
ALA A 184
 None
 1.48A 1jb0B-3i3wA:
undetectable		 1jb0B-3i3wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JU6_D_LYAD315_1
(THYMIDYLATE SYNTHASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 11 PHE A  96
ILE A 110
LEU A  57
GLY A  54
ALA A  15
 None
 1.49A 1ju6D-3i3wA:
undetectable		 1ju6D-3i3wA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ILE A 236
GLY A 235
GLY A 252
VAL A 175
LEU A 192
 None
 0.96A 1vptA-3i3wA:
undetectable		 1vptA-3i3wA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I2Z_A_SALA1100_1
(SERUM ALBUMIN)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 5 LEU A 264
ILE A 263
ILE A 348
ALA A 347
 None
 0.76A 2i2zA-3i3wA:
undetectable		 2i2zA-3i3wA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 8 SER A 237
GLY A 216
SER A 204
ALA A 203
 None
 0.89A 2vh3B-3i3wA:
undetectable		 2vh3B-3i3wA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_A_SALA1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 9 THR A 341
ILE A 245
GLY A 338
GLY A 336
ARG A 244
 None
None
None
None
SEP  A 101 ( 4.1A)
 1.42A 2y7wA-3i3wA:
2.0		 2y7wA-3i3wA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 GLU A 322
GLY A 321
TYR A 307
ILE A 319
GLN A 344
 None
 1.48A 3bwyA-3i3wA:
undetectable		 3bwyA-3i3wA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC201_1
(PROTEIN S100-A4)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 9 PHE A 340
GLY A 321
ILE A 263
PHE A 168
PHE A 165
 None
 1.49A 3ko0A-3i3wA:
undetectable
3ko0C-3i3wA:
undetectable		 3ko0A-3i3wA:
14.29
3ko0C-3i3wA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZW_A_KKKA413_1
(FLAVOHEMOGLOBIN)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 8 ILE A  98
ALA A  60
LEU A  61
LEU A 112
 None
 0.85A 3ozwA-3i3wA:
undetectable		 3ozwA-3i3wA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PCQ_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 11 PHE A 188
SER A 204
ILE A 223
LEU A 238
ALA A 184
 None
 1.48A 3pcqB-3i3wA:
undetectable		 3pcqB-3i3wA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGL_A_RZXA257_1
(CARBOXY-TERMINAL
DOMAIN RNA
POLYMERASE II
POLYPEPTIDE A SMALL
PHOSPHATASE 1)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 7 PHE A 188
VAL A 177
ILE A 236
TYR A 199
 None
 1.00A 3pglA-3i3wA:
undetectable		 3pglA-3i3wA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		6 / 12 GLY A 338
ASP A 239
ILE A 202
ALA A 184
ALA A 180
ALA A 203
 None
ZN  A 900 (-2.3A)
None
None
None
None
 1.29A 3sudC-3i3wA:
undetectable		 3sudC-3i3wA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ARG A 244
GLY A 240
SER A  52
ALA A 100
ASN A 108
 SEP  A 101 ( 4.1A)
SEP  A 101 ( 3.3A)
None
SEP  A 101 ( 3.6A)
None
 1.34A 3t7sB-3i3wA:
undetectable		 3t7sB-3i3wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ARG A 244
GLY A 240
SER A  52
ALA A 100
ASN A 108
 SEP  A 101 ( 4.1A)
SEP  A 101 ( 3.3A)
None
SEP  A 101 ( 3.6A)
None
 1.36A 3t7sC-3i3wA:
undetectable		 3t7sC-3i3wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ARG A 244
GLY A 240
SER A  52
ALA A 100
ASN A 108
 SEP  A 101 ( 4.1A)
SEP  A 101 ( 3.3A)
None
SEP  A 101 ( 3.6A)
None
 1.33A 3t7sD-3i3wA:
undetectable		 3t7sD-3i3wA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_B_FOZB316_0
(THYMIDYLATE SYNTHASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 LEU A 309
ILE A 328
GLY A 279
TYR A 291
ALA A 265
 None
 0.93A 3uwlB-3i3wA:
undetectable		 3uwlB-3i3wA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_A_ADNA401_1
(ADENOSINE KINASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ASN A 205
GLY A 182
ALA A 203
GLY A 216
ASP A 178
 None
 0.93A 4dc3A-3i3wA:
undetectable		 4dc3A-3i3wA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMA_A_CXXA603_1
(TRANSPORTER)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 11 VAL A  44
ALA A  92
PHE A  96
SER A 114
SER A 115
 None
 1.29A 4mmaA-3i3wA:
undetectable		 4mmaA-3i3wA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NTX_A_AMRA509_1
(ACID-SENSING ION
CHANNEL 1
BASIC PHOSPHOLIPASE
A2 HOMOLOG TX-BETA)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 6 ASP A 243
ASP A 241
ASN A 103
ARG A  11
 ZN  A 900 (-2.7A)
ZN  A 900 (-2.8A)
None
SEP  A 101 ( 2.9A)
 1.08A 4ntxA-3i3wA:
2.6
4ntxC-3i3wA:
undetectable		 4ntxA-3i3wA:
21.27
4ntxC-3i3wA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKB_A_198A1002_1
(ANDROGEN RECEPTOR)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 GLY A  54
GLN A  48
VAL A  46
THR A  24
ILE A  19
 None
 1.41A 4okbA-3i3wA:
undetectable		 4okbA-3i3wA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ASP A 337
LEU A 346
ILE A 343
VAL A 177
LEU A 238
 None
 1.09A 4y8wA-3i3wA:
undetectable		 4y8wA-3i3wA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ASP A 337
LEU A 346
ILE A 343
VAL A 177
LEU A 238
 None
 1.09A 4y8wB-3i3wA:
undetectable		 4y8wB-3i3wA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		3 / 3 ASN A 116
SER A 114
ARG A 306
 None
 0.72A 5b2qA-3i3wA:
undetectable		 5b2qA-3i3wA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 5 THR A 283
GLY A 279
HIS A 326
ASP A 258
 None
None
SEP  A 101 ( 3.7A)
None
 0.95A 5c0oH-3i3wA:
undetectable		 5c0oH-3i3wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_G_EVPG2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 6 GLU A  13
GLY A 216
ARG A 244
GLY A 240
 None
None
SEP  A 101 ( 4.1A)
SEP  A 101 ( 3.3A)
 0.84A 5cdnA-3i3wA:
2.5
5cdnB-3i3wA:
undetectable		 5cdnA-3i3wA:
23.52
5cdnB-3i3wA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 7 TYR A  40
ALA A  92
GLY A  95
SER A 114
GLY A 117
 None
 1.34A 5e26A-3i3wA:
undetectable
5e26B-3i3wA:
undetectable		 5e26A-3i3wA:
21.78
5e26B-3i3wA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHI_C_SAMC4000_0
(NS5
METHYLTRANSFERASE
DENGUE VIRUS)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 GLY A 279
GLY A 259
GLY A 257
GLY A 321
ASP A 249
 None
 0.96A 5ehiC-3i3wA:
undetectable		 5ehiC-3i3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 LEU A 309
ILE A 328
GLY A 279
TYR A 291
ALA A 265
 None
 0.89A 5j7wC-3i3wA:
undetectable		 5j7wC-3i3wA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J7W_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		5 / 12 ILE A 328
GLY A 279
TYR A 291
ILE A 319
ALA A 265
 None
 1.03A 5j7wD-3i3wA:
undetectable		 5j7wD-3i3wA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 6 ASP A 305
ASP A 258
ARG A 300
GLN A 281
 None
 1.24A 5l6eA-3i3wA:
undetectable		 5l6eA-3i3wA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 3i3w PHOSPHOGLUCOSAMINE
MUTASE
(Francisella
tularensis) 		4 / 7 ASP A 337
THR A 341
LEU A 339
VAL A  78
 None
 1.13A 5ov9A-3i3wA:
undetectable		 5ov9A-3i3wA:
22.36