SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i45'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.96A 1dfoA-3i45A:
undetectable		 1dfoA-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.96A 1dfoB-3i45A:
4.7		 1dfoB-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.96A 1dfoC-3i45A:
undetectable		 1dfoC-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.96A 1dfoD-3i45A:
4.2		 1dfoD-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.94A 1eqbA-3i45A:
undetectable		 1eqbA-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.94A 1eqbB-3i45A:
undetectable		 1eqbB-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.95A 1eqbC-3i45A:
undetectable		 1eqbC-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A  41
GLY A  39
LEU A  47
ALA A  38
PHE A 320
 None
 0.94A 1eqbD-3i45A:
2.7		 1eqbD-3i45A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_2_BO221405_1
(PROTEASOME COMPONENT
PRE3)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 11 THR A 292
ALA A 295
SER A 286
GLY A  27
SER A 103
 None
 1.19A 2f162-3i45A:
undetectable		 2f162-3i45A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 11 THR A 292
ALA A 295
SER A 286
GLY A  27
SER A 103
 None
 1.19A 2f16N-3i45A:
undetectable		 2f16N-3i45A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 5 ALA A 137
TRP A 145
LEU A 167
ALA A 138
 None
 1.01A 2jstA-3i45A:
undetectable
2jstB-3i45A:
undetectable		 2jstA-3i45A:
10.30
2jstB-3i45A:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_3
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 TYR A 240
ILE A  17
GLY A 155
ASN A 151
VAL A  85
 None
 1.17A 2nyrB-3i45A:
4.3		 2nyrB-3i45A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 5 GLN A 335
THR A 337
THR A 294
LEU A 287
 None
 1.30A 2zj0A-3i45A:
5.0		 2zj0A-3i45A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 LEU A 165
MET A 132
ALA A 131
VAL A 365
LEU A 327
 None
 1.35A 3b0wB-3i45A:
undetectable		 3b0wB-3i45A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 5 GLN A 335
THR A 337
THR A 294
LEU A 287
 None
 1.31A 3ce6A-3i45A:
5.1		 3ce6A-3i45A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 5 GLN A 335
THR A 337
THR A 294
LEU A 287
 None
 1.28A 3ce6C-3i45A:
5.8		 3ce6C-3i45A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		3 / 3 ARG A 170
GLU A 136
ASP A 356
 None
 0.76A 3g2oA-3i45A:
undetectable		 3g2oA-3i45A:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 7 GLU A 237
TYR A 154
PHE A 208
TYR A 240
 None
NIO  A 500 (-3.6A)
NIO  A 500 (-3.4A)
None
 1.30A 3ku9B-3i45A:
2.5		 3ku9B-3i45A:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_N_BO2N1404_1
(PROTEASOME COMPONENT
PRE3)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 11 THR A 292
ALA A 295
SER A 286
GLY A  27
SER A 103
 None
 1.21A 3mg0N-3i45A:
undetectable		 3mg0N-3i45A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 6 PHE A 300
ILE A   6
ARG A   7
VAL A  98
 None
 1.42A 4mk4B-3i45A:
3.7		 4mk4B-3i45A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 6 LEU A  41
GLU A  48
VAL A  74
ALA A  76
 None
 0.89A 4nkxA-3i45A:
undetectable		 4nkxA-3i45A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA208_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		4 / 4 ALA A 131
ALA A 134
ALA A 135
ALA A 138
 None
 0.13A 4oaeA-3i45A:
undetectable		 4oaeA-3i45A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 ALA A 248
PHE A 270
TYR A 274
GLY A 289
THR A 235
 None
 1.17A 5jlcA-3i45A:
undetectable		 5jlcA-3i45A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 12 THR A  21
ASP A  54
LEU A  87
ASN A  12
PRO A 105
 None
None
None
None
NIO  A 500 (-4.7A)
 1.48A 5ybbB-3i45A:
3.3		 5ybbB-3i45A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		5 / 11 THR A 147
PHE A 204
ALA A 130
THR A 126
THR A 107
 None
 1.26A 6efnA-3i45A:
2.4		 6efnA-3i45A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN
(Rhodospirillum
rubrum) 		3 / 3 HIS A  75
ARG A  45
ILE A   6
 None
 0.76A 6fgdA-3i45A:
3.6		 6fgdA-3i45A:
21.81