SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i47'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		4 / 7 LEU A  91
ALA A 120
ALA A 104
PHE A  61
 None
 0.86A 2vcvG-3i47A:
undetectable		 2vcvG-3i47A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_P_ASDP1224_1
(GLUTATHIONE
S-TRANSFERASE A3)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		4 / 8 LEU A  91
ALA A 120
ALA A 104
PHE A  61
 None
 0.84A 2vcvP-3i47A:
undetectable		 2vcvP-3i47A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		5 / 11 GLY A 113
ASN A  26
SER A  62
LEU A  91
LEU A  88
 None
 1.38A 3ndvC-3i47A:
undetectable
3ndvD-3i47A:
undetectable		 3ndvC-3i47A:
20.69
3ndvD-3i47A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		5 / 12 LEU A 162
GLY A 112
ALA A 115
ALA A 119
LEU A 179
 None
 0.98A 3p5nA-3i47A:
undetectable		 3p5nA-3i47A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		5 / 12 LEU A 162
GLY A 112
ALA A 115
ALA A 119
LEU A 179
 None
 0.98A 3p5nB-3i47A:
undetectable		 3p5nB-3i47A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		4 / 7 PHE A 192
SER A 198
ALA A 197
LEU A 194
 None
 1.12A 5dzkD-3i47A:
14.5
5dzkR-3i47A:
undetectable		 5dzkD-3i47A:
23.44
5dzkR-3i47A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H2U_A_1N1A501_1
(PROTEIN-TYROSINE
KINASE 6)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		6 / 12 ALA A 120
LEU A  91
GLY A 113
GLU A 136
LEU A  88
GLY A  89
 None
 1.44A 5h2uA-3i47A:
undetectable		 5h2uA-3i47A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		5 / 11 ALA A 118
ALA A 120
VAL A 106
GLY A 112
GLY A 113
 None
 0.95A 5lf7K-3i47A:
undetectable
5lf7L-3i47A:
undetectable		 5lf7K-3i47A:
21.43
5lf7L-3i47A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		5 / 11 ALA A 118
ALA A 120
VAL A 106
GLY A 112
GLY A 113
 None
 0.96A 5lf7Y-3i47A:
undetectable
5lf7Z-3i47A:
undetectable		 5lf7Y-3i47A:
21.43
5lf7Z-3i47A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 3i47 ENOYL COA
HYDRATASE/ISOMERASE
(CROTONASE)
(Legionella
pneumophila) 		4 / 5 TYR A 149
VAL A 145
LEU A  88
SER A  94
 None
 1.19A 6a7pA-3i47A:
3.7		 6a7pA-3i47A:
19.39