SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 10 ALA A  46
ASN A 122
ALA A 175
LEU A  87
ILE A 121
 None
 1.32A 1claA-3i4eA:
undetectable		 1claA-3i4eA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		4 / 4 HIS A 181
VAL A 152
THR A 348
LEU A  66
 None
 1.18A 1oq5A-3i4eA:
undetectable		 1oq5A-3i4eA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 125
THR A 126
ILE A 151
GLY A  49
LEU A  45
 None
 0.71A 1qknA-3i4eA:
undetectable		 1qknA-3i4eA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RI4_A_SAMA299_0
(MRNA CAPPING ENZYME)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 12 GLY A 273
ALA A 228
ASP A 281
GLN A 305
TYR A 279
 None
 1.19A 1ri4A-3i4eA:
undetectable		 1ri4A-3i4eA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		4 / 6 LEU A  56
ALA A 149
LEU A  53
SER A 178
 None
 1.27A 1tyrA-3i4eA:
undetectable		 1tyrA-3i4eA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		4 / 7 ALA A 275
TYR A 276
ARG A 272
TYR A 294
 None
 1.17A 2ajvH-3i4eA:
undetectable
2ajvL-3i4eA:
undetectable		 2ajvH-3i4eA:
18.97
2ajvL-3i4eA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		4 / 6 ASN A 122
ILE A  85
VAL A  78
ALA A 149
 None
 0.92A 2j5mA-3i4eA:
undetectable		 2j5mA-3i4eA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 12 ILE A 302
ILE A  23
LEU A 210
VAL A 207
ILE A 283
 None
 1.07A 4m2xG-3i4eA:
undetectable		 4m2xG-3i4eA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJE_A_TOYA202_1
(AADB)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		4 / 8 ASP A 184
ASP A 231
GLU A 233
TYR A 313
 None
 0.89A 4xjeA-3i4eA:
undetectable		 4xjeA-3i4eA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_A_AG2A505_1
(HOMOSPERMIDINE
SYNTHASE)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 12 ALA A 235
PRO A 264
ASP A 184
LEU A 200
THR A 230
 None
 1.26A 4xqeA-3i4eA:
0.0		 4xqeA-3i4eA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XQE_B_AG2B504_1
(HOMOSPERMIDINE
SYNTHASE)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 12 ALA A 235
PRO A 264
ASP A 184
LEU A 200
THR A 230
 None
 1.27A 4xqeB-3i4eA:
0.1		 4xqeB-3i4eA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XRG_B_AG2B502_1
(HOMOSPERMIDINE
SYNTHASE)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 12 ALA A 235
PRO A 264
ASP A 184
LEU A 200
THR A 230
 None
 1.26A 4xrgB-3i4eA:
0.2		 4xrgB-3i4eA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CFS_A_TOYA203_1
(AAD(2''),GENTAMICIN
2''-NUCLEOTIDYLTRANS
FERASE,GENTAMICIN
RESISTANCE PROTEIN)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		4 / 8 ASP A 184
ASP A 231
GLU A 233
TYR A 313
 None
 0.93A 5cfsA-3i4eA:
undetectable		 5cfsA-3i4eA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0Y_A_FOLA201_0
(CONSERVED
HYPOTHETICAL
MEMBRANE PROTEIN)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		5 / 12 LEU A 168
GLY A 160
ASP A 184
THR A 230
VAL A 180
 None
 1.40A 5d0yA-3i4eA:
undetectable		 5d0yA-3i4eA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 3i4e ISOCITRATE LYASE
(Burkholderia
pseudomallei) 		4 / 9 VAL A 180
THR A 224
ASP A 218
ILE A 173
 None
 0.92A 5lg3I-3i4eA:
undetectable		 5lg3I-3i4eA:
20.18