SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4g'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		5 / 12 PHE A 145
ALA A 217
ALA A 218
THR A 225
ARG A 224
 None
 1.13A 1cbrA-3i4gA:
undetectable		 1cbrA-3i4gA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBR_B_REAB200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE I)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		5 / 12 PHE A 145
ALA A 217
ALA A 218
THR A 225
ARG A 224
 None
 1.13A 1cbrB-3i4gA:
undetectable		 1cbrB-3i4gA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4002_1
(SERUM ALBUMIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 4 ARG A 147
ALA A 143
ALA A 195
GLU A 191
 None
 1.25A 1e7bA-3i4gA:
undetectable		 1e7bA-3i4gA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 8 TYR A 109
PHE A 105
GLY A  70
VAL A 299
 None
 1.10A 1gsfA-3i4gA:
2.9		 1gsfA-3i4gA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 8 TYR A 109
PHE A 105
GLY A  70
VAL A 299
 None
 1.10A 1gsfB-3i4gA:
2.6		 1gsfB-3i4gA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 8 TYR A 109
PHE A 105
GLY A  70
VAL A 299
 None
 1.10A 1gsfD-3i4gA:
2.9		 1gsfD-3i4gA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 7 GLU A 465
LEU A 257
TYR A 339
ILE A 250
 None
 0.96A 1tuvA-3i4gA:
undetectable		 1tuvA-3i4gA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_B_CFFB2434_1
(CHITINASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 6 TRP A 474
TYR A 157
ASP A 475
ARG A 462
 None
 1.42A 2a3bB-3i4gA:
undetectable		 2a3bB-3i4gA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 6 TYR A  68
GLY A  57
TYR A  60
ASP A  56
 None
None
EPE  A   1 (-4.6A)
None
 1.27A 2g72A-3i4gA:
undetectable		 2g72A-3i4gA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 5 ASP A 304
LEU A 305
MET A 468
ARG A 463
 EDO  A   4 (-3.3A)
None
None
None
 1.46A 2gj5A-3i4gA:
undetectable		 2gj5A-3i4gA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		5 / 12 SER A  95
ASN A  89
ALA A  81
THR A 376
VAL A 518
 None
 1.25A 2nniA-3i4gA:
undetectable		 2nniA-3i4gA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PH9_A_GNTA301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 7 TYR A 473
TRP A 531
TYR A 109
ILE A 106
 None
 1.28A 2ph9A-3i4gA:
undetectable
2ph9B-3i4gA:
undetectable		 2ph9A-3i4gA:
18.41
2ph9B-3i4gA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 7 ILE A 464
ARG A 463
PRO A 401
GLY A 470
 None
 1.14A 2pnjB-3i4gA:
undetectable		 2pnjB-3i4gA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEB_A_HSMA145_1
(D7R4 PROTEIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 7 ILE A 432
ARG A 436
ASP A 334
GLU A 310
 None
 1.12A 2qebA-3i4gA:
undetectable		 2qebA-3i4gA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		5 / 12 ASP A 334
ILE A 341
ILE A 457
ILE A 432
ARG A 336
 None
 1.44A 3phaB-3i4gA:
undetectable		 3phaB-3i4gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 6 VAL A 441
TYR A 254
GLU A 461
ILE A 464
 None
 1.06A 3q5sA-3i4gA:
undetectable		 3q5sA-3i4gA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEM_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		5 / 12 ALA A 467
ASN A  80
ILE A 250
ARG A 336
PHE A 258
 None
 1.41A 3wemA-3i4gA:
undetectable		 3wemA-3i4gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WEN_A_ACRA1001_1
(ALPHA-GLUCOSIDASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		5 / 12 ALA A 467
ASN A  80
ILE A 250
ARG A 336
PHE A 258
 None
 1.39A 3wenA-3i4gA:
undetectable		 3wenA-3i4gA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_2
(SEPIAPTERIN
REDUCTASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		3 / 3 LEU A 367
MET A 355
ASP A 304
 None
None
EDO  A   4 (-3.3A)
 0.58A 4j7xB-3i4gA:
undetectable		 4j7xB-3i4gA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 9 TYR A 473
LYS A 159
PHE A 523
ILE A 481
 None
 1.15A 4jvlA-3i4gA:
undetectable		 4jvlA-3i4gA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_MTLA804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 6 GLU A 310
ASP A 313
ASP A 332
ARG A 323
 None
 1.40A 4kcnA-3i4gA:
undetectable		 4kcnA-3i4gA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 6 GLU A 310
ASP A 313
ASP A 332
ARG A 323
 None
 1.40A 4kcnB-3i4gA:
undetectable		 4kcnB-3i4gA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		5 / 12 MET A 380
THR A 282
TYR A  68
VAL A  58
LEU A 289
 None
EDO  A   2 ( 4.5A)
None
None
None
 1.32A 4qztA-3i4gA:
undetectable		 4qztA-3i4gA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 8 GLN A 425
ILE A 423
GLY A 426
ASN A 433
 None
 1.06A 5hwaA-3i4gA:
undetectable		 5hwaA-3i4gA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 6 ASP A  83
ILE A  72
TYR A  68
TYR A  60
 None
None
None
EPE  A   1 (-4.6A)
 1.29A 5ih0A-3i4gA:
undetectable		 5ih0A-3i4gA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 8 TYR A 412
ILE A 423
THR A 431
ILE A 432
 None
 0.83A 5mzrE-3i4gA:
4.2		 5mzrE-3i4gA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB311_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 4 PHE A 378
PRO A 496
TYR A 306
TYR A 324
 None
 1.27A 5uunB-3i4gA:
1.9		 5uunB-3i4gA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWJ_B_GLYB710_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		4 / 5 ARG A 116
ARG A 147
GLY A 118
ASN A 121
 EDO  A   6 (-3.5A)
None
None
None
 1.40A 6dwjB-3i4gA:
undetectable
6dwjD-3i4gA:
2.2		 6dwjB-3i4gA:
22.45
6dwjD-3i4gA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA821_0
(GEPHYRIN)		 3i4g SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN BF1063
(Bacteroides
fragilis) 		3 / 3 ARG A 524
PHE A 523
GLY A  97
 None
 0.70A 6fgdA-3i4gA:
undetectable		 6fgdA-3i4gA:
21.56