SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 SER A 143
ALA A  84
THR A 117
ILE A  89
 None
 0.82A 1c9sI-3i4iA:
undetectable
1c9sJ-3i4iA:
undetectable		 1c9sI-3i4iA:
16.44
1c9sJ-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.79A 1c9sU-3i4iA:
undetectable
1c9sV-3i4iA:
undetectable		 1c9sU-3i4iA:
16.44
1c9sV-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 4 VAL A 176
TRP A 105
TRP A 153
 None
 1.41A 1gmkC-3i4iA:
undetectable
1gmkD-3i4iA:
undetectable		 1gmkC-3i4iA:
6.19
1gmkD-3i4iA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_A_TRPA81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 7 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.78A 1gtnA-3i4iA:
undetectable
1gtnK-3i4iA:
undetectable		 1gtnA-3i4iA:
16.44
1gtnK-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_B_TRPB81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 SER A 143
ALA A  84
THR A 117
ILE A  89
 None
 0.77A 1gtnA-3i4iA:
undetectable
1gtnB-3i4iA:
undetectable		 1gtnA-3i4iA:
16.44
1gtnB-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_P_TRPP81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.79A 1gtnP-3i4iA:
undetectable
1gtnQ-3i4iA:
undetectable		 1gtnP-3i4iA:
16.44
1gtnQ-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_A_DVAA6_0
(MINI-GRAMICIDIN A)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 ALA A 197
VAL A 191
TRP A 194
 None
 0.82A 1kqeA-3i4iA:
undetectable
1kqeE-3i4iA:
undetectable		 1kqeA-3i4iA:
3.98
1kqeE-3i4iA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_B_DVAB6_0
(MINI-GRAMICIDIN A)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 ALA A 197
VAL A 191
TRP A 194
 None
 0.83A 1kqeB-3i4iA:
undetectable
1kqeD-3i4iA:
undetectable		 1kqeB-3i4iA:
3.98
1kqeD-3i4iA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_D_DVAD6_0
(MINI-GRAMICIDIN A)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 TRP A 194
ALA A 197
VAL A 191
 None
 0.84A 1kqeB-3i4iA:
undetectable
1kqeD-3i4iA:
undetectable		 1kqeB-3i4iA:
3.98
1kqeD-3i4iA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQE_E_DVAE6_0
(MINI-GRAMICIDIN A)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 TRP A 194
ALA A 197
VAL A 191
 None
 0.84A 1kqeA-3i4iA:
undetectable
1kqeE-3i4iA:
undetectable		 1kqeA-3i4iA:
3.98
1kqeE-3i4iA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MIC_A_DVAA6_0
(GRAMICIDIN A)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 ALA A 197
VAL A 191
TRP A 194
 None
 0.90A 1micA-3i4iA:
undetectable
1micB-3i4iA:
undetectable		 1micA-3i4iA:
6.19
1micB-3i4iA:
6.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.80A 1utdB-3i4iA:
undetectable
1utdC-3i4iA:
undetectable		 1utdB-3i4iA:
16.44
1utdC-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_F_TRPF81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.79A 1utdF-3i4iA:
undetectable
1utdG-3i4iA:
undetectable		 1utdF-3i4iA:
16.44
1utdG-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_I_TRPI81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.79A 1utdI-3i4iA:
undetectable
1utdJ-3i4iA:
undetectable		 1utdI-3i4iA:
16.44
1utdJ-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_J_TRPJ81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 8 ALA A  84
THR A 117
ILE A  89
SER A 143
 None
 0.78A 1utdJ-3i4iA:
undetectable
1utdK-3i4iA:
undetectable		 1utdJ-3i4iA:
16.44
1utdK-3i4iA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 ILE A 148
ASP A 145
PHE A 140
 None
 0.66A 1uwjB-3i4iA:
undetectable		 1uwjB-3i4iA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		4 / 6 TRP A 160
TYR A 157
TYR A 124
ILE A 108
 None
 1.16A 2pgzD-3i4iA:
undetectable
2pgzE-3i4iA:
undetectable		 2pgzD-3i4iA:
20.83
2pgzE-3i4iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		5 / 12 PHE A 112
PHE A 122
ALA A  84
ALA A 150
MET A  81
 None
 1.01A 2x2nB-3i4iA:
undetectable		 2x2nB-3i4iA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 ARG A  80
ASP A 209
TRP A 210
 None
CA  A1001 (-3.4A)
None
 0.26A 4xdqA-3i4iA:
21.4		 4xdqA-3i4iA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		5 / 12 ILE A 108
LEU A  76
GLY A  75
ALA A 212
VAL A 211
 None
 1.17A 5x66F-3i4iA:
undetectable		 5x66F-3i4iA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 3i4i 1,3-1,4-BETA-GLUCANA
SE
(uncultured
murine
large
bowel
bacterium
BAC
14) 		3 / 3 ILE A  50
THR A  51
PRO A 187
 None
 0.55A 6ncsA-3i4iA:
undetectable		 6ncsA-3i4iA:
24.28