SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		6 / 12 GLY A  46
ILE A 312
ALA A 265
GLY A 266
ALA A  41
ILE A  43
 None
 1.16A 1bx4A-3i4jA:
undetectable		 1bx4A-3i4jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 6 ASN A 171
ALA A 210
GLY A 212
TYR A 213
 None
 0.91A 1c8lA-3i4jA:
undetectable		 1c8lA-3i4jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 ALA A 196
ARG A 180
ILE A 226
LEU A 183
ILE A 125
 None
 1.33A 1d1gA-3i4jA:
undetectable		 1d1gA-3i4jA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDS_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 ILE A 409
ALA A 411
ASP A 415
LEU A 418
LEU A 353
 None
 1.19A 1ddsB-3i4jA:
undetectable		 1ddsB-3i4jA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 5 LEU A 352
GLU A 197
ALA A 205
LEU A 353
 None
 1.16A 1eta1-3i4jA:
undetectable		 1eta1-3i4jA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_2_T442129_1
(TRANSTHYRETIN)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 5 LEU A 352
GLU A 197
ALA A 205
LEU A 353
 None
 1.15A 1eta2-3i4jA:
undetectable		 1eta2-3i4jA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 6 LEU A 352
GLU A 197
ALA A 205
LEU A 353
 None
 1.12A 1etb1-3i4jA:
undetectable		 1etb1-3i4jA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 6 ASN A 171
ALA A 210
GLY A 212
TYR A 213
 None
 0.89A 1gfzA-3i4jA:
undetectable		 1gfzA-3i4jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 8 GLY A 238
ARG A 239
LEU A 407
VAL A 309
 None
 0.99A 1gsfC-3i4jA:
undetectable		 1gsfC-3i4jA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 GLY A 266
ALA A 265
VAL A 313
GLY A 306
ILE A  43
 None
 1.00A 2avsB-3i4jA:
undetectable		 2avsB-3i4jA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_A_SAMA1300_0
(UPF0088 PROTEIN
AQ_165)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 LEU A 352
GLY A 350
GLY A 326
LEU A 402
ALA A 206
 None
 0.83A 2egvA-3i4jA:
undetectable		 2egvA-3i4jA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 LEU A 352
GLY A 350
GLY A 326
LEU A 402
ALA A 206
 None
 0.85A 2egvB-3i4jA:
undetectable		 2egvB-3i4jA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HW2_A_RFPA1200_1
(RIFAMPIN ADP-RIBOSYL
TRANSFERASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 PHE A  22
GLY A 404
GLY A 332
LEU A 333
LEU A 336
 None
 1.02A 2hw2A-3i4jA:
undetectable		 2hw2A-3i4jA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA502_0
(FERROCHELATASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 8 PRO A 406
SER A 408
VAL A  40
GLY A 262
 None
 1.03A 2qd3A-3i4jA:
2.0		 2qd3A-3i4jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 8 PRO A 406
SER A 408
VAL A  40
GLY A 262
 None
 0.97A 2qd5A-3i4jA:
undetectable		 2qd5A-3i4jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BCR_A_AZZA940_1
(GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 5 ASN A 171
ALA A 210
GLY A 212
TYR A 213
 None
 0.95A 3bcrA-3i4jA:
undetectable		 3bcrA-3i4jA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 6 ASN A 171
ALA A 210
GLY A 212
TYR A 213
 None
 0.95A 3dd1A-3i4jA:
undetectable		 3dd1A-3i4jA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 6 ASN A 171
ALA A 210
GLY A 212
TYR A 213
 None
 0.93A 3dd1B-3i4jA:
undetectable		 3dd1B-3i4jA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 HIS A  45
LEU A  23
GLY A  34
LEU A 353
ALA A  41
 None
 1.20A 3i5uA-3i4jA:
undetectable		 3i5uA-3i4jA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 HIS A  45
LEU A  23
GLY A  34
LEU A 353
ALA A  41
 None
 1.20A 3i5uB-3i4jA:
undetectable		 3i5uB-3i4jA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		6 / 12 GLY A 236
PRO A 198
VAL A 199
ALA A 230
ALA A 257
LEU A 244
 None
 1.20A 3mteB-3i4jA:
undetectable		 3mteB-3i4jA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 GLY A 266
ALA A 265
VAL A 313
GLY A 306
ILE A  43
 None
 1.07A 3nu5B-3i4jA:
undetectable		 3nu5B-3i4jA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_2
(PROTEASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 10 GLY A 266
ALA A 265
VAL A 313
GLY A 306
ILE A  43
 None
 1.00A 3nu6B-3i4jA:
undetectable		 3nu6B-3i4jA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 9 GLY A 266
ALA A 265
VAL A 313
GLY A 306
ILE A  43
 None
 0.96A 3oxvC-3i4jA:
undetectable		 3oxvC-3i4jA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 GLY A 236
PRO A 198
ALA A 230
ALA A 257
LEU A 244
 None
 1.03A 3p2kA-3i4jA:
undetectable		 3p2kA-3i4jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 GLY A 236
PRO A 198
VAL A 199
ALA A 257
LEU A 244
 None
 1.17A 3p2kB-3i4jA:
undetectable		 3p2kB-3i4jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		6 / 12 GLY A 236
PRO A 198
VAL A 199
ALA A 230
ALA A 257
LEU A 244
 None
 1.15A 3p2kD-3i4jA:
undetectable		 3p2kD-3i4jA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 10 TYR A 214
GLU A 215
SER A 250
ALA A 230
GLU A 232
 None
 1.41A 3u6tA-3i4jA:
undetectable		 3u6tA-3i4jA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		3 / 3 ARG A 339
PHE A 340
PRO A 341
 None
 0.89A 3zoaB-3i4jA:
undetectable		 3zoaB-3i4jA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 LEU A 407
GLY A  44
ALA A  41
PHE A  22
LEU A  32
 None
 1.16A 4hytA-3i4jA:
undetectable		 4hytA-3i4jA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 LEU A 407
GLY A  44
ALA A  41
PHE A  22
LEU A  32
 None
 1.19A 4hytC-3i4jA:
undetectable		 4hytC-3i4jA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 8 PRO A 406
SER A 408
VAL A  40
GLY A 262
 None
 1.03A 4mk4A-3i4jA:
undetectable		 4mk4A-3i4jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_B_15UB301_1
(THROMBIN HEAVY CHAIN)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 ALA A 101
ALA A  94
VAL A  95
GLY A 260
GLY A  98
 None
None
None
None
SO4  A 431 (-3.6A)
 0.98A 4rn6B-3i4jA:
undetectable		 4rn6B-3i4jA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 5 ILE A 256
PHE A 290
SER A 104
ALA A 109
 None
 1.10A 5msdA-3i4jA:
2.6		 5msdA-3i4jA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 10 LEU A 352
PRO A 405
GLY A 350
GLY A 326
ALA A 206
 None
 1.18A 5o96E-3i4jA:
undetectable
5o96F-3i4jA:
undetectable		 5o96E-3i4jA:
21.76
5o96F-3i4jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_G_SAMG501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 11 LEU A 352
GLY A 350
GLY A 326
LEU A 402
ALA A 206
 None
 0.98A 5o96G-3i4jA:
undetectable		 5o96G-3i4jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 10 LEU A 352
GLY A 350
GLY A 326
LEU A 402
ALA A 206
 None
 1.08A 5o96G-3i4jA:
undetectable
5o96H-3i4jA:
undetectable		 5o96G-3i4jA:
21.76
5o96H-3i4jA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_A_SAMA501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 12 GLY A  18
ASP A 415
GLY A 416
ASP A  33
LEU A 329
 None
 1.07A 5wwsA-3i4jA:
undetectable		 5wwsA-3i4jA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		4 / 7 ALA A 271
GLY A 272
LEU A 273
GLY A 236
 None
 0.70A 6nm4A-3i4jA:
undetectable		 6nm4A-3i4jA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3i4j AMINOTRANSFERASE,
CLASS III
(Deinococcus
radiodurans) 		5 / 9 ILE A  43
ALA A 265
GLY A 262
LEU A 263
ARG A  47
 None
 1.09A 6nm4B-3i4jA:
undetectable		 6nm4B-3i4jA:
20.19