SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 11 SER A  31
GLY A  57
LEU A 305
GLY A  25
GLU A 329
 SER  A  31 ( 0.0A)
GLY  A  57 ( 0.0A)
LEU  A 305 ( 0.6A)
GLY  A  25 ( 0.0A)
GLU  A 329 ( 0.6A)
 1.45A 1iolA-3i4kA:
3.3		 1iolA-3i4kA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RLB_E_REAE176_1
(RETINOL BINDING
PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 10 LEU A 305
ALA A 143
LEU A 330
ASP A 251
PHE A  26
 LEU  A 305 ( 0.6A)
ALA  A 143 ( 0.0A)
LEU  A 330 ( 0.6A)
ASP  A 251 ( 0.6A)
PHE  A  26 ( 1.3A)
 1.30A 1rlbE-3i4kA:
undetectable		 1rlbE-3i4kA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 8 GLU A 329
HIS A 279
GLU A 252
ASP A 200
 GLU  A 329 ( 0.6A)
HIS  A 279 ( 1.0A)
GLU  A 252 ( 0.6A)
ASP  A 200 ( 0.6A)
 1.22A 1s3zA-3i4kA:
1.9
1s3zB-3i4kA:
1.9		 1s3zA-3i4kA:
17.51
1s3zB-3i4kA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 GLY A  49
ASN A  45
ASP A 116
ALA A 113
ALA A 109
 GLY  A  49 ( 0.0A)
ASN  A  45 ( 0.6A)
ASP  A 116 ( 0.6A)
ALA  A 113 ( 0.0A)
ALA  A 109 ( 0.0A)
 1.28A 2br4B-3i4kA:
undetectable		 2br4B-3i4kA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 8 GLY A  51
GLY A 310
THR A 311
ALA A 312
ALA A 313
 GLY  A  51 ( 0.0A)
GLY  A 310 ( 0.0A)
THR  A 311 ( 0.8A)
ALA  A 312 ( 0.0A)
ALA  A 313 ( 0.0A)
 1.17A 2ej3A-3i4kA:
undetectable		 2ej3A-3i4kA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AXZ_A_ADNA401_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 LEU A 305
SER A 304
GLY A 307
GLY A 310
GLY A 332
 LEU  A 305 ( 0.6A)
SER  A 304 ( 0.0A)
GLY  A 307 ( 0.0A)
GLY  A 310 ( 0.0A)
GLY  A 332 ( 0.0A)
 0.95A 3axzA-3i4kA:
undetectable		 3axzA-3i4kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		3 / 3 SER A 285
GLY A 281
SER A 314
 SER  A 285 ( 0.0A)
GLY  A 281 ( 0.0A)
SER  A 314 ( 0.0A)
 0.55A 3loqA-3i4kA:
3.7		 3loqA-3i4kA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_A_CAMA423_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 10 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.30A 3lxiA-3i4kA:
undetectable		 3lxiA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 11 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.29A 3lxiB-3i4kA:
undetectable		 3lxiB-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 5 TYR A 105
VAL A  54
SER A 304
GLY A  58
 TYR  A 105 ( 1.3A)
VAL  A  54 ( 0.6A)
SER  A 304 ( 0.0A)
GLY  A  58 ( 0.0A)
 1.49A 3v4tA-3i4kA:
undetectable
3v4tD-3i4kA:
undetectable		 3v4tA-3i4kA:
23.42
3v4tD-3i4kA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ASCA904_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 6 PHE A 331
LEU A 330
PRO A 333
GLU A 306
 PHE  A 331 ( 1.3A)
LEU  A 330 ( 0.6A)
PRO  A 333 ( 1.1A)
GLU  A 306 ( 0.5A)
 1.39A 3vlnA-3i4kA:
undetectable		 3vlnA-3i4kA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 10 ALA A 220
ARG A 189
LEU A 217
LEU A 187
ILE A 199
 ALA  A 220 ( 0.0A)
ARG  A 189 ( 0.6A)
LEU  A 217 ( 0.6A)
LEU  A 187 ( 0.6A)
ILE  A 199 ( 0.4A)
 1.19A 3wdmB-3i4kA:
undetectable		 3wdmB-3i4kA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 5 LEU A 360
GLY A 359
ILE A  48
VAL A  47
 LEU  A 360 ( 0.6A)
GLY  A 359 ( 0.0A)
ILE  A  48 ( 0.7A)
VAL  A  47 ( 0.6A)
 0.85A 3wriA-3i4kA:
undetectable		 3wriA-3i4kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRI_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 5 LEU A 360
GLY A 359
ILE A  48
VAL A  47
 LEU  A 360 ( 0.6A)
GLY  A 359 ( 0.0A)
ILE  A  48 ( 0.7A)
VAL  A  47 ( 0.6A)
 0.84A 3wriB-3i4kA:
undetectable		 3wriB-3i4kA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_A_CAMA424_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.28A 4c9kA-3i4kA:
undetectable		 4c9kA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9K_B_CAMB424_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.26A 4c9kB-3i4kA:
undetectable		 4c9kB-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_A_CAMA1419_0
(CYTOCHROME P450)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 8 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.27A 4c9nA-3i4kA:
undetectable		 4c9nA-3i4kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 11 GLY A 310
GLN A 316
PRO A 333
PHE A 345
ILE A 341
 GLY  A 310 ( 0.0A)
GLN  A 316 ( 0.6A)
PRO  A 333 ( 1.1A)
PHE  A 345 ( 1.3A)
ILE  A 341 ( 0.3A)
 1.13A 4j4vA-3i4kA:
undetectable		 4j4vA-3i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 11 ALA A 119
GLN A 316
PRO A 333
PHE A 345
ILE A 341
 ALA  A 119 ( 0.0A)
GLN  A 316 ( 0.6A)
PRO  A 333 ( 1.1A)
PHE  A 345 ( 1.3A)
ILE  A 341 ( 0.3A)
 1.43A 4j4vD-3i4kA:
undetectable
4j4vE-3i4kA:
undetectable		 4j4vD-3i4kA:
21.29
4j4vE-3i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_D_SVRD301_1
(NUCLEOCAPSID PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 11 GLY A 310
GLN A 316
PRO A 333
PHE A 345
ILE A 341
 GLY  A 310 ( 0.0A)
GLN  A 316 ( 0.6A)
PRO  A 333 ( 1.1A)
PHE  A 345 ( 1.3A)
ILE  A 341 ( 0.3A)
 1.27A 4j4vD-3i4kA:
undetectable
4j4vE-3i4kA:
undetectable		 4j4vD-3i4kA:
21.29
4j4vE-3i4kA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KF9_A_ACTA408_0
(GLUTATHIONE
S-TRANSFERASE
PROTEIN)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 6 TYR A 340
THR A 339
PRO A 333
PHE A 345
 TYR  A 340 ( 1.3A)
THR  A 339 ( 0.8A)
PRO  A 333 ( 1.1A)
PHE  A 345 ( 1.3A)
 1.30A 4kf9A-3i4kA:
undetectable		 4kf9A-3i4kA:
25.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O33_A_TZNA501_1
(PHOSPHOGLYCERATE
KINASE 1)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 GLY A 192
LEU A 187
LEU A 217
GLY A 221
VAL A 222
 GLY  A 192 ( 0.0A)
LEU  A 187 ( 0.6A)
LEU  A 217 ( 0.6A)
GLY  A 221 ( 0.0A)
VAL  A 222 ( 0.6A)
 0.81A 4o33A-3i4kA:
undetectable		 4o33A-3i4kA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PFJ_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 7 GLU A  52
THR A 311
HIS A  24
LEU A  20
 GLU  A  52 ( 0.6A)
THR  A 311 ( 0.8A)
HIS  A  24 ( 1.0A)
LEU  A  20 ( 0.6A)
 1.13A 4pfjA-3i4kA:
undetectable		 4pfjA-3i4kA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBS_A_DIFA502_1
(PENTALENIC ACID
SYNTHASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 LEU A 315
LEU A 274
SER A 320
THR A 321
ILE A 324
 LEU  A 315 ( 0.6A)
LEU  A 274 ( 0.6A)
SER  A 320 ( 0.0A)
THR  A 321 ( 0.8A)
ILE  A 324 ( 0.7A)
 1.30A 4ubsA-3i4kA:
undetectable		 4ubsA-3i4kA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 9 TYR A 340
LEU A 336
GLY A 332
THR A 303
VAL A  54
 TYR  A 340 ( 1.3A)
LEU  A 336 ( 0.6A)
GLY  A 332 ( 0.0A)
THR  A 303 (-0.8A)
VAL  A  54 ( 0.6A)
 1.39A 5cp4A-3i4kA:
undetectable		 5cp4A-3i4kA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 TYR A 105
MET A  69
LEU A  38
GLY A 307
ILE A 309
 TYR  A 105 ( 1.3A)
GLY  A  53 ( 3.5A)
LEU  A  38 ( 0.6A)
GLY  A 307 ( 0.0A)
ILE  A 309 ( 0.7A)
 1.03A 5d4uC-3i4kA:
undetectable		 5d4uC-3i4kA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 TYR A 105
ILE A  36
MET A  69
LEU A  38
ILE A 309
 TYR  A 105 ( 1.3A)
ILE  A  36 ( 0.7A)
GLY  A  53 ( 3.5A)
LEU  A  38 ( 0.6A)
ILE  A 309 ( 0.7A)
 0.96A 5d4uD-3i4kA:
undetectable		 5d4uD-3i4kA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 TYR A 105
MET A  69
LEU A  38
GLY A 307
ILE A 309
 TYR  A 105 ( 1.3A)
GLY  A  53 ( 3.5A)
LEU  A  38 ( 0.6A)
GLY  A 307 ( 0.0A)
ILE  A 309 ( 0.7A)
 0.98A 5d4uD-3i4kA:
undetectable		 5d4uD-3i4kA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIW_B_OAQB302_0
(SULFOTRANSFERASE)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		5 / 12 PRO A 177
ILE A 199
ASP A 180
ILE A 240
THR A 244
 PRO  A 177 ( 1.1A)
ILE  A 199 ( 0.4A)
ASP  A 180 ( 0.5A)
ILE  A 240 ( 0.6A)
THR  A 244 ( 0.8A)
 1.27A 5tiwB-3i4kA:
undetectable		 5tiwB-3i4kA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 3i4k MUCONATE LACTONIZING
ENZYME
(Corynebacterium
glutamicum) 		4 / 8 GLY A 310
ARG A 120
VAL A 112
ASP A 116
 GLY  A 310 ( 0.0A)
ARG  A 120 ( 0.6A)
VAL  A 112 ( 0.6A)
ASP  A 116 ( 0.6A)
 1.05A 5vlmA-3i4kA:
undetectable		 5vlmA-3i4kA:
19.53