SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_1
(PROTEIN (PROTEASE))		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.96A 1c6zA-3i4oA:
undetectable		 1c6zA-3i4oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.91A 1c6zB-3i4oA:
undetectable		 1c6zB-3i4oA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_3
(POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.86A 2avsB-3i4oA:
undetectable		 2avsB-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.97A 2f80A-3i4oA:
undetectable		 2f80A-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_2
(POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.98A 2f80B-3i4oA:
undetectable		 2f80B-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.95A 2f8gA-3i4oA:
undetectable		 2f8gA-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 1.15A 2f8gB-3i4oA:
undetectable		 2f8gB-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4L_A_TPVA403_2
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 1.08A 2o4lB-3i4oA:
undetectable		 2o4lB-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_1
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.92A 2o4sA-3i4oA:
undetectable		 2o4sA-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.98A 2pymA-3i4oA:
undetectable		 2pymA-3i4oA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.97A 2pynA-3i4oA:
undetectable		 2pynA-3i4oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.99A 2pynB-3i4oA:
undetectable		 2pynB-3i4oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.92A 2q63B-3i4oA:
undetectable		 2q63B-3i4oA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.89A 2q64A-3i4oA:
undetectable		 2q64A-3i4oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_1
(PROTEASE RETROPEPSIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.93A 2q64A-3i4oA:
undetectable		 2q64A-3i4oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.95A 2qakB-3i4oA:
undetectable		 2qakB-3i4oA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.98A 3bvbA-3i4oA:
undetectable		 3bvbA-3i4oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_1
(GAG-POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.90A 3jvyA-3i4oA:
undetectable		 3jvyA-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.92A 3jvyB-3i4oA:
undetectable		 3jvyB-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.93A 3jvyB-3i4oA:
undetectable		 3jvyB-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MWS_B_017B201_1
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.93A 3mwsA-3i4oA:
undetectable		 3mwsA-3i4oA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_1
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 1.04A 3nu5A-3i4oA:
undetectable		 3nu5A-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU5_B_478B401_2
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.96A 3nu5B-3i4oA:
undetectable		 3nu5B-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_2
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.90A 3nujB-3i4oA:
undetectable		 3nujB-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.90A 3nuoB-3i4oA:
undetectable		 3nuoB-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_1
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.94A 3oxcA-3i4oA:
undetectable		 3oxcA-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_1
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.94A 3oxvC-3i4oA:
undetectable		 3oxvC-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.95A 3oxxA-3i4oA:
undetectable		 3oxxA-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_1
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.94A 3oxxA-3i4oA:
undetectable		 3oxxA-3i4oA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.92A 3pwrB-3i4oA:
undetectable		 3pwrB-3i4oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.95A 3pwrB-3i4oA:
undetectable		 3pwrB-3i4oA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_2
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.98A 4jecB-3i4oA:
undetectable		 4jecB-3i4oA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		4 / 4 ILE A  68
VAL A  10
VAL A  54
ARG A  71
 None
 1.23A 4m6tA-3i4oA:
undetectable		 4m6tA-3i4oA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_2
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.92A 4njvD-3i4oA:
undetectable		 4njvD-3i4oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.91A 4rvjB-3i4oA:
undetectable		 4rvjB-3i4oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 9 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 0.91A 4rvjD-3i4oA:
undetectable		 4rvjD-3i4oA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T2Z_B_017B201_1
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  25
 None
 1.00A 5t2zA-3i4oA:
undetectable		 5t2zA-3i4oA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		5 / 12 GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 0.90A 6dh6A-3i4oA:
undetectable		 6dh6A-3i4oA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIL_B_TPVB201_1
(HIV-1 PROTEASE)		 3i4o TRANSLATION
INITIATION FACTOR
IF-1
(Mycobacterium
tuberculosis) 		6 / 12 LEU A  27
GLY A  66
ALA A  35
VAL A  14
ILE A  48
ILE A  25
 None
 1.09A 6dilB-3i4oA:
undetectable		 6dilB-3i4oA:
23.33