SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NNH_A_9CRA502_1 (CYTOCHROME P450 2C8)	3i4p	TRANSCRIPTIONAL REGULATOR, ASNC FAMILY (Agrobacterium fabrum)	5 / 12	ILE A 47 ILE A 38 LEU A 12 VAL A 20 VAL A 27	None	0.99A	2nnhA-3i4pA: undetectable	2nnhA-3i4pA: 16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_C_SVRC507_2 (PHOSPHOLIPASE A2)	3i4p	TRANSCRIPTIONAL REGULATOR, ASNC FAMILY (Agrobacterium fabrum)	4 / 6	VAL A 92 VAL A 93 ARG A 107 ARG A 49	None None None CL A 163 (-4.1A)	1.09A	3bjwF-3i4pA: undetectable	3bjwF-3i4pA: 19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6J_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3i4p	TRANSCRIPTIONAL REGULATOR, ASNC FAMILY (Agrobacterium fabrum)	3 / 3	MET A 41 ASP A 2 ARG A 10	None	1.05A	5z6jA-3i4pA: undetectable	5z6jA-3i4pA: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z6K_A_FOLA201_1 (DIHYDROFOLATE REDUCTASE)	3i4p	TRANSCRIPTIONAL REGULATOR, ASNC FAMILY (Agrobacterium fabrum)	3 / 3	MET A 41 ASP A 2 ARG A 10	None	1.14A	5z6kA-3i4pA: undetectable	5z6kA-3i4pA: 21.39

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2NNH_A_9CRA502_1","CYTOCHROME P450 2C8","3i4p","TRANSCRIPTIONAL REGULATOR, ASNC FAMILY","Agrobacterium fabrum",5,"ILE A  47;ILE A  38;LEU A  12;VAL A  20;VAL A  27","None","0.99A","2nnhA-3i4pA:undetectable","2nnhA-3i4pA:16.04"],["3BJW_C_SVRC507_2","PHOSPHOLIPASE A2;PHOSPHOLIPASE A2","3i4p","TRANSCRIPTIONAL REGULATOR, ASNC FAMILY","Agrobacterium fabrum",4,"VAL A  92;VAL A  93;ARG A 107;ARG A  49","None;None;None; CL A 163 (-4.1A)","1.09A","3bjwF-3i4pA:undetectable","3bjwF-3i4pA:19.25"],["5Z6J_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3i4p","TRANSCRIPTIONAL REGULATOR, ASNC FAMILY","Agrobacterium fabrum",3,"MET A  41;ASP A   2;ARG A  10","None","1.05A","5z6jA-3i4pA:undetectable","5z6jA-3i4pA:21.39"],["5Z6K_A_FOLA201_1","DIHYDROFOLATE REDUCTASE","3i4p","TRANSCRIPTIONAL REGULATOR, ASNC FAMILY","Agrobacterium fabrum",3,"MET A  41;ASP A   2;ARG A  10","None","1.14A","5z6kA-3i4pA:undetectable","5z6kA-3i4pA:21.39"]]