SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_A_SNLA502_2
(MINERALOCORTICOID
RECEPTOR)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 6 LEU B 938
LEU B 935
LEU B 956
LEU B 973
 None
 0.95A 2ab2A-3i4rB:
undetectable		 2ab2A-3i4rB:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 6 HIS B1004
THR B1007
LEU B1054
LEU B1031
 None
 1.18A 3bgdA-3i4rB:
undetectable		 3bgdA-3i4rB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 7 ASP B1124
LEU B1071
GLN B1079
LEU B1078
 None
 0.90A 4ib4A-3i4rB:
undetectable		 4ib4A-3i4rB:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_STRA301_1
(ANCESTRAL STEROID
RECEPTOR 2)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		5 / 12 LEU B 970
LEU B 973
LEU B 976
ALA B 977
LEU B 938
 None
 0.81A 4ltwA-3i4rB:
undetectable		 4ltwA-3i4rB:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 LYS B1049
ASN B1040
ASP B1053
 None
 0.70A 4o1eA-3i4rB:
undetectable		 4o1eA-3i4rB:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA307_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 4 LEU B 956
LEU B 953
SER B 936
ALA B 949
 None
 1.04A 5uunA-3i4rB:
1.7		 5uunA-3i4rB:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_A_ADNA503_1
(ADENOSYLHOMOCYSTEINA
SE)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 LEU B1119
GLN B1155
LYS B1097
 None
 0.93A 6exiB-3i4rB:
undetectable		 6exiB-3i4rB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_B_ADNB503_0
(ADENOSYLHOMOCYSTEINA
SE)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		3 / 3 LEU B1119
GLN B1155
LYS B1097
 None
 0.90A 6exiA-3i4rB:
undetectable		 6exiA-3i4rB:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3i4r NUCLEAR PORE COMPLEX
PROTEIN NUP133
(Homo
sapiens) 		4 / 4 ASP B1053
ILE B1032
PRO B1029
LEU B1054
 None
 1.26A 6mkeA-3i4rB:
undetectable		 6mkeA-3i4rB:
7.33