SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA8_0
(GRAMICIDIN A)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		3 / 3 VAL A 128
TRP A  70
TRP A 145
 None
 1.08A 1c4dA-3i4sA:
undetectable
1c4dB-3i4sA:
undetectable		 1c4dA-3i4sA:
6.34
1c4dB-3i4sA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_A_BAXA1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		4 / 6 VAL A 144
VAL A 101
ILE A 108
ILE A 169
 None
 0.69A 1uwhA-3i4sA:
3.0		 1uwhA-3i4sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		4 / 6 VAL A 144
VAL A 101
ILE A 108
ILE A 169
 None
 0.70A 1uwhB-3i4sA:
3.0		 1uwhB-3i4sA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		4 / 4 LEU A 105
PRO A 143
ILE A 116
LEU A 114
 None
 1.07A 1ya4C-3i4sA:
undetectable		 1ya4C-3i4sA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJ1_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 ILE A 130
GLU A 107
THR A 109
ILE A 108
LEU A 165
 None
 1.01A 4ej1B-3i4sA:
undetectable		 4ej1B-3i4sA:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TVT_A_ASCA303_0
(THAUMATIN-1)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		4 / 7 LEU A  55
GLU A  97
SER A  58
VAL A 128
 None
 1.21A 4tvtA-3i4sA:
undetectable		 4tvtA-3i4sA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CA1_B_MIGB701_1
(GLYCOSYL HYDROLASE,
FAMILY 31)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		5 / 12 TRP A  70
ILE A  63
ASP A  48
ARG A  44
HIS A 127
 None
 1.44A 6ca1B-3i4sA:
undetectable		 6ca1B-3i4sA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_B_AQ4B602_1
(CYTOCHROME P450 1A1)		 3i4s HISTIDINE TRIAD
PROTEIN
(Bradyrhizobium
japonicum) 		4 / 7 ASN A 115
ALA A 104
VAL A  60
LEU A  71
 None
 0.63A 6dwnB-3i4sA:
undetectable		 6dwnB-3i4sA:
21.23