SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 6 VAL A 208
VAL A 131
ILE A 151
ASN A 152
 None
 0.88A 1e06A-3i4tA:
undetectable		 1e06A-3i4tA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_F_BEZF5023_0
(CES1 PROTEIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 6 LEU A 124
GLY A 118
LEU A 249
ILE A 113
 None
 0.79A 1yajF-3i4tA:
undetectable		 1yajF-3i4tA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFS_A_J01A500_1
(ORF12)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 8 VAL A  85
ARG A  18
GLY A  19
ALA A  22
 None
 0.80A 2xfsA-3i4tA:
undetectable		 2xfsA-3i4tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XH9_A_J01A1436_1
(ORF12)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 8 VAL A  85
ARG A  18
GLY A  19
ALA A  22
 None
 0.81A 2xh9A-3i4tA:
undetectable		 2xh9A-3i4tA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_B_LEIB16_0
(COIL SER L16D-PEN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 5 LEU A 237
GLN A 196
LEU A 198
GLU A 195
 None
 1.12A 3h5gA-3i4tA:
undetectable
3h5gB-3i4tA:
undetectable		 3h5gA-3i4tA:
6.94
3h5gB-3i4tA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_A_PFLA319_1
(GLR4197 PROTEIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 7 ILE A   5
LEU A  80
THR A  16
ILE A  15
 None
 0.76A 3p50A-3i4tA:
undetectable		 3p50A-3i4tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_B_PFLB319_1
(GLR4197 PROTEIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 7 ILE A   5
LEU A  80
THR A  16
ILE A  15
 None
 0.76A 3p50B-3i4tA:
undetectable		 3p50B-3i4tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_C_PFLC319_1
(GLR4197 PROTEIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 7 ILE A   5
LEU A  80
THR A  16
ILE A  15
 None
 0.78A 3p50C-3i4tA:
undetectable		 3p50C-3i4tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_D_PFLD320_1
(GLR4197 PROTEIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 7 ILE A   5
LEU A  80
THR A  16
ILE A  15
 None
 0.77A 3p50D-3i4tA:
undetectable		 3p50D-3i4tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P50_E_PFLE319_1
(GLR4197 PROTEIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 7 ILE A   5
LEU A  80
THR A  16
ILE A  15
 None
 0.79A 3p50E-3i4tA:
undetectable		 3p50E-3i4tA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		3 / 3 MET A 214
MET A 218
TYR A 268
 None
 1.11A 4p6xI-3i4tA:
undetectable		 4p6xI-3i4tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		4 / 4 GLY A  83
LEU A 160
PHE A 127
ILE A 117
 None
 0.78A 4xv2A-3i4tA:
undetectable		 4xv2A-3i4tA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0R_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A  80
LEU A   7
ILE A   5
LYS A 106
ILE A 108
 None
 0.65A 4y0rA-3i4tA:
undetectable		 4y0rA-3i4tA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H1E_A_VDXA501_1
(VITAMIN D3 RECEPTOR)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 PHE A 127
LEU A 249
SER A 120
ILE A 228
HIS A 246
 None
 1.49A 5h1eA-3i4tA:
undetectable		 5h1eA-3i4tA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 MET A 188
LEU A 236
MET A 233
LEU A 237
LEU A 198
 None
 1.15A 5toaB-3i4tA:
undetectable		 5toaB-3i4tA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_B_GMJB301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 LEU A  80
PHE A  95
HIS A 109
THR A  16
LEU A  20
 None
 1.35A 6djzB-3i4tA:
undetectable		 6djzB-3i4tA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 3i4t DIPHTHINE SYNTHASE
(Entamoeba
histolytica) 		5 / 12 ILE A   5
GLY A   6
GLY A  83
ALA A  88
ASP A  14
 None
 0.82A 6iftA-3i4tA:
undetectable		 6iftA-3i4tA:
23.51