SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 3i4u ATP-DEPENDENT RNA
HELICASE DHX8
(Homo
sapiens) 		3 / 3 PHE A1035
ARG A1079
ASN A1050
 None
GOL  A  11 (-4.0A)
None
 0.78A 1xzxX-3i4uA:
undetectable		 1xzxX-3i4uA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 3i4u ATP-DEPENDENT RNA
HELICASE DHX8
(Homo
sapiens) 		5 / 9 ARG A 979
LEU A1006
ARG A1088
GLU A 982
GLY A1084
 BR  A   1 (-4.1A)
None
GOL  A  12 (-4.0A)
None
GOL  A  13 ( 3.3A)
 1.38A 3nxuB-3i4uA:
undetectable		 3nxuB-3i4uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 3i4u ATP-DEPENDENT RNA
HELICASE DHX8
(Homo
sapiens) 		5 / 12 PHE A1180
PRO A 987
GLN A 960
THR A 963
LEU A 964
 None
 1.45A 4ac0A-3i4uA:
undetectable		 4ac0A-3i4uA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB307_1
(CHITOSANASE)		 3i4u ATP-DEPENDENT RNA
HELICASE DHX8
(Homo
sapiens) 		4 / 7 ARG A 975
THR A 974
GLY A 977
HIS A 998
 BR  A   1 (-4.5A)
None
None
BR  A   1 (-4.2A)
 0.73A 4qwpB-3i4uA:
undetectable		 4qwpB-3i4uA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_2
(TUBULIN BETA CHAIN)		 3i4u ATP-DEPENDENT RNA
HELICASE DHX8
(Homo
sapiens) 		5 / 12 CYH A1108
LEU A1173
VAL A1150
LYS A1117
ALA A1115
 None
 1.17A 4x1kD-3i4uA:
undetectable		 4x1kD-3i4uA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE0_A_XINA401_2
(AP2-ASSOCIATED
PROTEIN KINASE 1)		 3i4u ATP-DEPENDENT RNA
HELICASE DHX8
(Homo
sapiens) 		4 / 5 LEU A1006
VAL A1009
MET A 992
CYH A1001
 None
 1.37A 5te0A-3i4uA:
undetectable		 5te0A-3i4uA:
22.07