SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i4x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I2W_A_CFXA1300_2
(BETA-LACTAMASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 TYR A 310
PRO A 313
LEU A 315
THR A 347
 None
None
GOL  A 462 ( 4.4A)
None
 1.36A 1i2wA-3i4xA:
undetectable		 1i2wA-3i4xA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHR_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		5 / 9 THR A 240
GLY A 306
LEU A 307
SER A 268
GLU A 264
 None
 1.18A 1jhrA-3i4xA:
undetectable		 1jhrA-3i4xA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5M_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		5 / 9 THR A 240
GLY A 306
LEU A 307
SER A 268
GLU A 264
 None
 1.15A 1l5mA-3i4xA:
undetectable		 1l5mA-3i4xA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 6 LEU A 395
ALA A 357
HIS A 389
ASP A 388
 None
 1.23A 2dpzA-3i4xA:
undetectable		 2dpzA-3i4xA:
13.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 7 THR A  86
PRO A  87
GLU A 418
PRO A  70
 None
 0.96A 2v2gA-3i4xA:
undetectable
2v2gB-3i4xA:
undetectable		 2v2gA-3i4xA:
17.97
2v2gB-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 7 PRO A  70
THR A  86
PRO A  87
GLU A 418
 None
 0.94A 2v2gA-3i4xA:
undetectable
2v2gB-3i4xA:
undetectable		 2v2gA-3i4xA:
17.97
2v2gB-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 7 THR A  86
PRO A  87
GLU A 418
PRO A  70
 None
 0.97A 2v2gC-3i4xA:
undetectable
2v2gD-3i4xA:
undetectable		 2v2gC-3i4xA:
17.97
2v2gD-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V2G_D_BEZD1221_0
(PEROXIREDOXIN 6)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 7 PRO A  70
THR A  86
PRO A  87
GLU A 418
 None
 0.91A 2v2gC-3i4xA:
undetectable
2v2gD-3i4xA:
undetectable		 2v2gC-3i4xA:
17.97
2v2gD-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 THR A  86
PRO A  87
GLU A 418
PRO A  70
 None
 0.95A 2v32A-3i4xA:
undetectable
2v32B-3i4xA:
undetectable		 2v32A-3i4xA:
17.97
2v32B-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_B_BEZB1220_0
(PEROXIREDOXIN 6)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 PRO A  70
THR A  86
PRO A  87
GLU A 418
 None
 0.97A 2v32A-3i4xA:
undetectable
2v32B-3i4xA:
undetectable		 2v32A-3i4xA:
17.97
2v32B-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_C_BEZC1222_0
(PEROXIREDOXIN 6)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 THR A  86
PRO A  87
GLU A 418
PRO A  70
 None
 1.00A 2v32C-3i4xA:
undetectable
2v32D-3i4xA:
undetectable		 2v32C-3i4xA:
17.97
2v32D-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_C_BEZC1218_0
(PEROXIREDOXIN 6.)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 THR A  86
PRO A  87
GLU A 418
PRO A  70
 None
 0.91A 2v41C-3i4xA:
undetectable
2v41D-3i4xA:
undetectable		 2v41C-3i4xA:
17.97
2v41D-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_D_BEZD1222_0
(PEROXIREDOXIN 6.)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 PRO A  70
THR A  86
PRO A  87
GLU A 418
 None
 0.98A 2v41C-3i4xA:
undetectable
2v41D-3i4xA:
undetectable		 2v41C-3i4xA:
17.97
2v41D-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 7 THR A  86
PRO A  87
GLU A 418
PRO A  70
 None
 0.90A 2v41E-3i4xA:
undetectable
2v41F-3i4xA:
undetectable		 2v41E-3i4xA:
17.97
2v41F-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_F_BEZF1222_0
(PEROXIREDOXIN 6.)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 7 PRO A  70
THR A  86
PRO A  87
GLU A 418
 None
 0.96A 2v41E-3i4xA:
undetectable
2v41F-3i4xA:
undetectable		 2v41E-3i4xA:
17.97
2v41F-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_G_BEZG1222_0
(PEROXIREDOXIN 6.)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 THR A  86
PRO A  87
GLU A 418
PRO A  70
 None
 1.02A 2v41G-3i4xA:
undetectable
2v41H-3i4xA:
undetectable		 2v41G-3i4xA:
17.97
2v41H-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_H_BEZH1222_0
(PEROXIREDOXIN 6.)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 PRO A  70
THR A  86
PRO A  87
GLU A 418
 None
 0.94A 2v41G-3i4xA:
undetectable
2v41H-3i4xA:
undetectable		 2v41G-3i4xA:
17.97
2v41H-3i4xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 TYR A  58
PHE A  88
LEU A 179
VAL A  99
 None
 0.90A 2w98B-3i4xA:
undetectable		 2w98B-3i4xA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZJ0_A_2FAA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.20A 2zj0A-3i4xA:
undetectable		 2zj0A-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		5 / 12 CYH A 248
SER A 256
LEU A 214
LEU A 148
PHE A 141
 None
 1.34A 3adsA-3i4xA:
undetectable		 3adsA-3i4xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADX_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		5 / 12 CYH A 248
SER A 256
LEU A 214
LEU A 148
PHE A 141
 None
 1.35A 3adxA-3i4xA:
undetectable		 3adxA-3i4xA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APW_A_DP0A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		5 / 12 TYR A  46
PHE A  37
TYR A 101
VAL A  99
ILE A  98
 None
 1.29A 3apwA-3i4xA:
undetectable		 3apwA-3i4xA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 VAL A 211
GLN A 335
PHE A 141
ARG A 220
 None
 1.30A 3bjwE-3i4xA:
undetectable		 3bjwE-3i4xA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC505_2
(PHOSPHOLIPASE A2)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 VAL A 211
GLN A 335
PHE A 141
ARG A 220
 None
 1.33A 3bjwH-3i4xA:
undetectable		 3bjwH-3i4xA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 VAL A 211
GLN A 335
PHE A 141
ARG A 220
 None
 1.22A 3bjwB-3i4xA:
undetectable		 3bjwB-3i4xA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.23A 3ce6A-3i4xA:
undetectable		 3ce6A-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_2
(ADENOSYLHOMOCYSTEINA
SE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.21A 3ce6C-3i4xA:
undetectable		 3ce6C-3i4xA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		3 / 3 SER A 416
GLN A 415
PHE A 417
 None
 0.77A 3g4lC-3i4xA:
undetectable		 3g4lC-3i4xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 LEU A 206
SER A 210
ARG A 213
LEU A 148
 None
 1.11A 3onnA-3i4xA:
undetectable		 3onnA-3i4xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 TYR A 394
SER A 416
ASP A 353
ASP A 390
 None
 1.27A 3uj7B-3i4xA:
undetectable		 3uj7B-3i4xA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HFP_B_15UB402_1
(PROTHROMBIN)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		5 / 12 HIS A 389
TYR A 384
LEU A 392
ALA A 423
ILE A 320
 None
 1.27A 4hfpB-3i4xA:
undetectable		 4hfpB-3i4xA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.34A 4lvcA-3i4xA:
undetectable		 4lvcA-3i4xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEO_A_VDYA206_2
(CDL2.3A)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 8 ILE A 232
PRO A 243
LEU A 333
ILE A 258
 None
 0.84A 5ieoA-3i4xA:
0.4		 5ieoA-3i4xA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_A_8NUA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		5 / 12 SER A 416
THR A  57
ILE A  56
LEU A  92
PHE A  19
 None
 1.36A 6a93A-3i4xA:
undetectable		 6a93A-3i4xA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.35A 6gbnA-3i4xA:
undetectable		 6gbnA-3i4xA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		4 / 5 GLN A 343
THR A 348
HIS A 396
LEU A 360
 DST  A 460 (-3.1A)
None
None
None
 1.36A 6gbnD-3i4xA:
undetectable		 6gbnD-3i4xA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNA_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		3 / 3 ARG A 100
LYS A 180
TYR A  46
 DST  A 460 (-3.0A)
None
None
 1.37A 6gnaA-3i4xA:
undetectable		 6gnaA-3i4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNB_A_ACTA307_0
(THIOREDOXIN
REDUCTASE)		 3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE
(Aspergillus
fumigatus) 		3 / 3 ARG A 100
LYS A 180
TYR A  46
 DST  A 460 (-3.0A)
None
None
 1.37A 6gnbA-3i4xA:
undetectable		 6gnbA-3i4xA:
21.81