SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i50'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1121_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB
(Mus
musculus) 		4 / 5 VAL H 166
SER H 176
VAL H 169
SER H 178
 None
 1.17A 2j9cA-3i50H:
undetectable
2j9cB-3i50H:
undetectable
2j9cC-3i50H:
undetectable		 2j9cA-3i50H:
18.05
2j9cB-3i50H:
18.05
2j9cC-3i50H:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB2_A_IBPA3960_1
(LACTOTRANSFERRIN)		 3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB
(Mus
musculus) 		4 / 4 GLY H  10
VAL H 109
GLY H  16
THR H  82
 None
 0.93A 3ib2A-3i50H:
undetectable		 3ib2A-3i50H:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAV_A_RAVA183_1
(FERRITIN LIGHT CHAIN)		 3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB
(Mus
musculus) 		4 / 6 LEU H  48
SER H  60
TYR H  59
ALA H  61
 None
 1.02A 3ravA-3i50H:
undetectable		 3ravA-3i50H:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_B_CQAB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB
(Mus
musculus) 		4 / 8 GLU H  46
GLU H  85
ARG H  87
GLY H  42
 None
 0.95A 4fgzA-3i50H:
undetectable
4fgzB-3i50H:
undetectable		 4fgzA-3i50H:
22.34
4fgzB-3i50H:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB
(Mus
musculus) 		4 / 5 THR H  82
GLY H  16
VAL H  12
PRO H  14
 None
 1.00A 4grkA-3i50H:
undetectable		 4grkA-3i50H:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_C_EPAC502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 3i50 MURINE HEAVY CHAIN
(IGG3) OF E53
MONOCLONAL ANTIBODY
FAB
(Mus
musculus) 		4 / 8 LEU H  48
PHE H  67
PRO H  40
ALA H  88
 None
 0.97A 5m0oC-3i50H:
undetectable		 5m0oC-3i50H:
19.67