SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i58'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FPQ_A_SAMA1699_0
(ISOLIQUIRITIGENIN
2'-O-METHYLTRANSFERA
SE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 10 GLY A 177
ASP A 200
LEU A 201
ALA A 243
TRP A 248
 SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
None
 0.21A 1fpqA-3i58A:
19.9		 1fpqA-3i58A:
27.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_ACTA421_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 8 ASP A 175
GLY A 178
GLY A 181
GLY A 182
LEU A 184
SER A 242
 SAH  A 401 ( 4.2A)
SAH  A 401 (-3.6A)
None
None
None
SAH  A 401 (-2.8A)
 0.68A 1qzzA-3i58A:
35.2		 1qzzA-3i58A:
43.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		7 / 12 GLY A 177
GLY A 178
GLY A 179
LEU A 201
PRO A 204
PHE A 228
TRP A 248
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.4A)
None
 0.32A 1qzzA-3i58A:
35.2		 1qzzA-3i58A:
43.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		7 / 12 TRP A 133
GLY A 177
GLY A 178
LEU A 201
PRO A 204
PHE A 228
TRP A 248
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.4A)
None
 0.74A 1qzzA-3i58A:
35.2		 1qzzA-3i58A:
43.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 TRP A 133
GLY A 179
LEU A 201
PHE A 228
TRP A 248
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.4A)
None
 1.15A 1qzzA-3i58A:
35.2		 1qzzA-3i58A:
43.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 TYR A 158
GLY A 177
GLY A 178
LEU A 201
PHE A 228
TRP A 248
 None
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.4A)
None
 1.16A 1qzzA-3i58A:
35.2		 1qzzA-3i58A:
43.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 ALA A 190
ALA A 162
LEU A 183
ILE A 326
LEU A 271
 None
 1.13A 1rg7A-3i58A:
undetectable		 1rg7A-3i58A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV9_A_DIFA701_1
(PHOSPHOLIPASE A2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 8 LEU A 154
ALA A 243
ILE A 273
GLY A 178
 SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
None
SAH  A 401 (-3.6A)
 0.83A 1sv9A-3i58A:
undetectable		 1sv9A-3i58A:
16.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		9 / 12 TRP A 133
GLY A 177
GLY A 178
GLY A 179
LEU A 201
PRO A 204
PHE A 228
SER A 242
TRP A 248
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.8A)
None
 0.28A 1xdsA-3i58A:
31.3		 1xdsA-3i58A:
43.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		9 / 12 TRP A 133
GLY A 177
GLY A 178
GLY A 179
LEU A 201
PRO A 204
PHE A 228
SER A 242
TRP A 248
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.8A)
None
 0.49A 1xdsB-3i58A:
30.9		 1xdsB-3i58A:
43.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1XDS_B_SAMB9635_0
(PROTEIN RDMB)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 TRP A 133
GLY A 179
LEU A 201
PHE A 228
TRP A 248
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.4A)
None
 1.01A 1xdsB-3i58A:
30.9		 1xdsB-3i58A:
43.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 6 GLY A 219
PHE A 212
SER A 218
ARG A 220
 GOL  A 403 (-4.4A)
None
None
None
 1.33A 2a3cA-3i58A:
undetectable		 2a3cA-3i58A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 11 LEU A 241
VAL A 327
GLY A 305
VAL A 270
VAL A 272
 None
 0.95A 2nnpB-3i58A:
undetectable		 2nnpB-3i58A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 GLY A 106
ARG A 105
TYR A 293
 None
None
7NA  A 402 ( 4.5A)
 0.78A 2opxA-3i58A:
4.5		 2opxA-3i58A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_B_SAMB300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
GLY A 181
LEU A 201
VAL A 244
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.5A)
 0.78A 2oxtB-3i58A:
7.1		 2oxtB-3i58A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_C_SAMC300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
GLY A 182
LEU A 201
VAL A 244
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.5A)
 0.85A 2oxtC-3i58A:
5.7		 2oxtC-3i58A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OXT_D_SAMD300_0
(NUCLEOSIDE-2'-O-METH
YLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 ASP A 175
GLY A 177
GLY A 179
GLY A 182
LEU A 201
VAL A 244
 SAH  A 401 ( 4.2A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
None
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.5A)
 0.83A 2oxtD-3i58A:
7.2		 2oxtD-3i58A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 7 TRP A 133
GLY A 106
GLY A 296
PHE A 146
 SAH  A 401 (-3.8A)
None
None
None
 0.92A 2qwxA-3i58A:
undetectable
2qwxB-3i58A:
undetectable		 2qwxA-3i58A:
22.90
2qwxB-3i58A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 6 LEU A 183
LEU A 184
ASP A 175
ILE A 273
 None
None
SAH  A 401 ( 4.2A)
None
 0.74A 2rlfA-3i58A:
undetectable
2rlfB-3i58A:
undetectable		 2rlfA-3i58A:
9.52
2rlfB-3i58A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 6 LEU A 183
LEU A 184
ASP A 175
ILE A 273
 None
None
SAH  A 401 ( 4.2A)
None
 0.75A 2rlfB-3i58A:
undetectable
2rlfC-3i58A:
undetectable		 2rlfB-3i58A:
9.52
2rlfC-3i58A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 6 LEU A 183
LEU A 184
ASP A 175
ILE A 273
 None
None
SAH  A 401 ( 4.2A)
None
 0.95A 2rlfC-3i58A:
undetectable
2rlfD-3i58A:
undetectable		 2rlfC-3i58A:
9.52
2rlfD-3i58A:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_A_SAMA601_0
(HYPOTHETICAL PROTEIN)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
SER A 180
LEU A 183
VAL A 244
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
None
None
SAH  A 401 ( 4.5A)
 0.68A 2yvlA-3i58A:
11.9		 2yvlA-3i58A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYW_A_017A201_1
(HIV-1 PROTEASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A  37
ASP A  32
VAL A  30
GLY A  77
ILE A  44
 None
 0.96A 3cywA-3i58A:
undetectable		 3cywA-3i58A:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_0
(PCZA361.24)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 179
LEU A 183
LEU A 199
LEU A 201
SER A 242
 SAH  A 401 (-3.6A)
None
None
SAH  A 401 (-4.4A)
SAH  A 401 (-2.8A)
 0.94A 3g2oA-3i58A:
15.1		 3g2oA-3i58A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_B_SAMB600_0
(PCZA361.24)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 179
LEU A 183
LEU A 199
LEU A 201
SER A 242
 SAH  A 401 (-3.6A)
None
None
SAH  A 401 (-4.4A)
SAH  A 401 (-2.8A)
 0.85A 3g2oB-3i58A:
15.5		 3g2oB-3i58A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 108
LEU A 142
ASP A 139
ASP A 135
THR A 130
 None
 1.04A 3gwuA-3i58A:
undetectable		 3gwuA-3i58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 108
LEU A 142
ASP A 139
ASP A 135
THR A 130
 None
 1.15A 3gwuA-3i58A:
undetectable		 3gwuA-3i58A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWV_A_RFXA801_1
(TRANSPORTER)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 109
LEU A 108
LEU A 142
ASP A 139
ASP A 135
 None
 1.03A 3gwvA-3i58A:
undetectable		 3gwvA-3i58A:
23.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		7 / 12 PHE A 146
MET A 150
HIS A 153
GLY A 177
LEU A 201
PRO A 204
ALA A 243
 None
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
 0.96A 3i5uA-3i58A:
49.7		 3i5uA-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		12 / 12 TRP A 133
PHE A 146
MET A 150
HIS A 153
LEU A 154
GLY A 178
GLY A 179
LEU A 201
PRO A 204
ALA A 243
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
None
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
SAH  A 401 (-4.6A)
None
 0.21A 3i5uA-3i58A:
49.7		 3i5uA-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_A_SAMA401_1
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 4 ASP A 200
SER A 227
PHE A 228
SER A 242
 SAH  A 401 (-2.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.8A)
 0.14A 3i5uA-3i58A:
49.7		 3i5uA-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 MET A 150
HIS A 153
GLY A 177
GLY A 178
LEU A 201
ALA A 243
 7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
 1.28A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 MET A 150
HIS A 153
GLY A 177
LEU A 201
PRO A 204
ALA A 243
 7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
7NA  A 402 ( 3.7A)
 1.02A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		12 / 12 TRP A 133
MET A 150
HIS A 153
LEU A 154
GLY A 178
GLY A 179
LEU A 201
PRO A 204
SER A 227
ALA A 243
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.3A)
7NA  A 402 ( 3.7A)
SAH  A 401 (-4.6A)
None
 0.20A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		10 / 12 TRP A 133
MET A 150
HIS A 153
LEU A 154
GLY A 178
LEU A 201
SER A 227
ALA A 243
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
7NA  A 402 ( 3.6A)
7NA  A 402 (-4.1A)
SAH  A 401 ( 4.7A)
SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.3A)
7NA  A 402 ( 3.7A)
SAH  A 401 (-4.6A)
None
 0.91A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 ASP A 200
PHE A 228
SER A 242
 SAH  A 401 (-2.8A)
SAH  A 401 (-3.4A)
SAH  A 401 (-2.8A)
 0.05A 3i5uB-3i58A:
49.4		 3i5uB-3i58A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_A_NCAA1163_0
(TANKYRASE-2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 8 GLY A 120
ALA A 123
SER A 116
GLU A 112
 None
 0.88A 3u9hA-3i58A:
undetectable		 3u9hA-3i58A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9H_B_NCAB1164_0
(TANKYRASE-2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 8 GLY A 120
ALA A 123
SER A 116
GLU A 112
 None
 0.82A 3u9hB-3i58A:
undetectable		 3u9hB-3i58A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.69A 4a6eA-3i58A:
29.4		 4a6eA-3i58A:
27.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 8 VAL A 327
TYR A 165
VAL A 276
ILE A 273
 None
 1.14A 4aftD-3i58A:
undetectable
4aftE-3i58A:
undetectable		 4aftD-3i58A:
22.30
4aftE-3i58A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BJC_A_RPBA2162_1
(TANKYRASE-2)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 8 GLY A 120
ALA A 123
SER A 116
GLU A 112
 None
 0.83A 4bjcA-3i58A:
undetectable		 4bjcA-3i58A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 PHE A 229
ILE A 256
LEU A 232
PHE A 228
ALA A 264
 SAH  A 401 ( 4.8A)
None
None
SAH  A 401 (-3.4A)
None
 1.19A 4eb4A-3i58A:
undetectable		 4eb4A-3i58A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 PHE A 229
ILE A 256
LEU A 232
PHE A 228
ALA A 264
 SAH  A 401 ( 4.8A)
None
None
SAH  A 401 (-3.4A)
None
 1.20A 4eb4B-3i58A:
undetectable		 4eb4B-3i58A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_A_SAMA301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
ASP A 200
LEU A 201
ALA A 243
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
 1.11A 4lg1A-3i58A:
12.6		 4lg1A-3i58A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
GLY A 179
ASP A 200
LEU A 201
ALA A 243
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
7NA  A 402 ( 3.7A)
 1.13A 4lg1C-3i58A:
12.4		 4lg1C-3i58A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M48_A_21BA704_1
(TRANSPORTER)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 8 ASP A 147
ASP A 175
SER A 180
GLY A 182
ALA A 243
 None
SAH  A 401 ( 4.2A)
None
None
7NA  A 402 ( 3.7A)
 1.40A 4m48A-3i58A:
undetectable		 4m48A-3i58A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 ASP A 247
VAL A 244
LEU A 201
GLY A 179
ASP A 147
 SAH  A 401 (-4.6A)
SAH  A 401 ( 4.5A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.6A)
None
 1.37A 4pevC-3i58A:
2.5		 4pevC-3i58A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 ASP A 175
GLY A 177
ASP A 200
LEU A 201
ASP A 247
TRP A 248
 SAH  A 401 ( 4.2A)
SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
SAH  A 401 (-4.6A)
None
 0.52A 4pghB-3i58A:
8.3		 4pghB-3i58A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 GLY A 177
GLY A 178
ASP A 200
LEU A 201
PHE A 229
TRP A 248
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
SAH  A 401 ( 4.8A)
None
 0.57A 4pghD-3i58A:
21.9		 4pghD-3i58A:
29.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		4 / 5 ASP A 147
VAL A 198
ASP A 175
GLY A 177
 None
None
SAH  A 401 ( 4.2A)
SAH  A 401 (-3.9A)
 1.16A 4xp6A-3i58A:
undetectable		 4xp6A-3i58A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLU A 306
GLY A 305
LEU A 313
VAL A 327
VAL A 272
 None
 1.11A 5dpdA-3i58A:
14.0		 5dpdA-3i58A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 177
ASP A 200
LEU A 201
SER A 227
VAL A 244
 SAH  A 401 (-3.9A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.3A)
SAH  A 401 ( 4.5A)
 0.85A 5dpdB-3i58A:
14.0		 5dpdB-3i58A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 THR A 130
SER A 131
TYR A 124
 None
 0.59A 5jsdA-3i58A:
undetectable		 5jsdA-3i58A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 THR A 130
SER A 131
TYR A 124
 None
 0.59A 5jsdB-3i58A:
undetectable		 5jsdB-3i58A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 THR A 130
SER A 131
TYR A 124
 None
 0.58A 5jsdC-3i58A:
undetectable		 5jsdC-3i58A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 THR A 130
SER A 131
TYR A 124
 None
 0.59A 5jseA-3i58A:
undetectable		 5jseA-3i58A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 THR A 130
SER A 131
TYR A 124
 None
 0.59A 5jseB-3i58A:
undetectable		 5jseB-3i58A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		3 / 3 THR A 130
SER A 131
TYR A 124
 None
 0.59A 5jseC-3i58A:
undetectable		 5jseC-3i58A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 305
VAL A 270
VAL A 254
ALA A 253
LEU A 257
 None
 1.06A 5kocA-3i58A:
11.6		 5kocA-3i58A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLU A 303
THR A 119
ARG A 299
GLY A 296
LEU A 291
 None
 1.30A 5m50E-3i58A:
2.8		 5m50E-3i58A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 LEU A 187
VAL A 240
SER A 242
VAL A 324
TYR A 323
 None
None
SAH  A 401 (-2.8A)
None
None
 1.32A 5v1tA-3i58A:
undetectable		 5v1tA-3i58A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 178
LEU A 201
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.46A 5w7pA-3i58A:
28.4		 5w7pA-3i58A:
25.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_0
(OXAC)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 12 GLY A 179
LEU A 201
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.6A)
SAH  A 401 (-4.4A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.91A 5w7pA-3i58A:
28.4		 5w7pA-3i58A:
25.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		7 / 12 TRP A 133
ASP A 147
GLY A 177
GLY A 179
SER A 227
PHE A 228
ASP A 247
 SAH  A 401 (-3.8A)
None
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
 0.72A 6clxA-3i58A:
32.3		 6clxA-3i58A:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		7 / 12 TRP A 133
GLY A 177
GLY A 179
SER A 227
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.51A 6clxA-3i58A:
32.3		 6clxA-3i58A:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 12 TRP A 133
GLY A 178
SER A 227
PHE A 228
ASP A 247
TRP A 248
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
None
 0.69A 6clxA-3i58A:
32.3		 6clxA-3i58A:
39.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6CLX_B_SAMB401_0
(O-METHYLTRANSFERASE)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		6 / 10 TRP A 133
GLY A 178
ASP A 200
SER A 227
PHE A 228
ASP A 247
 SAH  A 401 (-3.8A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 (-3.3A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
 0.82A 6clxB-3i58A:
22.4		 6clxB-3i58A:
39.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I5Z_D_SAMD401_0
(O-METHYLTRANSFERASE
1)		 3i58 O-METHYLTRANSFERASE
(Streptomyces
carzinostaticus) 		5 / 11 GLY A 177
GLY A 179
ASP A 200
LEU A 201
ASP A 247
 SAH  A 401 (-3.9A)
SAH  A 401 (-3.6A)
SAH  A 401 (-2.8A)
SAH  A 401 (-4.4A)
SAH  A 401 (-4.6A)
 0.36A 6i5zD-3i58A:
23.6		 6i5zD-3i58A:
26.60