SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i5a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 11 ALA A 233
LEU A 257
LEU A 204
SER A 275
LEU A 272
 None
C2E  A 335 ( 3.6A)
None
None
None
 0.97A 2ceoA-3i5aA:
undetectable		 2ceoA-3i5aA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_B_T44B1395_1
(THYROXINE-BINDING
GLOBULIN)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		5 / 10 ALA A 233
LEU A 257
LEU A 204
SER A 275
LEU A 272
 None
C2E  A 335 ( 3.6A)
None
None
None
 0.98A 2ceoB-3i5aA:
undetectable		 2ceoB-3i5aA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 8 ARG A 180
GLY A 249
ARG A 247
THR A 175
 None
 0.90A 2f9wA-3i5aA:
undetectable
2f9wB-3i5aA:
undetectable		 2f9wA-3i5aA:
24.09
2f9wB-3i5aA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_B_ASWB1301_1
(DNA TOPOISOMERASE
2-BETA)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 7 ILE A 206
GLY A 334
ALA A 269
GLN A 311
 None
 0.90A 4g0uB-3i5aA:
3.3		 4g0uB-3i5aA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		3 / 3 LYS A 324
LEU A 320
ALA A 323
 None
 0.65A 4ikiA-3i5aA:
undetectable		 4ikiA-3i5aA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 ARG A 132
ILE A 131
GLY A  35
ILE A  42
 None
 0.76A 5dzki-3i5aA:
undetectable
5dzkj-3i5aA:
undetectable
5dzkx-3i5aA:
undetectable		 5dzki-3i5aA:
20.85
5dzkj-3i5aA:
20.85
5dzkx-3i5aA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 4 LEU A 292
LEU A 227
GLY A 223
GLU A 222
 None
 1.13A 5hhjA-3i5aA:
4.8		 5hhjA-3i5aA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 3i5a RESPONSE
REGULATOR/GGDEF
DOMAIN PROTEIN
(Pseudomonas
syringae
group
genomosp.
3) 		4 / 5 GLY A  76
LEU A  74
TYR A  83
GLN A  67
 None
 1.31A 6ji6A-3i5aA:
undetectable		 6ji6A-3i5aA:
19.82