SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i5b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ASP A 226
LEU A 179
GLY A 225
ASN A 217
THR A 177
 None
 1.14A 1likA-3i5bA:
undetectable		 1likA-3i5bA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_B_SAMB501_0
(BIOTIN SYNTHASE)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ASN A 217
HIS A 222
ILE A 283
LEU A 281
VAL A 278
 None
 1.21A 1r30B-3i5bA:
undetectable		 1r30B-3i5bA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.78A 2hs1B-3i5bA:
undetectable		 2hs1B-3i5bA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 303
LEU A 206
MET A 207
 None
 0.84A 2itzA-3i5bA:
undetectable		 2itzA-3i5bA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 7 ASP A 320
GLN A 321
TYR A 324
GLU A 254
 None
 1.14A 3l2vA-3i5bA:
undetectable		 3l2vA-3i5bA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 4 LEU A 315
LEU A 259
GLN A 321
GLU A 254
 None
 1.26A 4i41A-3i5bA:
undetectable		 4i41A-3i5bA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 327
LEU A 323
ALA A 326
 TLA  A   2 (-2.8A)
None
None
 0.81A 4iizA-3i5bA:
undetectable		 4iizA-3i5bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKI_A_IMNA201_1
(TRANSTHYRETIN)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 327
LEU A 323
ALA A 326
 TLA  A   2 (-2.8A)
None
None
 0.70A 4ikiA-3i5bA:
undetectable		 4ikiA-3i5bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.66A 4q1xB-3i5bA:
undetectable		 4q1xB-3i5bA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.75A 4q1yB-3i5bA:
undetectable		 4q1yB-3i5bA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 PHE A 185
ILE A 316
ALA A 256
SER A 301
LEU A 315
 None
 1.28A 4qztC-3i5bA:
undetectable		 4qztC-3i5bA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		4 / 4 GLY A 299
LEU A 189
PHE A 312
ILE A 316
 None
 0.95A 4xv2A-3i5bA:
1.7		 4xv2A-3i5bA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZBD_A_TRPA501_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 ARG A 313
TYR A 250
ALA A 248
LEU A 205
VAL A 258
 None
 1.45A 5zbdA-3i5bA:
undetectable		 5zbdA-3i5bA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6I_A_8PRA509_1
(ENVELOPE
GLYCOPROTEIN,GP,GP1
ENVELOPE
GLYCOPROTEIN)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 12 ARG A 249
VAL A 232
LEU A 281
ALA A 233
GLY A 234
 None
 1.16A 6f6iA-3i5bA:
undetectable
6f6iB-3i5bA:
undetectable		 6f6iA-3i5bA:
18.12
6f6iB-3i5bA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_B_TRPB502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 3i5b WSPR RESPONSE
REGULATOR
(Pseudomonas
aeruginosa) 		5 / 10 ARG A 313
TYR A 250
ALA A 248
LEU A 205
VAL A 258
 None
 1.46A 6g2pB-3i5bA:
0.3		 6g2pB-3i5bA:
19.71