SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i5c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA699_1
(ADENOSINE KINASE)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 12 ASP A 226
LEU A 179
GLY A 225
ASN A 217
THR A 177
 None
 1.09A 1likA-3i5cA:
undetectable		 1likA-3i5cA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F9W_A_PAUA6002_0
(PANTOTHENATE KINASE)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		4 / 8 ARG A 182
GLY A 251
ARG A 249
THR A 177
 None
 0.91A 2f9wA-3i5cA:
undetectable
2f9wB-3i5cA:
undetectable		 2f9wA-3i5cA:
22.26
2f9wB-3i5cA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_2
(HIV-1 PROTEASE)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.78A 2hs1B-3i5cA:
undetectable		 2hs1B-3i5cA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VDB_A_NPSA1591_1
(SERUM ALBUMIN)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		4 / 8 ILE A 316
PHE A 312
LEU A 189
TYR A 250
 None
 0.95A 2vdbA-3i5cA:
undetectable		 2vdbA-3i5cA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		4 / 7 LEU A 189
ILE A 316
GLN A 321
ALA A 326
 None
 0.77A 2xkwA-3i5cA:
undetectable		 2xkwA-3i5cA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.69A 4q1xB-3i5cA:
undetectable		 4q1xB-3i5cA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 12 ILE A 208
ILE A 236
GLY A 239
VAL A 300
ILE A 298
 None
 0.78A 4q1yB-3i5cA:
undetectable		 4q1yB-3i5cA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 3i5c FUSION OF GENERAL
CONTROL PROTEIN GCN4
AND WSPR RESPONSE
REGULATOR PROTEIN
(Pseudomonas
aeruginosa;
Saccharomyces
cerevisiae) 		5 / 12 PHE A 185
ILE A 316
ALA A 256
SER A 301
LEU A 315
 None
 1.50A 4qztC-3i5cA:
undetectable		 4qztC-3i5cA:
20.40