SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i5m'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRE_B_CHDB701_0
(FERROCHELATASE)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		3 / 3 LYS A 279
GLY A 133
PRO A 132
 None
 0.87A 2hreB-3i5mA:
2.2		 2hreB-3i5mA:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_CCSB417_0
(ESTROGEN RECEPTOR)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		3 / 3 GLN A  72
LYS A 107
VAL A 109
 None
 0.89A 2jfaB-3i5mA:
undetectable		 2jfaB-3i5mA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		4 / 8 ASP A 292
SER A 218
HIS A 220
GLU A 148
 None
 1.01A 3sg9B-3i5mA:
undetectable		 3sg9B-3i5mA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_B_AERB601_1
(CYP17A1 PROTEIN)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		4 / 7 SER A 118
GLY A  17
ALA A  18
SER A  30
 None
 0.83A 4r1zB-3i5mA:
undetectable		 4r1zB-3i5mA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		5 / 9 THR A  90
PHE A 120
ILE A  22
GLY A 202
LEU A  57
 None
 1.39A 4ze0A-3i5mA:
undetectable		 4ze0A-3i5mA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		5 / 10 THR A  19
ALA A  16
THR A  90
SER A  89
ASP A  98
 None
 1.16A 5l66K-3i5mA:
undetectable
5l66L-3i5mA:
undetectable		 5l66K-3i5mA:
22.29
5l66L-3i5mA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA
TYPE-8,PROTEASOME
SUBUNIT BETA TYPE-5
PROTEASOME SUBUNIT
BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA
TYPE-6,PROTEASOME
SUBUNIT BETA
TYPE-1,PROTEASOME
SUBUNIT BETA TYPE-6)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		5 / 10 THR A  19
ALA A  16
THR A  90
SER A  89
ASP A  98
 None
 1.17A 5l66Y-3i5mA:
undetectable
5l66Z-3i5mA:
undetectable		 5l66Y-3i5mA:
22.29
5l66Z-3i5mA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 3i5m PUTATIVE
LEUCOANTHOCYANIDIN
REDUCTASE 1
(Vitis
vinifera) 		5 / 12 PHE A 204
ASN A 226
VAL A 196
THR A 205
GLU A 309
 None
 1.32A 5v1tA-3i5mA:
2.8		 5v1tA-3i5mA:
21.79