SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i5p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IKE_A_HSMA190_1
(NITROPHORIN 4)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1110
LEU A1103
LEU A1107
 None
 0.51A 1ikeA-3i5pA:
undetectable		 1ikeA-3i5pA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_B_HSMB304_1
(NITROPHORIN 1)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		3 / 3 ASP A1110
LEU A1103
LEU A1107
 None
 0.52A 1np1B-3i5pA:
undetectable		 1np1B-3i5pA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		4 / 7 PHE A1157
TYR A1152
ASN A1153
HIS A1158
 None
 1.18A 1wu8A-3i5pA:
undetectable
1wu8C-3i5pA:
undetectable		 1wu8A-3i5pA:
18.53
1wu8C-3i5pA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_0
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 ALA A1221
ILE A1301
ILE A1216
ALA A1214
PHE A1242
 None
 1.17A 2ejtA-3i5pA:
undetectable		 2ejtA-3i5pA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		3 / 3 LEU A1183
MET A1187
MET A1161
 None
 0.87A 2vavF-3i5pA:
undetectable		 2vavF-3i5pA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		4 / 6 GLU A1447
MET A1426
PHE A1416
ILE A1417
 None
 1.18A 2w98B-3i5pA:
undetectable		 2w98B-3i5pA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		3 / 3 VAL A1051
SER A1063
LEU A1055
 None
 0.65A 3n8xA-3i5pA:
undetectable		 3n8xA-3i5pA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.01A 3nt1A-3i5pA:
undetectable		 3nt1A-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.03A 3nt1B-3i5pA:
undetectable		 3nt1B-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA303_1
(CHITOSANASE)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		4 / 6 GLU A1234
ILE A1227
THR A1228
TYR A1204
 None
 1.00A 4qwpA-3i5pA:
1.4		 4qwpA-3i5pA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.00A 4rrwA-3i5pA:
undetectable		 4rrwA-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRW_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.02A 4rrwC-3i5pA:
undetectable		 4rrwC-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_A_LURA706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.02A 4rrxA-3i5pA:
undetectable		 4rrxA-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRX_B_LURB706_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.02A 4rrxB-3i5pA:
undetectable		 4rrxB-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_A_LURA705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.00A 4rrzA-3i5pA:
undetectable		 4rrzA-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RRZ_C_LURC705_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.02A 4rrzC-3i5pA:
undetectable		 4rrzC-3i5pA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKR_A_ID8A601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 1.10A 5ikrA-3i5pA:
undetectable		 5ikrA-3i5pA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JVZ_A_FLPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		5 / 12 LEU A1307
VAL A1268
GLY A1270
ALA A1269
LEU A1229
 None
 0.99A 5jvzA-3i5pA:
undetectable		 5jvzA-3i5pA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_B_NOVB403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		4 / 7 ARG A1238
LEU A1236
ALA A1269
GLN A1272
 None
 1.10A 6b89A-3i5pA:
undetectable		 6b89A-3i5pA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F32_B_ACTB602_0
(AMINE OXIDASE LKCE)		 3i5p NUCLEOPORIN NUP170
(Saccharomyces
cerevisiae) 		4 / 6 TYR A1060
VAL A1051
VAL A1108
THR A1111
 None
 1.46A 6f32B-3i5pA:
undetectable		 6f32B-3i5pA:
22.81