SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i5t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 8 PHE A 271
GLY A 265
ARG A 266
LEU A 430
 None
 0.85A 1gsfA-3i5tA:
undetectable		 1gsfA-3i5tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 8 PHE A 271
GLY A 265
ARG A 266
LEU A 430
 None
 0.85A 1gsfB-3i5tA:
undetectable		 1gsfB-3i5tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 8 PHE A 271
GLY A 265
ARG A 266
LEU A 430
 None
 0.85A 1gsfC-3i5tA:
undetectable		 1gsfC-3i5tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 8 PHE A 271
GLY A 265
ARG A 266
LEU A 430
 None
 0.85A 1gsfD-3i5tA:
undetectable		 1gsfD-3i5tA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CIZ_A_ACTA1320_0
(CHLOROPEROXIDASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 ALA A 162
ILE A 146
VAL A 148
PHE A 182
 None
 0.87A 2cizA-3i5tA:
undetectable		 2cizA-3i5tA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UVN_A_ECNA1409_1
(CYTOCHROME P450 130)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 LEU A 128
THR A 285
GLY A 299
GLY A 298
THR A 117
 None
 0.96A 2uvnA-3i5tA:
undetectable		 2uvnA-3i5tA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 7 THR A 107
PHE A 286
PHE A 116
ILE A 114
 None
 0.82A 2y7wC-3i5tA:
undetectable		 2y7wC-3i5tA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK2_X_LDPX433_1
(6-HYDROXY-L-NICOTINE
OXIDASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 7 ASN A 322
LEU A 159
LEU A 300
PHE A 320
 None
 1.26A 3nk2X-3i5tA:
undetectable		 3nk2X-3i5tA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 TYR A 255
ALA A 220
ILE A 211
PHE A 222
ASP A 252
 None
 1.09A 3nmuB-3i5tA:
undetectable
3nmuJ-3i5tA:
undetectable		 3nmuB-3i5tA:
20.98
3nmuJ-3i5tA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 VAL A 279
TYR A 255
GLU A 259
ILE A 284
 None
 1.05A 3q5sA-3i5tA:
undetectable		 3q5sA-3i5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLN A  64
GLY A 265
ILE A 437
ALA A 352
ALA A 356
 None
 1.11A 3sudB-3i5tA:
undetectable		 3sudB-3i5tA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UUD_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 11 ALA A 373
LEU A 387
LEU A 388
GLY A 421
LEU A 423
 None
 1.29A 3uudA-3i5tA:
undetectable		 3uudA-3i5tA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 GLY A 231
SER A 230
TRP A  61
 None
PLP  A 474 ( 4.0A)
None
 0.97A 4e7cD-3i5tA:
undetectable		 4e7cD-3i5tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 5 SER A 121
TYR A 153
VAL A 261
ASP A 258
 PLP  A 474 (-2.5A)
PLP  A 474 (-4.5A)
PLP  A 474 (-4.8A)
PLP  A 474 (-2.8A)
 1.19A 4eohB-3i5tA:
3.1		 4eohB-3i5tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB0_A_ACTA401_0
(UNCHARACTERIZED
PROTEIN)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 9 SER A 121
GLY A 120
TYR A 324
GLY A 119
THR A 122
 PLP  A 474 (-2.5A)
PLP  A 474 (-3.2A)
None
PLP  A 474 ( 4.1A)
None
 1.45A 4lb0A-3i5tA:
undetectable		 4lb0A-3i5tA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_A_STRA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 271
ASN A 339
ILE A 340
GLY A 289
ILE A 284
 None
 1.03A 4nkxA-3i5tA:
undetectable		 4nkxA-3i5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 271
ASN A 339
ILE A 340
GLY A 289
ILE A 284
 None
 0.97A 4nkxC-3i5tA:
undetectable		 4nkxC-3i5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 PHE A 271
ASN A 339
ILE A 340
GLY A 289
ILE A 284
 None
 0.94A 4nkxD-3i5tA:
undetectable		 4nkxD-3i5tA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 2)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 PHE A 320
THR A 160
LEU A 300
 None
 0.72A 4qztA-3i5tA:
1.4		 4qztA-3i5tA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 ILE A 103
ALA A 104
GLY A 263
PHE A 286
VAL A 290
 None
 1.27A 5i71A-3i5tA:
undetectable		 5i71A-3i5tA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 ILE A 437
ILE A 426
MET A 355
 None
 0.58A 5i9yA-3i5tA:
undetectable		 5i9yA-3i5tA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 298
VAL A 260
PHE A 264
ILE A  72
ALA A 335
 None
PLP  A 474 (-4.1A)
None
None
None
 1.02A 5n0sA-3i5tA:
1.7		 5n0sA-3i5tA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 298
VAL A 260
PHE A 264
ILE A  72
ALA A 335
 None
PLP  A 474 (-4.1A)
None
None
None
 1.09A 5n0tA-3i5tA:
undetectable		 5n0tA-3i5tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLY A 298
VAL A 260
PHE A 264
ILE A  72
ALA A 335
 None
PLP  A 474 (-4.1A)
None
None
None
 1.06A 5n0xA-3i5tA:
undetectable		 5n0xA-3i5tA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYE_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		5 / 12 GLU A 225
ASP A 258
LEU A 430
ALA A 272
SER A 273
 PLP  A 474 (-3.9A)
PLP  A 474 (-2.8A)
None
None
None
 1.13A 5syeB-3i5tA:
4.8		 5syeB-3i5tA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 6 THR A 218
ARG A 145
ILE A 211
GLU A 212
 None
 1.11A 5uigA-3i5tA:
undetectable		 5uigA-3i5tA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 ARG A 179
PHE A 222
LEU A 128
 None
 0.63A 5x1bC-3i5tA:
undetectable		 5x1bC-3i5tA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_A_SALA201_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		4 / 5 VAL A 204
PRO A 237
GLY A 239
TYR A 240
 None
 1.23A 5x80A-3i5tA:
2.4
5x80B-3i5tA:
2.7		 5x80A-3i5tA:
15.51
5x80B-3i5tA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3i5t AMINOTRANSFERASE
(Rhodobacter
sphaeroides) 		3 / 3 ASN A 169
VAL A 148
HIS A 154
 None
 0.68A 6a5yD-3i5tA:
undetectable		 6a5yD-3i5tA:
9.70