SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i6b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 5 VAL A  33
SER A  38
ASP A  85
GLN A  97
 PO4  A 800 (-3.9A)
None
None
None
 1.08A 1n2xB-3i6bA:
3.0		 1n2xB-3i6bA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KAW_A_SUZA91_1
(SEGMENT POLARITY
PROTEIN DISHEVELLED
HOMOLOG DVL-1)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		5 / 11 LEU A  90
GLY A  91
ILE A  74
VAL A  33
LEU A  37
 None
None
None
PO4  A 800 (-3.9A)
None
 0.93A 2kawA-3i6bA:
undetectable		 2kawA-3i6bA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 5 LEU A  29
ALA A  65
LEU A 174
MET A  20
 None
 0.98A 2oaxA-3i6bA:
undetectable		 2oaxA-3i6bA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA607_1
(CHITINASE A)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 8 VAL A  83
GLY A  77
THR A  76
GLU A  50
 None
PO4  A 800 (-4.1A)
PO4  A 800 (-3.8A)
None
 0.75A 3aruA-3i6bA:
undetectable		 3aruA-3i6bA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		5 / 12 ALA A 165
GLY A 161
LEU A  37
SER A  38
LEU A  29
 None
 1.31A 3bxoA-3i6bA:
3.1		 3bxoA-3i6bA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_1
(CDL2.2)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		5 / 12 LEU A 138
ILE A  74
THR A 157
ALA A 165
LEU A  37
 None
 1.24A 5ienA-3i6bA:
undetectable		 5ienA-3i6bA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		5 / 9 VAL A  36
ASP A  32
LEU A 173
ALA A 121
VAL A 120
 None
PO4  A 800 ( 4.3A)
None
None
None
 1.33A 6c2mB-3i6bA:
undetectable		 6c2mB-3i6bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 4 ASP A 125
ILE A 150
PRO A 151
LEU A 149
 MG  A 201 (-4.0A)
None
None
None
 1.15A 6mkeB-3i6bA:
undetectable		 6mkeB-3i6bA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 4 ASP A 126
ILE A 150
PRO A 151
LEU A 149
 None
 1.18A 6mkeB-3i6bA:
undetectable		 6mkeB-3i6bA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 4 ASP A 125
ILE A 150
PRO A 151
LEU A 149
 MG  A 201 (-4.0A)
None
None
None
 1.12A 6mkeA-3i6bA:
undetectable		 6mkeA-3i6bA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE
(Escherichia
coli) 		4 / 4 ASP A 126
ILE A 150
PRO A 151
LEU A 149
 None
 1.16A 6mkeA-3i6bA:
undetectable		 6mkeA-3i6bA:
17.13