SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i6d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

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	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1P33_A_MTXA351_1 (PTERIDINE REDUCTASE 1)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	SER A 144 ASP A 149 LEU A 184 LEU A 173 TYR A 177	PO4 A 472 (-3.3A) None None None None	1.30A	1p33A-3i6dA: 4.4	1p33A-3i6dA: 22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SN5_C_T3C601_1 (TRANSTHYRETIN)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	4 / 6	LEU A 316 ALA A 365 LEU A 363 VAL A 367	None	1.19A	1sn5A-3i6dA: undetectable	1sn5A-3i6dA: 15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FK8_A_SAMA302_1 (METHOXY MYCOLIC ACID SYNTHASE 4)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	3 / 3	SER A 188 THR A 441 GLN A 456	None	0.83A	2fk8A-3i6dA: 2.1	2fk8A-3i6dA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2FN1_A_SALA506_1 (SALICYLATE SYNTHETASE, IRP9)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 11	ILE A 10 GLY A 47 LEU A 245 GLY A 12 GLU A 41	None None None FAD A 600 (-3.4A) FAD A 600 (-2.7A)	1.23A	2fn1A-3i6dA: undetectable	2fn1A-3i6dA: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PRG_B_BRLB2_1 (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	TYR A 266 LEU A 259 VAL A 256 LEU A 468 TYR A 467	None None FAD A 600 (-4.3A) None None	1.41A	2prgB-3i6dA: undetectable	2prgB-3i6dA: 20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XH9_A_J01A1437_1 (ORF12)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 11	SER A 174 THR A 343 ALA A 370 GLY A 179 ALA A 178	None	1.28A	2xh9A-3i6dA: undetectable	2xh9A-3i6dA: 22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BJW_F_SVRF509_3 (PHOSPHOLIPASE A2)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	4 / 7	VAL A 78 ILE A 241 GLN A 244 LEU A 37	None	0.90A	3bjwF-3i6dA: undetectable	3bjwF-3i6dA: 14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_C_ROFC903_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	3 / 3	SER A 151 GLN A 150 PHE A 155	None PO4 A 472 (-2.8A) None	0.81A	3g4lC-3i6dA: undetectable	3g4lC-3i6dA: 24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJD_B_C2FB314_0 (UNCHARACTERIZED PROTEIN)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	LEU A 297 VAL A 438 GLY A 437 LEU A 427 ILE A 424	None	1.16A	3ijdB-3i6dA: undetectable	3ijdB-3i6dA: 20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LCV_B_SAMB301_1 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	3 / 3	ARG A 428 ASP A 452 GLN A 192	None	0.95A	3lcvB-3i6dA: undetectable	3lcvB-3i6dA: 20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4MBS_A_MRVA1101_2 (CHIMERA PROTEIN OF C-C CHEMOKINE RECEPTOR TYPE 5 AND RUBREDOXIN)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	4 / 7	GLN A 228 THR A 229 LEU A 234 THR A 16	None None None FAD A 600 (-3.4A)	0.80A	4mbsA-3i6dA: undetectable	4mbsA-3i6dA: 21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PCL_A_SAMA301_0 (O-METHYLTRANSFERASE FAMILY PROTEIN)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	GLY A 457 PHE A 22 ASP A 452 GLU A 446 ALA A 459	None	1.14A	4pclA-3i6dA: undetectable	4pclA-3i6dA: 18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4R1Z_A_AERA601_1 (CYP17A1 PROTEIN)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 9	SER A 374 ILE A 375 GLY A 371 ALA A 370 THR A 309	None	1.17A	4r1zA-3i6dA: undetectable	4r1zA-3i6dA: 21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4WG0_M_CHDM103_0 (NUCLEAR RECEPTOR COACTIVATOR 2)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 11	ALA A 21 TYR A 23 GLU A 242 LEU A 81 LEU A 77	None	1.15A	4wg0K-3i6dA: undetectable 4wg0L-3i6dA: undetectable 4wg0M-3i6dA: undetectable	4wg0K-3i6dA: 3.93 4wg0L-3i6dA: 3.93 4wg0M-3i6dA: 3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XDT_A_ACTA409_0 (FAD:PROTEIN FMN TRANSFERASE)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	4 / 5	VAL A 387 ILE A 384 VAL A 314 THR A 404	None	0.73A	4xdtA-3i6dA: undetectable	4xdtA-3i6dA: 21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEU_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5eeuF-3i6dA: undetectable 5eeuG-3i6dA: undetectable	5eeuF-3i6dA: 14.25 5eeuG-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEU_I_TRPI101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.04A	5eeuI-3i6dA: undetectable 5eeuJ-3i6dA: undetectable	5eeuI-3i6dA: 14.25 5eeuJ-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEV_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5eevF-3i6dA: undetectable 5eevG-3i6dA: undetectable	5eevF-3i6dA: 14.25 5eevG-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEV_I_TRPI101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.04A	5eevI-3i6dA: undetectable 5eevJ-3i6dA: undetectable	5eevI-3i6dA: 14.25 5eevJ-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEW_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5eewF-3i6dA: undetectable 5eewG-3i6dA: undetectable	5eewF-3i6dA: 14.25 5eewG-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEW_I_TRPI101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.03A	5eewI-3i6dA: undetectable 5eewJ-3i6dA: undetectable	5eewI-3i6dA: 14.25 5eewJ-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEX_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5eexF-3i6dA: undetectable 5eexG-3i6dA: undetectable	5eexF-3i6dA: 14.25 5eexG-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEY_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5eeyF-3i6dA: undetectable 5eeyG-3i6dA: undetectable	5eeyF-3i6dA: 14.25 5eeyG-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EEZ_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5eezF-3i6dA: undetectable 5eezG-3i6dA: undetectable	5eezF-3i6dA: 14.25 5eezG-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF0_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5ef0F-3i6dA: undetectable 5ef0G-3i6dA: undetectable	5ef0F-3i6dA: 14.25 5ef0G-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF1_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5ef1F-3i6dA: undetectable 5ef1G-3i6dA: undetectable	5ef1F-3i6dA: 14.25 5ef1G-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF2_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5ef2F-3i6dA: undetectable 5ef2G-3i6dA: undetectable	5ef2F-3i6dA: 14.25 5ef2G-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5EF3_F_TRPF101_0 (TRANSCRIPTION ATTENUATION PROTEIN MTRB)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 10	ALA A 19 GLY A 12 ALA A 20 THR A 284 ILE A 10	None FAD A 600 (-3.4A) None None None	1.06A	5ef3F-3i6dA: undetectable 5ef3G-3i6dA: undetectable	5ef3F-3i6dA: 14.25 5ef3G-3i6dA: 14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW4_A_SAMA801_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	GLY A 331 THR A 346 CYH A 345 LEU A 98 VAL A 394	None	1.05A	5hw4A-3i6dA: undetectable	5hw4A-3i6dA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW4_A_SAMA801_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	ILE A 10 GLY A 17 THR A 16 ALA A 21 LEU A 37	None None FAD A 600 (-3.4A) None None	1.18A	5hw4A-3i6dA: undetectable	5hw4A-3i6dA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW4_C_SAMC801_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	GLY A 331 THR A 346 CYH A 345 LEU A 98 VAL A 394	None	1.07A	5hw4C-3i6dA: undetectable	5hw4C-3i6dA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5HW4_C_SAMC801_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	ILE A 10 GLY A 17 THR A 16 ALA A 21 LEU A 37	None None FAD A 600 (-3.4A) None None	1.23A	5hw4C-3i6dA: undetectable	5hw4C-3i6dA: 19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGJ_A_CTYA402_1 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	VAL A 314 ALA A 344 VAL A 387 GLY A 331 THR A 330	None	0.96A	5igjA-3i6dA: undetectable	5igjA-3i6dA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGP_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	PRO A 401 VAL A 314 ALA A 344 VAL A 387 GLY A 331	None	0.83A	5igpA-3i6dA: undetectable	5igpA-3i6dA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGP_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	PRO A 401 VAL A 314 VAL A 387 GLY A 331 THR A 330	None	0.94A	5igpA-3i6dA: undetectable	5igpA-3i6dA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IGT_A_ERYA402_0 (MACROLIDE 2'-PHOSPHOTRANSFERAS E)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	6 / 12	PRO A 401 VAL A 314 ALA A 344 VAL A 387 GLY A 331 THR A 330	None	0.95A	5igtA-3i6dA: undetectable	5igtA-3i6dA: 20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5N0S_B_SAMB501_1 (PEPTIDE N-METHYLTRANSFERASE)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	4 / 4	GLY A 57 ALA A 356 MET A 403 THR A 348	None	1.16A	5n0sB-3i6dA: undetectable	5n0sB-3i6dA: 23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZY_A_CE3A1103_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	4 / 8	TYR A 177 GLN A 192 VAL A 448 GLY A 449	None None FAD A 600 (-4.4A) FAD A 600 ( 3.7A)	0.85A	5nzyA-3i6dA: undetectable	5nzyA-3i6dA: 22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5UUN_B_ACTB309_0 (GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	3 / 3	TYR A 266 ALA A 434 TYR A 435	None	0.74A	5uunB-3i6dA: undetectable	5uunB-3i6dA: 22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VW9_A_NCAA403_0 (FERREDOXIN--NADP REDUCTASE)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	4 / 8	THR A 16 GLY A 17 ALA A 20 GLY A 12	FAD A 600 (-3.4A) None None FAD A 600 (-3.4A)	0.70A	5vw9A-3i6dA: 4.2	5vw9A-3i6dA: 19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5WZ1_B_SAMB601_0 (NS5 METHYLTRANSFERASE)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	6 / 12	GLY A 399 GLY A 317 GLY A 321 GLU A 402 VAL A 314 ILE A 384	None	1.41A	5wz1B-3i6dA: undetectable	5wz1B-3i6dA: 21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6IFT_A_SAMA301_0 (RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A)	3i6d	PROTOPORPHYRINOGEN OXIDASE (Bacillus subtilis)	5 / 12	ILE A 11 GLY A 12 GLY A 14 ALA A 19 VAL A 256	None FAD A 600 (-3.4A) FAD A 600 (-3.2A) None FAD A 600 (-4.3A)	0.76A	6iftA-3i6dA: 2.9	6iftA-3i6dA: 21.59

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1P33_A_MTXA351_1","PTERIDINE REDUCTASE 1","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"SER A 144;ASP A 149;LEU A 184;LEU A 173;TYR A 177","PO4 A 472 (-3.3A);None;None;None;None","1.30A","1p33A-3i6dA:4.4","1p33A-3i6dA:22.06"],["1SN5_C_T3C601_1","TRANSTHYRETIN;TRANSTHYRETIN","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",4,"LEU A 316;ALA A 365;LEU A 363;VAL A 367","None","1.19A","1sn5A-3i6dA:undetectable","1sn5A-3i6dA:15.17"],["2FK8_A_SAMA302_1","METHOXY MYCOLIC ACID SYNTHASE 4","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",3,"SER A 188;THR A 441;GLN A 456","None","0.83A","2fk8A-3i6dA:2.1","2fk8A-3i6dA:22.27"],["2FN1_A_SALA506_1","SALICYLATE SYNTHETASE, IRP9","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ILE A  10;GLY A  47;LEU A 245;GLY A  12;GLU A  41","None;None;None;FAD A 600 (-3.4A);FAD A 600 (-2.7A)","1.23A","2fn1A-3i6dA:undetectable","2fn1A-3i6dA:21.41"],["2PRG_B_BRLB2_1","PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"TYR A 266;LEU A 259;VAL A 256;LEU A 468;TYR A 467","None;None;FAD A 600 (-4.3A);None;None","1.41A","2prgB-3i6dA:undetectable","2prgB-3i6dA:20.43"],["2XH9_A_J01A1437_1","ORF12","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"SER A 174;THR A 343;ALA A 370;GLY A 179;ALA A 178","None","1.28A","2xh9A-3i6dA:undetectable","2xh9A-3i6dA:22.99"],["3BJW_F_SVRF509_3","PHOSPHOLIPASE A2","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",4,"VAL A  78;ILE A 241;GLN A 244;LEU A  37","None","0.90A","3bjwF-3i6dA:undetectable","3bjwF-3i6dA:14.19"],["3G4L_C_ROFC903_1","CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",3,"SER A 151;GLN A 150;PHE A 155","None;PO4 A 472 (-2.8A);None","0.81A","3g4lC-3i6dA:undetectable","3g4lC-3i6dA:24.34"],["3IJD_B_C2FB314_0","UNCHARACTERIZED PROTEIN","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"LEU A 297;VAL A 438;GLY A 437;LEU A 427;ILE A 424","None","1.16A","3ijdB-3i6dA:undetectable","3ijdB-3i6dA:20.95"],["3LCV_B_SAMB301_1","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",3,"ARG A 428;ASP A 452;GLN A 192","None","0.95A","3lcvB-3i6dA:undetectable","3lcvB-3i6dA:20.72"],["4MBS_A_MRVA1101_2","CHIMERA PROTEIN OF C-C CHEMOKINE RECEPTOR TYPE 5 AND RUBREDOXIN","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",4,"GLN A 228;THR A 229;LEU A 234;THR A  16","None;None;None;FAD A 600 (-3.4A)","0.80A","4mbsA-3i6dA:undetectable","4mbsA-3i6dA:21.83"],["4PCL_A_SAMA301_0","O-METHYLTRANSFERASE FAMILY PROTEIN","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"GLY A 457;PHE A  22;ASP A 452;GLU A 446;ALA A 459","None","1.14A","4pclA-3i6dA:undetectable","4pclA-3i6dA:18.43"],["4R1Z_A_AERA601_1","CYP17A1 PROTEIN","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"SER A 374;ILE A 375;GLY A 371;ALA A 370;THR A 309","None","1.17A","4r1zA-3i6dA:undetectable","4r1zA-3i6dA:21.92"],["4WG0_M_CHDM103_0","NUCLEAR RECEPTOR COACTIVATOR 2","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  21;TYR A  23;GLU A 242;LEU A  81;LEU A  77","None","1.15A","4wg0K-3i6dA:undetectable;4wg0L-3i6dA:undetectable;4wg0M-3i6dA:undetectable","4wg0K-3i6dA:3.93;4wg0L-3i6dA:3.93;4wg0M-3i6dA:3.93"],["4XDT_A_ACTA409_0","FAD:PROTEIN FMN TRANSFERASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",4,"VAL A 387;ILE A 384;VAL A 314;THR A 404","None","0.73A","4xdtA-3i6dA:undetectable","4xdtA-3i6dA:21.50"],["5EEU_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5eeuF-3i6dA:undetectable;5eeuG-3i6dA:undetectable","5eeuF-3i6dA:14.25;5eeuG-3i6dA:14.25"],["5EEU_I_TRPI101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.04A","5eeuI-3i6dA:undetectable;5eeuJ-3i6dA:undetectable","5eeuI-3i6dA:14.25;5eeuJ-3i6dA:14.25"],["5EEV_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5eevF-3i6dA:undetectable;5eevG-3i6dA:undetectable","5eevF-3i6dA:14.25;5eevG-3i6dA:14.25"],["5EEV_I_TRPI101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.04A","5eevI-3i6dA:undetectable;5eevJ-3i6dA:undetectable","5eevI-3i6dA:14.25;5eevJ-3i6dA:14.25"],["5EEW_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5eewF-3i6dA:undetectable;5eewG-3i6dA:undetectable","5eewF-3i6dA:14.25;5eewG-3i6dA:14.25"],["5EEW_I_TRPI101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.03A","5eewI-3i6dA:undetectable;5eewJ-3i6dA:undetectable","5eewI-3i6dA:14.25;5eewJ-3i6dA:14.25"],["5EEX_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5eexF-3i6dA:undetectable;5eexG-3i6dA:undetectable","5eexF-3i6dA:14.25;5eexG-3i6dA:14.25"],["5EEY_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5eeyF-3i6dA:undetectable;5eeyG-3i6dA:undetectable","5eeyF-3i6dA:14.25;5eeyG-3i6dA:14.25"],["5EEZ_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5eezF-3i6dA:undetectable;5eezG-3i6dA:undetectable","5eezF-3i6dA:14.25;5eezG-3i6dA:14.25"],["5EF0_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5ef0F-3i6dA:undetectable;5ef0G-3i6dA:undetectable","5ef0F-3i6dA:14.25;5ef0G-3i6dA:14.25"],["5EF1_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5ef1F-3i6dA:undetectable;5ef1G-3i6dA:undetectable","5ef1F-3i6dA:14.25;5ef1G-3i6dA:14.25"],["5EF2_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5ef2F-3i6dA:undetectable;5ef2G-3i6dA:undetectable","5ef2F-3i6dA:14.25;5ef2G-3i6dA:14.25"],["5EF3_F_TRPF101_0","TRANSCRIPTION ATTENUATION PROTEIN MTRB","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ALA A  19;GLY A  12;ALA A  20;THR A 284;ILE A  10","None;FAD A 600 (-3.4A);None;None;None","1.06A","5ef3F-3i6dA:undetectable;5ef3G-3i6dA:undetectable","5ef3F-3i6dA:14.25;5ef3G-3i6dA:14.25"],["5HW4_A_SAMA801_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"GLY A 331;THR A 346;CYH A 345;LEU A  98;VAL A 394","None","1.05A","5hw4A-3i6dA:undetectable","5hw4A-3i6dA:19.33"],["5HW4_A_SAMA801_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ILE A  10;GLY A  17;THR A  16;ALA A  21;LEU A  37","None;None;FAD A 600 (-3.4A);None;None","1.18A","5hw4A-3i6dA:undetectable","5hw4A-3i6dA:19.33"],["5HW4_C_SAMC801_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"GLY A 331;THR A 346;CYH A 345;LEU A  98;VAL A 394","None","1.07A","5hw4C-3i6dA:undetectable","5hw4C-3i6dA:19.33"],["5HW4_C_SAMC801_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE I","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ILE A  10;GLY A  17;THR A  16;ALA A  21;LEU A  37","None;None;FAD A 600 (-3.4A);None;None","1.23A","5hw4C-3i6dA:undetectable","5hw4C-3i6dA:19.33"],["5IGJ_A_CTYA402_1","MACROLIDE 2'-PHOSPHOTRANSFERASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"VAL A 314;ALA A 344;VAL A 387;GLY A 331;THR A 330","None","0.96A","5igjA-3i6dA:undetectable","5igjA-3i6dA:20.60"],["5IGP_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"PRO A 401;VAL A 314;ALA A 344;VAL A 387;GLY A 331","None","0.83A","5igpA-3i6dA:undetectable","5igpA-3i6dA:20.60"],["5IGP_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"PRO A 401;VAL A 314;VAL A 387;GLY A 331;THR A 330","None","0.94A","5igpA-3i6dA:undetectable","5igpA-3i6dA:20.60"],["5IGT_A_ERYA402_0","MACROLIDE 2'-PHOSPHOTRANSFERASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",6,"PRO A 401;VAL A 314;ALA A 344;VAL A 387;GLY A 331;THR A 330","None","0.95A","5igtA-3i6dA:undetectable","5igtA-3i6dA:20.60"],["5N0S_B_SAMB501_1","PEPTIDE N-METHYLTRANSFERASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",4,"GLY A  57;ALA A 356;MET A 403;THR A 348","None","1.16A","5n0sB-3i6dA:undetectable","5n0sB-3i6dA:23.67"],["5NZY_A_CE3A1103_1","DNA CROSS-LINK REPAIR 1A PROTEIN","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",4,"TYR A 177;GLN A 192;VAL A 448;GLY A 449","None;None;FAD A 600 (-4.4A);FAD A 600 ( 3.7A)","0.85A","5nzyA-3i6dA:undetectable","5nzyA-3i6dA:22.92"],["5UUN_B_ACTB309_0","GLUTATHIONE S-TRANSFERASE-LIKE PROTEIN","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",3,"TYR A 266;ALA A 434;TYR A 435","None","0.74A","5uunB-3i6dA:undetectable","5uunB-3i6dA:22.48"],["5VW9_A_NCAA403_0","FERREDOXIN--NADP REDUCTASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",4,"THR A  16;GLY A  17;ALA A  20;GLY A  12","FAD A 600 (-3.4A);None;None;FAD A 600 (-3.4A)","0.70A","5vw9A-3i6dA:4.2","5vw9A-3i6dA:19.80"],["5WZ1_B_SAMB601_0","NS5 METHYLTRANSFERASE","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",6,"GLY A 399;GLY A 317;GLY A 321;GLU A 402;VAL A 314;ILE A 384","None","1.41A","5wz1B-3i6dA:undetectable","5wz1B-3i6dA:21.20"],["6IFT_A_SAMA301_0","RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE A","3i6d","PROTOPORPHYRINOGEN OXIDASE","Bacillus subtilis",5,"ILE A  11;GLY A  12;GLY A  14;ALA A  19;VAL A 256","None;FAD A 600 (-3.4A);FAD A 600 (-3.2A);None;FAD A 600 (-4.3A)","0.76A","6iftA-3i6dA:2.9","6iftA-3i6dA:21.59"]]