SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i6e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G50_A_ESTA600_1
(ESTROGEN RECEPTOR)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 11 LEU A 114
LEU A 117
ALA A 118
LEU A   6
MET A  93
 None
 1.11A 1g50A-3i6eA:
undetectable		 1g50A-3i6eA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NH8_A_HISA289_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 5 ASP A 338
LEU A  18
ALA A 363
LEU A 340
 None
 1.13A 1nh8A-3i6eA:
undetectable		 1nh8A-3i6eA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA501_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 ASP A 249
GLY A 300
ASP A 301
ILE A 274
ALA A 109
 MG  A 386 (-3.1A)
None
None
None
None
 1.36A 1oltA-3i6eA:
3.4		 1oltA-3i6eA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 MET A 235
LEU A 238
LEU A 241
GLN A 225
ILE A 266
 None
 1.24A 1p93A-3i6eA:
undetectable		 1p93A-3i6eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_A_DEXA1999_1
(GLUCOCORTICOID
RECEPTOR)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 MET A 235
LEU A 238
LEU A 241
GLY A 240
GLN A 225
 None
None
None
NA  A 387 ( 4.4A)
None
 1.48A 1p93A-3i6eA:
undetectable		 1p93A-3i6eA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG1_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		3 / 3 TRP A 127
VAL A 126
PRO A 125
 None
 1.00A 1rg1A-3i6eA:
undetectable		 1rg1A-3i6eA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH0_A_SPMA999_1
(TYROSYL-DNA
PHOSPHODIESTERASE 1)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		3 / 3 TRP A 127
VAL A 126
PRO A 125
 None
 0.99A 1rh0A-3i6eA:
undetectable		 1rh0A-3i6eA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		3 / 3 SER A 122
VAL A  86
LEU A   6
 None
 0.68A 1yajG-3i6eA:
undetectable		 1yajG-3i6eA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA6_A_STRA401_1
(MINERALOCORTICOID
RECEPTOR)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 LEU A 114
LEU A 117
ALA A 118
MET A  93
THR A 281
 None
 1.30A 2aa6A-3i6eA:
undetectable		 2aa6A-3i6eA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_A_SAMA2001_0
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 TYR A 298
LEU A 247
ASP A 221
VAL A 195
ALA A 145
 None
 1.35A 2g72A-3i6eA:
undetectable		 2g72A-3i6eA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JIH_A_097A1001_1
(ADAMTS-1)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 9 ASP A 116
LEU A 307
HIS A 309
GLU A 304
LEU A 340
 None
 1.49A 2jihA-3i6eA:
undetectable		 2jihA-3i6eA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D90_B_NOGB2001_1
(PROGESTERONE
RECEPTOR)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 LEU A  18
LEU A  20
LEU A 307
LEU A  15
TYR A  70
 None
 1.20A 3d90B-3i6eA:
undetectable		 3d90B-3i6eA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 7 LEU A 359
ARG A  89
GLY A 279
MET A 275
 None
 1.08A 3hcrB-3i6eA:
2.2		 3hcrB-3i6eA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 5 ILE A 274
ALA A 283
HIS A 314
MET A 315
 None
 1.22A 4ac9B-3i6eA:
3.9
4ac9C-3i6eA:
2.7		 4ac9B-3i6eA:
21.09
4ac9C-3i6eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 5 ILE A 274
ALA A 283
HIS A 314
MET A 315
 None
 1.19A 4acaB-3i6eA:
4.4
4acaC-3i6eA:
2.7		 4acaB-3i6eA:
21.09
4acaC-3i6eA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 LEU A  44
GLY A 119
LEU A 114
ASP A 116
GLY A  87
 None
 1.02A 4blvA-3i6eA:
undetectable		 4blvA-3i6eA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 ILE A 138
LEU A 310
GLY A 306
VAL A 346
ILE A 352
 None
 0.96A 4c9lA-3i6eA:
undetectable		 4c9lA-3i6eA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_B_CAMB1419_0
(CYTOCHROME P450)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 ILE A 138
LEU A 310
GLY A 306
VAL A 346
ILE A 352
 None
 0.92A 4c9lB-3i6eA:
undetectable		 4c9lB-3i6eA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 8 LEU A  42
ILE A  10
VAL A  86
GLY A  52
 None
 0.80A 4eq4B-3i6eA:
undetectable		 4eq4B-3i6eA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		3 / 3 ASP A 268
ARG A 239
ASP A 243
 NA  A 387 ( 4.2A)
None
None
 0.82A 4fzvA-3i6eA:
undetectable		 4fzvA-3i6eA:
25.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_B_SAMB401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 GLY A 312
THR A 319
LEU A 359
ILE A 274
ASP A 111
 None
 1.27A 4pghB-3i6eA:
2.1		 4pghB-3i6eA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 GLU A 341
LEU A 359
GLY A 306
ALA A 308
LEU A 368
 None
 1.07A 4retC-3i6eA:
undetectable		 4retC-3i6eA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 7 ALA A  56
ASP A  14
ARG A  43
GLY A  52
GLU A  51
 None
 1.44A 5btgA-3i6eA:
undetectable
5btgC-3i6eA:
undetectable
5btgD-3i6eA:
2.8		 5btgA-3i6eA:
25.49
5btgC-3i6eA:
25.49
5btgD-3i6eA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 GLY A 172
PHE A 173
MET A 156
ASP A 179
PHE A 178
 None
 1.05A 5nknA-3i6eA:
undetectable		 5nknA-3i6eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NKN_A_LOCA201_1
(NEUTROPHIL
GELATINASE-ASSOCIATE
D LIPOCALIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 GLY A 172
PHE A 173
MET A 156
LEU A 185
ASP A 179
 None
 1.15A 5nknA-3i6eA:
undetectable		 5nknA-3i6eA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB310_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 4 GLY A 254
PRO A 255
VAL A 286
ARG A 282
 None
 1.30A 5uunA-3i6eA:
0.0
5uunB-3i6eA:
0.0		 5uunA-3i6eA:
22.14
5uunB-3i6eA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_B_ZITB501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 12 ILE A 223
LEU A 247
ASP A 249
LEU A 183
GLY A 325
 None
None
MG  A 386 (-3.1A)
None
None
 1.09A 5uxdB-3i6eA:
undetectable		 5uxdB-3i6eA:
26.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VYH_A_FOLA409_0
(S PROTEIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		5 / 10 PRO A  66
HIS A  17
GLY A 312
ILE A 274
ALA A 109
 None
 0.92A 5vyhA-3i6eA:
undetectable		 5vyhA-3i6eA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W3J_B_TA1B502_1
(TUBULIN BETA CHAIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 8 VAL A 197
ASP A 198
GLY A 202
LEU A 203
 None
MG  A 386 (-2.5A)
None
None
 0.87A 5w3jB-3i6eA:
3.7		 5w3jB-3i6eA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_2
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 4 VAL A  40
LEU A  18
LEU A  20
ASP A 338
 None
 1.27A 5xv7A-3i6eA:
undetectable		 5xv7A-3i6eA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 6 GLU A  51
ARG A 120
ASP A 116
ASP A 364
 None
 1.25A 5zw4A-3i6eA:
undetectable		 5zw4A-3i6eA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 7 ALA A  72
GLU A 105
LYS A 107
LEU A 110
 None
 1.06A 6ci6A-3i6eA:
undetectable		 6ci6A-3i6eA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 6 ASP A 249
TYR A 298
GLU A 327
ASP A 301
 MG  A 386 (-3.1A)
None
None
None
 1.24A 6mn5A-3i6eA:
undetectable		 6mn5A-3i6eA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 6 ASP A 301
TYR A 298
GLU A 224
ASP A 198
 None
None
MG  A 386 (-2.7A)
MG  A 386 (-2.5A)
 1.47A 6mn5A-3i6eA:
undetectable		 6mn5A-3i6eA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 3i6e MUCONATE
CYCLOISOMERASE I
(Ruegeria
pomeroyi) 		4 / 6 ASP A 249
TYR A 298
GLU A 327
ASP A 301
 MG  A 386 (-3.1A)
None
None
None
 1.21A 6mn5C-3i6eA:
undetectable		 6mn5C-3i6eA:
12.87