SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i6r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_E_TRPE81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 6 THR A 249
SER A 345
THR A 348
ILE A 321
 FMN  A1002 (-3.8A)
ORO  A1003 (-3.2A)
None
None
 0.89A 1gtnD-3i6rA:
undetectable
1gtnE-3i6rA:
undetectable		 1gtnD-3i6rA:
10.60
1gtnE-3i6rA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 6 ASN A 274
ASN A 342
ASN A 458
THR A 459
 ORO  A1003 ( 3.1A)
ORO  A1003 ( 3.5A)
ORO  A1003 ( 3.0A)
ORO  A1003 (-2.6A)
 0.41A 1h7xA-3i6rA:
8.3		 1h7xA-3i6rA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 6 ASN A 274
ASN A 342
ASN A 458
THR A 459
 ORO  A1003 ( 3.1A)
ORO  A1003 ( 3.5A)
ORO  A1003 ( 3.0A)
ORO  A1003 (-2.6A)
 0.43A 1h7xB-3i6rA:
31.4		 1h7xB-3i6rA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 6 ASN A 274
ASN A 342
ASN A 458
THR A 459
 ORO  A1003 ( 3.1A)
ORO  A1003 ( 3.5A)
ORO  A1003 ( 3.0A)
ORO  A1003 (-2.6A)
 0.42A 1h7xC-3i6rA:
31.4		 1h7xC-3i6rA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 6 ASN A 274
ASN A 342
ASN A 458
THR A 459
 ORO  A1003 ( 3.1A)
ORO  A1003 ( 3.5A)
ORO  A1003 ( 3.0A)
ORO  A1003 (-2.6A)
 0.43A 1h7xD-3i6rA:
4.7		 1h7xD-3i6rA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_B_TRPB81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 8 THR A 348
ILE A 321
THR A 249
SER A 345
 None
None
FMN  A1002 (-3.8A)
ORO  A1003 (-3.2A)
 0.79A 1utdB-3i6rA:
undetectable
1utdC-3i6rA:
undetectable		 1utdB-3i6rA:
10.60
1utdC-3i6rA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 7 LEU A 515
GLY A 511
LEU A 550
PRO A 220
 None
 0.87A 1ya4B-3i6rA:
undetectable		 1ya4B-3i6rA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 8 ILE A 542
SER A 510
ASP A 513
LEU A 527
 None
 0.67A 2cdqA-3i6rA:
undetectable		 2cdqA-3i6rA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 6 VAL A 426
THR A 420
ASP A 337
PRO A 424
 None
 1.28A 2hdnJ-3i6rA:
2.5
2hdnK-3i6rA:
undetectable
2hdnL-3i6rA:
2.2		 2hdnJ-3i6rA:
21.70
2hdnK-3i6rA:
7.65
2hdnL-3i6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 5 GLN A 526
PHE A 244
PHE A 217
GLY A 453
 None
 1.24A 2qmzA-3i6rA:
undetectable
2qmzB-3i6rA:
undetectable		 2qmzA-3i6rA:
19.15
2qmzB-3i6rA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 10 GLY A 222
ILE A 307
ASP A 337
LEU A 238
PHE A 293
 None
 1.23A 3ay0B-3i6rA:
undetectable		 3ay0B-3i6rA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 7 VAL A 322
LYS A 326
ILE A 329
GLY A 333
 None
 0.73A 3bjwB-3i6rA:
undetectable		 3bjwB-3i6rA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_3
(PHOSPHOLIPASE A2)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 7 VAL A 322
LYS A 326
ILE A 329
GLY A 333
 None
 0.68A 3bjwF-3i6rA:
undetectable		 3bjwF-3i6rA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 7 VAL A 322
LYS A 326
ILE A 329
GLY A 333
 None
 0.82A 3bjwH-3i6rA:
undetectable		 3bjwH-3i6rA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 ILE A 455
VAL A 223
GLN A 526
PHE A 227
ILE A 234
 None
None
None
J5Z  A1001 (-4.4A)
None
 1.25A 3iw1A-3i6rA:
undetectable		 3iw1A-3i6rA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 GLU A 370
VAL A 343
ASP A 324
ILE A 321
ASN A 320
 None
 1.38A 3jayA-3i6rA:
undetectable		 3jayA-3i6rA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 LEU A 176
SER A 468
PHE A 469
GLY A 478
SER A 529
 J5Z  A1001 ( 4.3A)
None
None
FMN  A1002 (-3.7A)
FMN  A1002 (-2.3A)
 1.24A 3kk6B-3i6rA:
undetectable		 3kk6B-3i6rA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA277_0
(UNIVERSAL STRESS
PROTEIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		3 / 3 ASP A 200
SER A 202
ARG A 544
 None
 0.67A 3loqA-3i6rA:
undetectable		 3loqA-3i6rA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDT_B_VORB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		6 / 11 LEU A 430
PHE A 488
SER A 457
ILE A 442
ALA A 443
THR A 496
 None
 1.37A 3mdtB-3i6rA:
undetectable		 3mdtB-3i6rA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 10 PRO A 424
ILE A 329
VAL A 367
TYR A 338
ILE A 341
 None
 0.99A 3p4wD-3i6rA:
undetectable		 3p4wD-3i6rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 10 PRO A 424
ILE A 329
VAL A 367
TYR A 338
ILE A 341
 None
 0.99A 3p4wE-3i6rA:
undetectable		 3p4wE-3i6rA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 11 ILE A 307
PHE A 427
TYR A 338
GLU A 246
ILE A 455
 None
 1.19A 3q5rA-3i6rA:
undetectable		 3q5rA-3i6rA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_A_PAUA301_0
(TYPE III
PANTOTHENATE KINASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 LEU A 290
ASP A 337
ILE A 245
GLN A 297
LEU A 238
 None
 1.16A 4o5fA-3i6rA:
undetectable
4o5fB-3i6rA:
undetectable		 4o5fA-3i6rA:
21.74
4o5fB-3i6rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O5F_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 GLN A 297
LEU A 238
LEU A 290
ASP A 337
ILE A 245
 None
 1.15A 4o5fA-3i6rA:
undetectable
4o5fB-3i6rA:
undetectable		 4o5fA-3i6rA:
21.74
4o5fB-3i6rA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_1
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		3 / 3 ASP A 433
ASN A 435
SER A 485
 None
 0.71A 4obwA-3i6rA:
undetectable		 4obwA-3i6rA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 LEU A 531
GLY A 192
CYH A 233
LEU A 240
SER A 538
 J5Z  A1001 (-4.4A)
None
None
None
None
 1.50A 4ot2A-3i6rA:
undetectable		 4ot2A-3i6rA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_A_NOVA2000_1
(DNA GYRASE SUBUNIT B)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 ASN A 373
GLU A 375
ILE A 371
PRO A 424
ILE A 329
 None
 1.24A 4uroA-3i6rA:
undetectable		 4uroA-3i6rA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4URO_B_NOVB2000_1
(DNA GYRASE SUBUNIT B)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 ASN A 373
GLU A 375
ILE A 371
PRO A 424
ILE A 329
 None
 1.25A 4uroB-3i6rA:
undetectable		 4uroB-3i6rA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_A_PAUA302_0
(TYPE III
PANTOTHENATE KINASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 LEU A 290
ASP A 337
ILE A 245
GLN A 297
LEU A 238
 None
 1.13A 5b8hA-3i6rA:
undetectable
5b8hB-3i6rA:
undetectable		 5b8hA-3i6rA:
20.66
5b8hB-3i6rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B8H_B_PAUB302_0
(TYPE III
PANTOTHENATE KINASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 GLN A 297
LEU A 238
LEU A 290
ASP A 337
ILE A 245
 None
 1.18A 5b8hA-3i6rA:
undetectable
5b8hB-3i6rA:
undetectable		 5b8hA-3i6rA:
20.66
5b8hB-3i6rA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 HIS A 185
LEU A 187
GLY A 192
GLY A 241
PHE A 227
 J5Z  A1001 (-4.0A)
None
None
None
J5Z  A1001 (-4.4A)
 1.00A 5d4uA-3i6rA:
undetectable		 5d4uA-3i6rA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_3_BEZ3801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 4 LEU A 481
ILE A 463
GLY A 478
ILE A 466
 FMN  A1002 ( 4.9A)
None
FMN  A1002 (-3.7A)
None
 0.87A 5dzk3-3i6rA:
undetectable
5dzkm-3i6rA:
1.7		 5dzk3-3i6rA:
3.03
5dzkm-3i6rA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_W_BEZW801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 5 ILE A 463
GLY A 478
ILE A 466
LEU A 481
 None
FMN  A1002 (-3.7A)
None
FMN  A1002 ( 4.9A)
 0.81A 5dzkB-3i6rA:
undetectable
5dzkI-3i6rA:
undetectable
5dzkW-3i6rA:
undetectable		 5dzkB-3i6rA:
18.34
5dzkI-3i6rA:
18.45
5dzkW-3i6rA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_X_BEZX801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 5 ILE A 463
GLY A 478
ILE A 466
LEU A 481
 None
FMN  A1002 (-3.7A)
None
FMN  A1002 ( 4.9A)
 0.87A 5dzki-3i6rA:
undetectable
5dzkj-3i6rA:
undetectable
5dzkx-3i6rA:
undetectable		 5dzki-3i6rA:
18.45
5dzkj-3i6rA:
18.45
5dzkx-3i6rA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Z_BEZZ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 4 ILE A 463
GLY A 478
ILE A 466
LEU A 481
 None
FMN  A1002 (-3.7A)
None
FMN  A1002 ( 4.9A)
 0.77A 5dzkl-3i6rA:
2.2
5dzkz-3i6rA:
undetectable		 5dzkl-3i6rA:
18.45
5dzkz-3i6rA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 GLY A 521
PHE A 221
ALA A 514
ILE A 455
PHE A 427
 None
 1.19A 5ih0A-3i6rA:
undetectable		 5ih0A-3i6rA:
25.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K9D_A_CE9A402_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 HIS A 185
LEU A 187
PHE A 227
TYR A 528
LEU A 531
 J5Z  A1001 (-4.0A)
None
J5Z  A1001 (-4.4A)
FMN  A1002 (-3.9A)
J5Z  A1001 (-4.4A)
 1.08A 5k9dA-3i6rA:
52.9		 5k9dA-3i6rA:
37.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		3 / 3 THR A 251
PRO A 349
ARG A 352
 None
 0.71A 5nd7B-3i6rA:
3.2		 5nd7B-3i6rA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 GLY A 277
GLY A 226
VAL A 532
PHE A 533
ILE A 272
 ORO  A1003 (-3.4A)
FMN  A1002 (-3.0A)
J5Z  A1001 (-4.2A)
None
FMN  A1002 ( 4.1A)
 0.85A 5vimA-3i6rA:
undetectable		 5vimA-3i6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_0
(METHYLTRANSFERASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 GLY A 277
GLY A 226
VAL A 532
PHE A 533
ILE A 272
 ORO  A1003 (-3.4A)
FMN  A1002 (-3.0A)
J5Z  A1001 (-4.2A)
None
FMN  A1002 ( 4.1A)
 0.88A 5vimB-3i6rA:
undetectable		 5vimB-3i6rA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_B_CVIB301_1
(REGULATORY PROTEIN
TETR)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 8 GLY A 192
ARG A 296
ASP A 235
ASP A 228
 None
 0.93A 5vlmB-3i6rA:
undetectable		 5vlmB-3i6rA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_B_PA1B204_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		3 / 3 GLY A 231
ASN A 289
ARG A 296
 None
 0.75A 5w7bD-3i6rA:
undetectable		 5w7bD-3i6rA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		3 / 3 LYS A 429
ASN A 342
SER A 345
 FMN  A1002 (-2.8A)
ORO  A1003 ( 3.5A)
ORO  A1003 (-3.2A)
 1.24A 5yw0A-3i6rA:
undetectable		 5yw0A-3i6rA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 VAL A 476
SER A 477
PHE A 533
LEU A 176
VAL A 532
 None
FMN  A1002 (-3.0A)
None
J5Z  A1001 ( 4.3A)
J5Z  A1001 (-4.2A)
 1.33A 6a93B-3i6rA:
undetectable		 6a93B-3i6rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 7 ALA A 561
ILE A 542
LEU A 546
ILE A 503
 None
 0.80A 6b5vA-3i6rA:
undetectable
6b5vB-3i6rA:
undetectable		 6b5vA-3i6rA:
11.44
6b5vB-3i6rA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DHB_A_BEZA202_0
(HEPATITIS A VIRUS
CELLULAR RECEPTOR 2)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 6 PHE A 293
ARG A 296
ILE A 245
ASP A 235
 None
 1.38A 6dhbA-3i6rA:
undetectable		 6dhbA-3i6rA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLO_A_GBQA1501_1
(SUBSTANCE-P
RECEPTOR,GLGA
GLYCOGEN
SYNTHASE,SUBSTANCE-P
RECEPTOR)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 9 ASN A 195
ILE A 237
ILE A 234
VAL A 223
ILE A 245
 None
 1.34A 6hloA-3i6rA:
undetectable		 6hloA-3i6rA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		4 / 7 ILE A 272
GLU A 182
HIS A 185
VAL A 532
 FMN  A1002 ( 4.1A)
None
J5Z  A1001 (-4.0A)
J5Z  A1001 (-4.2A)
 1.11A 6j20A-3i6rA:
undetectable		 6j20A-3i6rA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QXS_B_FOZB403_0
(THYMIDYLATE SYNTHASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 12 LEU A 215
ILE A 307
PHE A 217
ASN A 219
ILE A 245
 None
 1.08A 6qxsB-3i6rA:
undetectable		 6qxsB-3i6rA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_B_FFOB403_0
(THYMIDYLATE SYNTHASE)		 3i6r DIHYDROOROTATE
DEHYDROGENASE
HOMOLOG,
MITOCHONDRIAL
(Plasmodium
falciparum) 		5 / 10 ILE A 250
ASN A 279
ASP A 228
GLY A 231
ASN A 289
 None
 1.41A 6r2eB-3i6rA:
undetectable		 6r2eB-3i6rA:
21.85