SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i6s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G60_B_SAMB501_0
(ADENINE-SPECIFIC
METHYLTRANSFERASE
MBOIIA)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 ASN A 317
ASP A 500
ILE A 332
PRO A 330
GLY A 328
 None
 1.13A 1g60B-3i6sA:
undetectable		 1g60B-3i6sA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 7 GLY A 441
PRO A 440
SER A 360
ALA A 364
 None
 0.96A 1gxsA-3i6sA:
undetectable
1gxsB-3i6sA:
undetectable		 1gxsA-3i6sA:
17.00
1gxsB-3i6sA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.29A 1q23B-3i6sA:
undetectable		 1q23B-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.29A 1q23C-3i6sA:
undetectable		 1q23C-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 11 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.36A 1q23F-3i6sA:
undetectable		 1q23F-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 11 THR A 569
SER A 750
PHE A 657
PHE A 674
LEU A 707
 None
 1.47A 1q23G-3i6sA:
undetectable		 1q23G-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 11 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.32A 1q23I-3i6sA:
undetectable		 1q23I-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 11 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.30A 1q23J-3i6sA:
undetectable		 1q23J-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 11 THR A 569
SER A 750
PHE A 657
LEU A 707
VAL A 678
 None
 1.34A 1q23L-3i6sA:
undetectable		 1q23L-3i6sA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q8J_B_C2FB802_0
(5-METHYLTETRAHYDROFO
LATE S-HOMOCYSTEINE
METHYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 ASN A 189
GLY A 168
ASN A 192
ILE A 204
GLY A 173
 None
 1.16A 1q8jB-3i6sA:
2.2		 1q8jB-3i6sA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QOM_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		3 / 3 ARG A 165
ILE A 162
TRP A 166
 None
 1.12A 1qomA-3i6sA:
undetectable		 1qomA-3i6sA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_B_DESB459_2
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		3 / 3 LEU A 527
HIS A 233
ILE A 532
 None
 0.52A 1s9pB-3i6sA:
undetectable		 1s9pB-3i6sA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 9 ILE A 414
ILE A 398
GLY A 441
ALA A 422
THR A 397
 None
 1.12A 2dtjA-3i6sA:
undetectable
2dtjB-3i6sA:
undetectable		 2dtjA-3i6sA:
14.66
2dtjB-3i6sA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_A_SAMA201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 4 PRO A 616
ASP A 618
ASP A 651
ASP A 613
 None
 1.31A 2nyuA-3i6sA:
2.0		 2nyuA-3i6sA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 11 LEU A 350
VAL A 452
ILE A 466
VAL A 444
ILE A 425
 None
 0.99A 2uxoB-3i6sA:
1.0		 2uxoB-3i6sA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_B_ACTB1463_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 7 VAL A 252
ILE A 147
ALA A 209
GLY A 187
 None
 0.78A 2xrzB-3i6sA:
undetectable		 2xrzB-3i6sA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB6_0
(FERROCHELATASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 LEU A 660
LEU A 494
ILE A 722
SER A 490
PRO A 330
 None
 1.13A 3aqiB-3i6sA:
undetectable		 3aqiB-3i6sA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		3 / 3 GLY A 405
ASP A 403
SER A 426
 None
 0.72A 3brfA-3i6sA:
undetectable		 3brfA-3i6sA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA152_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		3 / 3 VAL A 678
LYS A 715
HIS A 555
 None
 0.93A 3elzA-3i6sA:
undetectable		 3elzA-3i6sA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 4 LEU A 292
MET A 305
ILE A 658
ASP A 651
 None
 1.41A 3hecA-3i6sA:
undetectable		 3hecA-3i6sA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_A_MIYA2001_1
(TETX2 PROTEIN)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 11 PHE A 302
GLY A 303
SER A 640
PRO A 616
ASN A 621
 None
 1.22A 3v3nA-3i6sA:
undetectable		 3v3nA-3i6sA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 8 SER A 698
ASN A 697
THR A 754
GLY A 735
 None
 0.94A 4fo4A-3i6sA:
undetectable		 4fo4A-3i6sA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		6 / 12 ILE A 374
VAL A 373
ILE A 466
GLY A 441
ALA A 421
LEU A 419
 None
 1.46A 4o1zA-3i6sA:
undetectable		 4o1zA-3i6sA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 4 GLY A 173
LEU A 185
PHE A 154
ILE A 147
 None
 0.96A 4xv2A-3i6sA:
undetectable		 4xv2A-3i6sA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 ILE A 297
ALA A 300
ARG A 638
MET A 270
ALA A 268
 None
 1.22A 4zo1X-3i6sA:
undetectable		 4zo1X-3i6sA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 GLY A 505
GLY A 338
ALA A 336
ALA A 541
ALA A 478
 None
 1.20A 5bw4B-3i6sA:
undetectable		 5bw4B-3i6sA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_A_ACTA202_0
(NITROGEN REGULATORY
PROTEIN P-II)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 4 VAL A 278
GLY A 277
ARG A 165
VAL A 138
 None
 1.22A 5d4nA-3i6sA:
undetectable
5d4nB-3i6sA:
1.8		 5d4nA-3i6sA:
10.17
5d4nB-3i6sA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_B_SAMB401_0
(PAVINE
N-METHYLTRANSFERASE)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 SER A 221
GLY A 214
GLY A 216
VAL A 516
ALA A 511
 None
 1.12A 5kpcB-3i6sA:
undetectable		 5kpcB-3i6sA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		5 / 12 CYH A 219
ALA A 510
GLY A 243
ILE A 532
ASP A 213
 None
 1.03A 5wwsB-3i6sA:
undetectable		 5wwsB-3i6sA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 8 PRO A 504
ALA A 510
THR A 113
THR A 116
 None
 0.86A 5x2tI-3i6sA:
undetectable
5x2tJ-3i6sA:
undetectable
5x2tK-3i6sA:
undetectable
5x2tL-3i6sA:
undetectable		 5x2tI-3i6sA:
13.23
5x2tJ-3i6sA:
12.78
5x2tK-3i6sA:
13.23
5x2tL-3i6sA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 5 MET A 595
ASN A 327
VAL A 335
LEU A 502
 None
 1.50A 5xdhB-3i6sA:
undetectable		 5xdhB-3i6sA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 5 MET A 595
ASN A 327
VAL A 335
LEU A 502
 None
 1.40A 5xdhD-3i6sA:
undetectable		 5xdhD-3i6sA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 5 ASP A 402
ILE A 414
ASN A 454
TYR A 375
 None
 1.13A 6a93B-3i6sA:
undetectable		 6a93B-3i6sA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 4 VAL A 442
ALA A 421
PHE A 437
PHE A 362
 None
 1.42A 6cbdA-3i6sA:
2.5		 6cbdA-3i6sA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 3i6s SUBTILISIN-LIKE
PROTEASE
(Solanum
lycopersicum) 		4 / 7 ILE A 356
GLN A 451
VAL A 452
THR A 463
 None
 1.00A 6cduF-3i6sA:
undetectable
6cduG-3i6sA:
undetectable		 6cduF-3i6sA:
20.10
6cduG-3i6sA:
20.10