SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 GLY A  56
THR A 113
MET A  55
GLY A 117
TYR A 134
 None
 1.23A 1nbiC-3i6vA:
undetectable		 1nbiC-3i6vA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 GLY A  56
THR A 113
MET A  55
GLY A 117
TYR A 134
 None
 1.23A 1nbiD-3i6vA:
undetectable		 1nbiD-3i6vA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 GLU A 191
ILE A 154
PHE A 177
ALA A 156
 None
 1.10A 3pgyA-3i6vA:
undetectable
3pgyB-3i6vA:
undetectable		 3pgyA-3i6vA:
22.60
3pgyB-3i6vA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 10 ILE A 258
ALA A 267
PHE A 262
SER A 119
TYR A 269
 None
None
None
LYS  A   1 (-2.8A)
None
 1.42A 3qg2A-3i6vA:
undetectable		 3qg2A-3i6vA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA604_1
(TRANSPORTER)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 7 ILE A 258
PHE A  76
LEU A 254
THR A 131
 None
 1.10A 4mmcA-3i6vA:
undetectable		 4mmcA-3i6vA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 GLY A  75
PHE A  76
THR A  57
ILE A 114
GLY A 117
 None
 1.21A 4n48A-3i6vA:
undetectable		 4n48A-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 GLY A 239
PHE A 241
ILE A 120
THR A 121
GLY A 229
 None
None
GOL  A 280 (-4.6A)
None
None
 0.97A 4n48A-3i6vA:
undetectable		 4n48A-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		5 / 12 GLY A  75
PHE A  76
THR A  57
ILE A 114
GLY A 117
 None
 1.24A 4n48B-3i6vA:
undetectable		 4n48B-3i6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_G_377G401_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 GLU A  77
TYR A 134
LEU A 254
PHE A  76
 None
 1.34A 4twdF-3i6vA:
undetectable
4twdG-3i6vA:
undetectable		 4twdF-3i6vA:
19.17
4twdG-3i6vA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0I_B_ACTB303_0
(SWI5-DEPENDENT HO
EXPRESSION PROTEIN 2)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 5 VAL A  53
THR A 113
ASP A 234
LEU A 237
 None
 1.33A 5m0iB-3i6vA:
undetectable		 5m0iB-3i6vA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 6 LEU A 106
GLY A 109
ARG A 231
ARG A  54
 None
 0.85A 6gtqB-3i6vA:
undetectable
6gtqD-3i6vA:
undetectable		 6gtqB-3i6vA:
24.78
6gtqD-3i6vA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 3i6v PERIPLASMIC
HIS/GLU/GLN/ARG/OPIN
E FAMILY-BINDING
PROTEIN
(Ruegeria
pomeroyi) 		4 / 7 ALA A 116
GLY A 117
GLY A  81
ASN A  65
 None
 0.85A 6nm4A-3i6vA:
undetectable		 6nm4A-3i6vA:
22.31