SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i6y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 11 LEU A 247
HIS A 273
HIS A 269
PHE A 272
GLY A 146
 None
 1.18A 1zz1A-3i6yA:
undetectable		 1zz1A-3i6yA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_B_SHHB2552_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 12 LEU A 247
HIS A 273
HIS A 269
PHE A 272
GLY A 146
 None
 1.17A 1zz1B-3i6yA:
undetectable
1zz1C-3i6yA:
undetectable		 1zz1B-3i6yA:
21.78
1zz1C-3i6yA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8L_A_SAMA400_0
(HYPOTHETICAL PROTEIN
LMO1582)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 12 ALA A  92
GLY A 100
ASP A  94
LEU A  99
PRO A 113
 None
 1.09A 2f8lA-3i6yA:
undetectable		 2f8lA-3i6yA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 12 LEU A  55
ILE A 174
GLN A 230
ASP A  98
LEU A 191
 CL  A 280 (-3.6A)
None
None
None
None
 1.08A 2jn3A-3i6yA:
undetectable		 2jn3A-3i6yA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		4 / 8 PHE A 171
GLY A 146
LEU A 155
PRO A 173
 None
 1.15A 3bgdB-3i6yA:
undetectable		 3bgdB-3i6yA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 12 PRO A 129
ASN A 108
ILE A 132
TYR A  50
ILE A 157
 None
 1.34A 3q5pA-3i6yA:
undetectable		 3q5pA-3i6yA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 11 PRO A 129
ASN A 108
ILE A 132
TYR A  50
ILE A 157
 None
 1.37A 3q5rA-3i6yA:
undetectable		 3q5rA-3i6yA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R0L_D_ACTD127_0
(PHOSPHOLIPASE A2 CB)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		4 / 5 PHE A 171
ILE A 262
GLY A 146
HIS A 269
 None
 1.03A 3r0lD-3i6yA:
undetectable		 3r0lD-3i6yA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		4 / 7 TRP A 182
GLY A 150
GLY A 151
ASN A 175
 None
 1.01A 4fgkB-3i6yA:
undetectable		 4fgkB-3i6yA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QLE_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 11 LEU A   6
LYS A  17
SER A   2
ILE A   3
TYR A 123
 None
 1.12A 4qleB-3i6yA:
undetectable		 4qleB-3i6yA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HGC_A_HCYA501_1
(SERPIN)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 12 VAL A  46
PRO A  47
ALA A  78
ILE A 132
PHE A 136
 None
 1.37A 5hgcA-3i6yA:
undetectable		 5hgcA-3i6yA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TZO_B_7V7B201_1
(ENDO-1,4-BETA-XYLANA
SE A)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 12 LEU A 249
SER A 148
ALA A 145
ALA A 170
GLY A 151
 None
CL  A 280 (-3.0A)
None
None
None
 1.16A 5tzoB-3i6yA:
undetectable		 5tzoB-3i6yA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V5Z_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 3i6y ESTERASE APC40077
(Oleispira
antarctica) 		5 / 12 TYR A  97
PHE A 105
GLY A 183
HIS A 147
MET A 149
 None
 1.42A 5v5zA-3i6yA:
undetectable		 5v5zA-3i6yA:
19.42