SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i7a'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_1
(DIHYDROFOLATE
REDUCTASE)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 12 LEU A 151
ALA A 202
SER A 223
LEU A 132
ALA A 152
 None
 1.01A 1ao8A-3i7aA:
undetectable		 1ao8A-3i7aA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		4 / 8 PHE A 227
TYR A 135
ASP A 226
GLY A 255
 None
 0.82A 1ekjE-3i7aA:
undetectable
1ekjF-3i7aA:
undetectable		 1ekjE-3i7aA:
24.92
1ekjF-3i7aA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 10 LEU A  20
LEU A  11
ILE A 191
ILE A 177
LEU A 183
 None
 1.16A 1wopA-3i7aA:
undetectable		 1wopA-3i7aA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		4 / 7 SER A 121
THR A 120
VAL A 117
TRP A 212
 None
 0.97A 2uz2A-3i7aA:
undetectable		 2uz2A-3i7aA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		4 / 4 TYR A 135
LEU A 131
LEU A 256
HIS A 139
 None
 1.47A 2x7hB-3i7aA:
undetectable		 2x7hB-3i7aA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRL_A_DXTA1211_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 12 SER A 198
PHE A 201
PRO A  26
LEU A 161
ILE A 158
 None
 1.35A 2xrlA-3i7aA:
1.5		 2xrlA-3i7aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 12 LEU A  87
ILE A  85
TYR A  69
GLN A  89
THR A  88
 None
 1.44A 3elzC-3i7aA:
undetectable		 3elzC-3i7aA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		4 / 8 TYR A 234
PHE A 268
SER A 265
ILE A 134
 None
 1.06A 3jz0B-3i7aA:
undetectable		 3jz0B-3i7aA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGH_C_FLPC701_1
(CYCLOOXYGENASE-2)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		6 / 12 VAL A 113
LEU A  11
LEU A 180
GLY A 159
ALA A 160
LEU A 164
 None
 1.48A 3pghC-3i7aA:
0.3		 3pghC-3i7aA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VLN_A_ACTA908_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		4 / 4 MET A 114
SER A 105
LEU A 164
VAL A 110
 None
 1.28A 3vlnA-3i7aA:
1.0		 3vlnA-3i7aA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AFT_D_QMRD301_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		4 / 8 TRP A 212
VAL A 209
VAL A 205
ILE A 228
 None
 1.10A 4aftD-3i7aA:
undetectable
4aftE-3i7aA:
undetectable		 4aftD-3i7aA:
22.57
4aftE-3i7aA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_A_IBPA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 10 VAL A 113
LEU A 180
GLY A 159
ALA A 160
LEU A 164
 None
 1.11A 4ph9A-3i7aA:
undetectable		 4ph9A-3i7aA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PH9_B_IBPB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 10 VAL A 113
LEU A 180
GLY A 159
ALA A 160
LEU A 164
 None
 1.11A 4ph9B-3i7aA:
0.0		 4ph9B-3i7aA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 12 ALA A 126
GLN A 133
ILE A  93
VAL A  63
ILE A  85
 None
 1.09A 4uw0A-3i7aA:
undetectable		 4uw0A-3i7aA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 12 VAL A 113
LEU A  11
GLY A 159
ALA A 160
LEU A 164
 None
 1.27A 5iktB-3i7aA:
undetectable		 5iktB-3i7aA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		3 / 3 ASN A 145
TYR A 224
CYH A 129
 None
 0.88A 5lsuB-3i7aA:
undetectable		 5lsuB-3i7aA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 12 ILE A  61
ALA A  75
ILE A  85
ALA A  64
VAL A  82
 None
 1.05A 5n0tB-3i7aA:
undetectable		 5n0tB-3i7aA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 10 VAL A  63
GLU A 100
LEU A 154
ILE A 122
THR A 125
 None
 1.38A 6d9hR-3i7aA:
undetectable		 6d9hR-3i7aA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HCO_A_FY5A1003_0
(ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2)		 3i7a PUTATIVE
METAL-DEPENDENT
PHOSPHOHYDROLASE
(Shewanella
amazonensis) 		5 / 11 ASN A 157
VAL A 205
THR A  95
ILE A 122
MET A  99
 None
 1.26A 6hcoA-3i7aA:
0.6
6hcoB-3i7aA:
undetectable		 6hcoA-3i7aA:
19.21
6hcoB-3i7aA:
19.21