SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i7f'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1002_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 PHE A 253
ILE A 514
VAL A 461
ILE A 433
LEU A 254
 None
 1.19A 1fm4A-3i7fA:
undetectable		 1fm4A-3i7fA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWF_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 9 LEU A  81
VAL A 140
VAL A  61
GLY A 119
LEU A  79
 None
 1.16A 1lwfA-3i7fA:
undetectable		 1lwfA-3i7fA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 LEU A 419
LEU A 422
ILE A 423
LEU A 389
LEU A 398
 None
 1.04A 1xdkB-3i7fA:
undetectable		 1xdkB-3i7fA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A68_C_RBTC8001_1
(DNA-DIRECTED RNA
POLYMERASE BETA
CHAIN
RNA POLYMERASE SIGMA
FACTOR RPOD)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 11 GLN A 375
PHE A 162
PRO A 527
ILE A 526
ASP A 230
 None
 1.17A 2a68C-3i7fA:
0.4
2a68F-3i7fA:
0.6		 2a68C-3i7fA:
20.23
2a68F-3i7fA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 6 ARG A 384
PHE A 386
PHE A 431
PHE A 354
 None
 1.39A 3af3A-3i7fA:
undetectable		 3af3A-3i7fA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOC_C_ERYC3402_0
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 SER A 470
MET A 350
ILE A 335
PHE A 354
GLU A 517
 None
 1.10A 3aocC-3i7fA:
undetectable		 3aocC-3i7fA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWC_A_SAMA501_0
(SPERMIDINE SYNTHASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 HIS A 326
ILE A 519
GLY A 515
VAL A 315
THR A 469
 None
 1.04A 3bwcA-3i7fA:
undetectable		 3bwcA-3i7fA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 11 LEU A 516
ILE A 468
GLY A 525
ILE A 526
ILE A 519
 None
 1.12A 3ebzA-3i7fA:
undetectable		 3ebzA-3i7fA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 7 GLU A 336
TYR A 445
TYR A 498
PHE A 502
 None
 1.29A 3ku9B-3i7fA:
undetectable		 3ku9B-3i7fA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_A_DSFA319_1
(GLR4197 PROTEIN)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 9 ILE A 239
ILE A 372
VAL A 532
TYR A 523
THR A 520
 None
 1.37A 3p4wA-3i7fA:
undetectable		 3p4wA-3i7fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 8 ILE A 468
ILE A 514
VAL A 463
ILE A 357
 None
 0.86A 3p4wC-3i7fA:
undetectable		 3p4wC-3i7fA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 6 ILE A 339
ASN A 342
GLU A 351
VAL A 461
 None
 1.06A 4ejwB-3i7fA:
1.3		 4ejwB-3i7fA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		4 / 5 PHE A 502
TYR A 498
THR A 446
PHE A 444
 None
 1.19A 4jx1E-3i7fA:
undetectable		 4jx1E-3i7fA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		3 / 3 ARG A  64
ASP A 116
TYR A  40
 None
 0.76A 4yo9B-3i7fA:
undetectable		 4yo9B-3i7fA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 10 ILE A 239
ILE A 372
VAL A 532
TYR A 523
THR A 520
 None
 1.25A 5mzrA-3i7fA:
undetectable		 5mzrA-3i7fA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 10 ILE A 239
ILE A 372
VAL A 532
TYR A 523
THR A 520
 None
 1.26A 5mzrC-3i7fA:
undetectable		 5mzrC-3i7fA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_D_PFLD410_1
(PROTON-GATED ION
CHANNEL)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 9 ILE A 239
ILE A 372
VAL A 532
TYR A 523
THR A 520
 None
 1.27A 5mzrD-3i7fA:
undetectable		 5mzrD-3i7fA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 ILE A 335
PHE A 354
TYR A 459
MET A 337
VAL A 349
 None
 1.16A 5n0rA-3i7fA:
undetectable		 5n0rA-3i7fA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 ILE A 335
PHE A 354
TYR A 459
MET A 337
VAL A 349
 None
 1.21A 5n0wA-3i7fA:
undetectable		 5n0wA-3i7fA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UAN_B_REAB503_1
(RETINOIC ACID
RECEPTOR BETA)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 ALA A 400
LEU A 419
LEU A 422
ILE A 423
LEU A 389
 None
 1.13A 5uanB-3i7fA:
undetectable		 5uanB-3i7fA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 10 HIS A 326
GLU A 467
GLY A 515
ARG A 518
ILE A 529
 None
 1.22A 6bniA-3i7fA:
26.5		 6bniA-3i7fA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_A_ADNA602_1
(LYSINE--TRNA LIGASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 10 HIS A 326
PHE A 330
GLU A 467
GLY A 515
ILE A 529
 None
 0.93A 6bniA-3i7fA:
26.5		 6bniA-3i7fA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 10 HIS A 326
GLU A 467
GLY A 515
ARG A 518
ILE A 529
 None
 1.21A 6bniB-3i7fA:
26.6		 6bniB-3i7fA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BNI_B_ADNB602_1
(LYSINE--TRNA LIGASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 10 HIS A 326
PHE A 330
GLU A 467
GLY A 515
ILE A 529
 None
 0.92A 6bniB-3i7fA:
26.6		 6bniB-3i7fA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 3i7f ASPARTYL-TRNA
SYNTHETASE
(Entamoeba
histolytica) 		5 / 12 LEU A 369
ILE A 372
ILE A  85
ILE A 361
ILE A 242
 None
 0.93A 6emuA-3i7fA:
undetectable		 6emuA-3i7fA:
15.51