SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i7j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		4 / 6 ASN A 198
HIS A 213
GLY A 193
TYR A 192
 None
 1.14A 1c8lA-3i7jA:
undetectable		 1c8lA-3i7jA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JIN_A_KTNA801_1
(CYTOCHROME P450
107A1)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		5 / 11 SER A  70
VAL A  59
ALA A  53
ALA A  49
LEU A 202
 None
 1.06A 1jinA-3i7jA:
undetectable		 1jinA-3i7jA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OLT_A_SAMA502_0
(OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		5 / 9 HIS A 226
GLY A 203
PHE A 119
LEU A 163
ILE A 234
 None
 1.31A 1oltA-3i7jA:
0.0		 1oltA-3i7jA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_A_SALA506_1
(SALICYLATE
SYNTHETASE, IRP9)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		5 / 11 ILE A 234
THR A 178
HIS A 174
ARG A  48
GLY A 225
 None
 1.32A 2fn1A-3i7jA:
undetectable		 2fn1A-3i7jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FN1_B_SALB503_1
(SALICYLATE
SYNTHETASE, IRP9)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		5 / 11 ILE A 234
THR A 178
HIS A 174
ARG A  48
GLY A 225
 None
 1.32A 2fn1B-3i7jA:
undetectable		 2fn1B-3i7jA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_D_ACTD36_0
(GCN4 LEUCINE ZIPPER)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		3 / 3 SER A  86
TYR A 102
HIS A  85
 None
 0.82A 2r2vD-3i7jA:
undetectable		 2r2vD-3i7jA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_M_TFPM201_1
(PROTEIN S100-A4)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		4 / 7 GLY A  81
PHE A 204
GLY A 103
PHE A 104
 None
 0.97A 3ko0M-3i7jA:
undetectable
3ko0P-3i7jA:
undetectable		 3ko0M-3i7jA:
15.71
3ko0P-3i7jA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_D_ACTD502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		3 / 3 GLY A 103
THR A 105
ASN A 101
 None
 0.71A 3v4tD-3i7jA:
undetectable		 3v4tD-3i7jA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVC_B_HFGB1602_0
(BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		5 / 12 LEU A  61
VAL A  54
HIS A  78
THR A  42
GLY A 146
 None
 1.34A 4hvcB-3i7jA:
undetectable		 4hvcB-3i7jA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		4 / 8 GLY A 216
THR A 223
LEU A 242
ASN A 219
 None
 1.02A 4m5mA-3i7jA:
undetectable		 4m5mA-3i7jA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		5 / 12 GLY A 253
PHE A 227
ILE A 263
GLY A 232
GLY A 231
 None
 0.92A 5koxA-3i7jA:
undetectable		 5koxA-3i7jA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 3i7j BETA-LACTAMASE
MB2281C
(Mycobacterium
bovis) 		4 / 8 TYR A 122
PHE A 119
VAL A  59
SER A 115
 None
 1.19A 6huoC-3i7jA:
undetectable
6huoD-3i7jA:
undetectable		 6huoC-3i7jA:
15.42
6huoD-3i7jA:
16.29