SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i7u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_B_T44B128_1
(TRANSTHYRETIN)		 3i7u AP4A HYDROLASE
(Aquifex
aeolicus) 		4 / 6 LYS A  81
GLU A  64
ALA A   7
THR A  43
 None
 1.02A 2roxB-3i7uA:
undetectable		 2roxB-3i7uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 3i7u AP4A HYDROLASE
(Aquifex
aeolicus) 		4 / 6 GLU A  91
PRO A  94
ARG A  93
GLY A  90
 None
 1.27A 3oxvA-3i7uA:
undetectable		 3oxvA-3i7uA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 3i7u AP4A HYDROLASE
(Aquifex
aeolicus) 		3 / 3 GLU A  51
TRP A  96
ASN A  33
 None
None
CL  A 148 ( 4.4A)
 1.10A 5dv4A-3i7uA:
undetectable		 5dv4A-3i7uA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_A_SAMA601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 3i7u AP4A HYDROLASE
(Aquifex
aeolicus) 		5 / 12 GLY A  53
LYS A  21
LYS A  99
LEU A 112
PHE A 104
 None
 1.17A 5ybbA-3i7uA:
undetectable		 5ybbA-3i7uA:
13.51