SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i83'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_A_EAAA211_1
(GLUTATHIONE
S-TRANSFERASE)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 7 PHE A 127
ILE A  11
TYR A  15
GLY A 144
 None
 0.86A 11gsA-3i83A:
undetectable		 11gsA-3i83A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
11GS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 7 PHE A 127
GLY A 129
ILE A  11
TYR A  15
GLY A 144
 None
 1.19A 11gsB-3i83A:
undetectable		 11gsB-3i83A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 12 PHE A 166
LEU A 162
ALA A 165
ILE A  42
ILE A   3
 None
 1.10A 1crbA-3i83A:
undetectable		 1crbA-3i83A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 8 PHE A 127
ILE A  11
TYR A  15
GLY A 144
 None
 0.87A 2gssA-3i83A:
undetectable		 2gssA-3i83A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 8 PHE A 127
ILE A  11
TYR A  15
GLY A 144
 None
 0.86A 2gssB-3i83A:
undetectable		 2gssB-3i83A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 12 VAL A   5
GLY A   9
ALA A  20
VAL A  28
GLY A  12
 None
 0.84A 2v0zO-3i83A:
undetectable		 2v0zO-3i83A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 9 PHE A 127
GLY A 129
ILE A  11
TYR A  15
GLY A 144
 None
 1.19A 3csjB-3i83A:
undetectable		 3csjB-3i83A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 12 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.07A 3ln1A-3i83A:
undetectable		 3ln1A-3i83A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 12 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.07A 3ln1B-3i83A:
undetectable		 3ln1B-3i83A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 12 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.08A 3ln1D-3i83A:
undetectable		 3ln1D-3i83A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 8 PHE A 127
ILE A  11
TYR A  15
GLY A 144
 None
 0.94A 3n9jA-3i83A:
undetectable		 3n9jA-3i83A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 8 TYR A 293
VAL A 292
ILE A 219
GLU A 300
 None
 0.84A 4a97D-3i83A:
2.7		 4a97D-3i83A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 11 SER A 156
ALA A 163
LEU A 148
GLY A 149
ILE A 138
 None
 1.06A 4kt0A-3i83A:
undetectable
4kt0J-3i83A:
undetectable		 4kt0A-3i83A:
18.65
4kt0J-3i83A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 8 SER A 156
ALA A 163
LEU A 148
GLY A 149
 None
 0.73A 4xk8a-3i83A:
undetectable		 4xk8a-3i83A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 12 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.03A 5jw1A-3i83A:
undetectable		 5jw1A-3i83A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		5 / 12 GLN A 264
VAL A  80
GLY A  82
ALA A  83
LEU A  88
 None
 1.04A 5jw1B-3i83A:
undetectable		 5jw1B-3i83A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_B_PFLB510_1
(PROTON-GATED ION
CHANNEL)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 6 ILE A   6
ALA A  92
LEU A  89
ILE A  99
 None
 0.76A 5mvmB-3i83A:
undetectable
5mvmC-3i83A:
undetectable		 5mvmB-3i83A:
13.82
5mvmC-3i83A:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW5_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 3i83 2-DEHYDROPANTOATE
2-REDUCTASE
(Methylococcus
capsulatus) 		4 / 8 GLY A 149
LEU A 148
GLU A 177
ALA A 175
 None
 0.73A 5vw5A-3i83A:
undetectable		 5vw5A-3i83A:
22.60