SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		4 / 5 LEU A 132
ASP A  32
GLY A 115
ALA A 143
 None
 0.96A 2aohA-3i8oA:
undetectable		 2aohA-3i8oA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A  35
SER A 135
ARG A  40
LEU A  44
 None
None
ACT  A 168 ( 4.1A)
None
 1.14A 2f78A-3i8oA:
2.1		 2f78A-3i8oA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_B_BEZB1004_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		4 / 7 VAL A  35
SER A 135
ARG A  40
LEU A  44
 None
None
ACT  A 168 ( 4.1A)
None
 1.18A 2f78B-3i8oA:
undetectable		 2f78B-3i8oA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1001_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		4 / 6 VAL A  35
SER A 135
ARG A  40
LEU A  44
 None
None
ACT  A 168 ( 4.1A)
None
 1.15A 2f8dA-3i8oA:
undetectable		 2f8dA-3i8oA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A 130
LEU A  86
LEU A  50
ILE A  57
PRO A  58
 None
 1.43A 6dlzB-3i8oA:
undetectable
6dlzC-3i8oA:
2.5		 6dlzB-3i8oA:
20.14
6dlzC-3i8oA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  57
PRO A  58
SER A 130
LEU A  86
LEU A  50
 None
 1.43A 6dlzA-3i8oA:
2.5
6dlzD-3i8oA:
2.6		 6dlzA-3i8oA:
20.14
6dlzD-3i8oA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		5 / 10 SER A 130
LEU A  86
LEU A  50
ILE A  57
PRO A  58
 None
 1.43A 6dm1B-3i8oA:
undetectable
6dm1C-3i8oA:
2.4		 6dm1B-3i8oA:
20.14
6dm1C-3i8oA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 3i8o KH DOMAIN-CONTAINING
PROTEIN MJ1533
(Methanocaldococc
us
jannaschii) 		5 / 11 ILE A  57
PRO A  58
SER A 130
LEU A  86
LEU A  50
 None
 1.43A 6dm1A-3i8oA:
2.4
6dm1D-3i8oA:
2.6		 6dm1A-3i8oA:
20.14
6dm1D-3i8oA:
20.14