SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i8t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i8t GALECTIN-4
(Mus
musculus) 		3 / 3 VAL A  72
ALA A  73
HIS A 138
 None
None
GOL  A 166 ( 4.7A)
 0.70A 1q23H-3i8tA:
undetectable		 1q23H-3i8tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3i8t GALECTIN-4
(Mus
musculus) 		3 / 3 VAL A  72
ALA A  73
HIS A 138
 None
None
GOL  A 166 ( 4.7A)
 0.66A 1q23J-3i8tA:
undetectable		 1q23J-3i8tA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VPT_A_SAMA400_0
(VP39)		 3i8t GALECTIN-4
(Mus
musculus) 		5 / 12 ILE A  47
GLY A 130
VAL A  60
VAL A  45
LEU A 148
 None
 0.98A 1vptA-3i8tA:
undetectable		 1vptA-3i8tA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_D_KLND1499_1
(CYTOCHROME P450 3A4)		 3i8t GALECTIN-4
(Mus
musculus) 		4 / 5 PHE A  88
PHE A  58
PHE A 133
ILE A 159
 None
 1.08A 2v0mD-3i8tA:
undetectable		 2v0mD-3i8tA:
16.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_A_1GNA998_1
(GALECTIN-7)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 6 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.25A 3galA-3i8tA:
24.2		 3galA-3i8tA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GAL_B_1GNB999_1
(GALECTIN-7)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 6 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.35A 3galB-3i8tA:
24.2		 3galB-3i8tA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 3i8t GALECTIN-4
(Mus
musculus) 		4 / 8 HIS A  75
ASN A  77
HIS A  59
GLY A 152
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
GOL  A 167 (-3.8A)
GOL  A 167 ( 3.7A)
 0.87A 5m8rC-3i8tA:
undetectable		 5m8rC-3i8tA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6B8K_A_W9TA300_0
(GALECTIN-3)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 7 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.20A 6b8kA-3i8tA:
24.4		 6b8kA-3i8tA:
34.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_A_W9TA201_0
(GALECTIN-1)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 8 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.39A 6b94A-3i8tA:
19.4		 6b94A-3i8tA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B94_B_W9TB201_0
(GALECTIN-1)		 3i8t GALECTIN-4
(Mus
musculus) 		6 / 10 HIS A  75
ASN A  77
ARG A  79
ASN A  89
TRP A  96
GLU A  99
 LBT  A 165 (-4.0A)
GOL  A 167 ( 3.2A)
LBT  A 165 (-2.6A)
LBT  A 165 (-3.8A)
LBT  A 165 ( 3.6A)
LBT  A 165 (-3.0A)
 0.37A 6b94A-3i8tA:
19.4
6b94B-3i8tA:
19.0		 6b94A-3i8tA:
24.49
6b94B-3i8tA:
24.49