SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Z2P_B_DOLB2003_1 (VIRGINIAMYCIN B LYASE)	3i8z	E3 SUMO-PROTEIN LIGASE CBX4 (Homo sapiens)	5 / 10	PRO A 37 ASN A 40 GLU A 17 SER A 15 GLU A 14	None	1.47A	2z2pA-3i8zA: undetectable 2z2pB-3i8zA: undetectable	2z2pA-3i8zA: 9.40 2z2pB-3i8zA: 9.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4X3U_B_SVRB101_1 (CHROMOBOX PROTEIN HOMOLOG 7)	3i8z	E3 SUMO-PROTEIN LIGASE CBX4 (Homo sapiens)	6 / 9	ARG A 20 LEU A 29 TRP A 32 TYR A 39 THR A 41 TRP A 42	None	0.60A	4x3uA-3i8zA: 4.9	4x3uA-3i8zA: 73.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4X3U_B_SVRB101_2 (CHROMOBOX PROTEIN HOMOLOG 7)	3i8z	E3 SUMO-PROTEIN LIGASE CBX4 (Homo sapiens)	6 / 10	ARG A 20 LEU A 29 TRP A 32 TYR A 39 THR A 41 TRP A 42	None	0.92A	4x3uB-3i8zA: 5.3	4x3uB-3i8zA: 73.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4X3U_B_SVRB101_2 (CHROMOBOX PROTEIN HOMOLOG 7)	3i8z	E3 SUMO-PROTEIN LIGASE CBX4 (Homo sapiens)	6 / 10	ARG A 20 TRP A 32 TRP A 35 TYR A 39 THR A 41 TRP A 42	None	1.05A	4x3uB-3i8zA: 5.3	4x3uB-3i8zA: 73.21

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2Z2P_B_DOLB2003_1","VIRGINIAMYCIN B LYASE;VIRGINIAMYCIN B LYASE","3i8z","E3 SUMO-PROTEIN LIGASE CBX4","Homo sapiens",5,"PRO A  37;ASN A  40;GLU A  17;SER A  15;GLU A  14","None","1.47A","2z2pA-3i8zA:undetectable;2z2pB-3i8zA:undetectable","2z2pA-3i8zA:9.40;2z2pB-3i8zA:9.40"],["4X3U_B_SVRB101_1","CHROMOBOX PROTEIN HOMOLOG 7;CHROMOBOX PROTEIN HOMOLOG 7","3i8z","E3 SUMO-PROTEIN LIGASE CBX4","Homo sapiens",6,"ARG A  20;LEU A  29;TRP A  32;TYR A  39;THR A  41;TRP A  42","None","0.60A","4x3uA-3i8zA:4.9","4x3uA-3i8zA:73.21"],["4X3U_B_SVRB101_2","CHROMOBOX PROTEIN HOMOLOG 7","3i8z","E3 SUMO-PROTEIN LIGASE CBX4","Homo sapiens",6,"ARG A  20;LEU A  29;TRP A  32;TYR A  39;THR A  41;TRP A  42","None","0.92A","4x3uB-3i8zA:5.3","4x3uB-3i8zA:73.21"],["4X3U_B_SVRB101_2","CHROMOBOX PROTEIN HOMOLOG 7","3i8z","E3 SUMO-PROTEIN LIGASE CBX4","Homo sapiens",6,"ARG A  20;TRP A  32;TRP A  35;TYR A  39;THR A  41;TRP A  42","None","1.05A","4x3uB-3i8zA:5.3","4x3uB-3i8zA:73.21"]]