SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3i9u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JWJ_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 4 MET A  34
ARG A 136
ILE A 211
PHE A 214
 HEM  A 300 (-3.8A)
DTU  A2001 (-3.1A)
None
HEM  A 300 (-4.5A)
 1.33A 1jwjA-3i9uA:
0.0		 1jwjA-3i9uA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JWJ_B_H4BB902_1
(NITRIC OXIDE
SYNTHASE)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 4 MET A  34
ARG A 136
ILE A 211
PHE A 214
 HEM  A 300 (-3.8A)
DTU  A2001 (-3.1A)
None
HEM  A 300 (-4.5A)
 1.32A 1jwjB-3i9uA:
0.0		 1jwjB-3i9uA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ1_A_HLTA2001_1
(FERRITIN LIGHT CHAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 4 LEU A  54
SER A  53
TYR A  55
LEU A  89
 None
 1.19A 1xz1A-3i9uA:
4.2		 1xz1A-3i9uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZ3_A_ICFA201_1
(FERRITIN LIGHT CHAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 4 LEU A  54
SER A  53
TYR A  55
LEU A  89
 None
 1.19A 1xz3A-3i9uA:
4.3		 1xz3A-3i9uA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZR_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.26A 1zzrA-3i9uA:
undetectable
1zzrB-3i9uA:
undetectable		 1zzrA-3i9uA:
20.37
1zzrB-3i9uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_H4BA760_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.23A 1zzuA-3i9uA:
undetectable
1zzuB-3i9uA:
undetectable		 1zzuA-3i9uA:
20.37
1zzuB-3i9uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_H4BB761_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 GLU A 190
VAL A  73
ARG A 198
VAL A 130
 None
 1.26A 1zzuA-3i9uA:
undetectable
1zzuB-3i9uA:
undetectable		 1zzuA-3i9uA:
20.37
1zzuB-3i9uA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_0
(ESTROGEN RECEPTOR)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		5 / 12 LEU A 128
LEU A  77
LEU A  13
LEU A 189
LEU A  17
 None
 1.06A 2ouzA-3i9uA:
2.7		 2ouzA-3i9uA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 6 HIS A 132
THR A 135
LEU A 118
LEU A  61
 None
HEM  A 300 (-4.8A)
None
None
 1.00A 3bgdA-3i9uA:
undetectable		 3bgdA-3i9uA:
25.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IIZ_A_SAMA1501_0
(BIOTIN SYNTHETASE,
PUTATIVE)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		5 / 12 TYR A  58
SER A 142
GLY A 144
ILE A  65
LEU A  83
 None
HEM  A 300 (-3.8A)
DTU  A2001 (-3.9A)
None
None
 1.15A 3iizA-3i9uA:
undetectable		 3iizA-3i9uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.28A 3jx3A-3i9uA:
undetectable
3jx3B-3i9uA:
undetectable		 3jx3A-3i9uA:
20.51
3jx3B-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX5_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.26A 3jx5A-3i9uA:
undetectable
3jx5B-3i9uA:
undetectable		 3jx5A-3i9uA:
20.51
3jx5B-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLQ_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 GLU A 190
VAL A  73
ARG A 198
VAL A 130
 None
 1.23A 3nlqA-3i9uA:
undetectable
3nlqB-3i9uA:
undetectable		 3nlqA-3i9uA:
20.51
3nlqB-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NLR_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.26A 3nlrA-3i9uA:
undetectable
3nlrB-3i9uA:
undetectable		 3nlrA-3i9uA:
20.51
3nlrB-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 8 ALA A 133
LEU A  77
ASP A 140
TYR A 182
 None
None
DTU  A2001 (-4.5A)
None
 0.94A 3qj7A-3i9uA:
undetectable
3qj7D-3i9uA:
undetectable		 3qj7A-3i9uA:
20.95
3qj7D-3i9uA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		3 / 3 PRO A 109
THR A 108
LEU A 213
 None
 0.73A 3ttrA-3i9uA:
undetectable		 3ttrA-3i9uA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.25A 4cx3A-3i9uA:
undetectable
4cx3B-3i9uA:
undetectable		 4cx3A-3i9uA:
20.51
4cx3B-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX3_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 GLU A 190
VAL A  73
ARG A 198
VAL A 130
 None
 1.28A 4cx3A-3i9uA:
undetectable
4cx3B-3i9uA:
undetectable		 4cx3A-3i9uA:
20.51
4cx3B-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.27A 4cx4A-3i9uA:
undetectable
4cx4B-3i9uA:
undetectable		 4cx4A-3i9uA:
20.51
4cx4B-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX4_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 GLU A 190
VAL A  73
ARG A 198
VAL A 130
 None
 1.31A 4cx4A-3i9uA:
undetectable
4cx4B-3i9uA:
undetectable		 4cx4A-3i9uA:
20.51
4cx4B-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 6 PHE A  47
SER A  53
ALA A  52
LEU A  49
 None
 1.10A 5dzkB-3i9uA:
undetectable
5dzkP-3i9uA:
undetectable		 5dzkB-3i9uA:
26.20
5dzkP-3i9uA:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 PHE A  47
SER A  53
ALA A  52
LEU A  49
 None
 1.08A 5dzkD-3i9uA:
undetectable
5dzkR-3i9uA:
undetectable		 5dzkD-3i9uA:
26.20
5dzkR-3i9uA:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 VAL A  73
ARG A 198
VAL A 130
GLU A 190
 None
 1.30A 5g0pA-3i9uA:
undetectable
5g0pB-3i9uA:
undetectable		 5g0pA-3i9uA:
20.51
5g0pB-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G0P_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 7 GLU A 190
VAL A  73
ARG A 198
VAL A 130
 None
 1.33A 5g0pA-3i9uA:
undetectable
5g0pB-3i9uA:
undetectable		 5g0pA-3i9uA:
20.51
5g0pB-3i9uA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFP_A_8W5A804_2
(GLUCOCORTICOID
RECEPTOR)		 3i9u HEME OXYGENASE 1
(Rattus
norvegicus) 		4 / 4 LEU A 181
MET A 186
ILE A 172
LEU A 138
 None
None
None
HEM  A 300 ( 4.5A)
 1.28A 5nfpA-3i9uA:
undetectable		 5nfpA-3i9uA:
21.03