SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ia7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EPB_A_9CRA165_2
(EPIDIDYMAL RETINOIC
ACID-BINDING PROTEIN)		 3ia7 CALG4
(Micromonospora
echinospora) 		4 / 7 LEU A 294
ALA A 297
VAL A 232
VAL A 263
 None
 0.87A 1epbA-3ia7A:
undetectable		 1epbA-3ia7A:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WU8_C_ADNC502_1
(HYPOTHETICAL PROTEIN
PH0463)		 3ia7 CALG4
(Micromonospora
echinospora) 		4 / 7 PHE A 112
TYR A 180
ARG A 128
VAL A 177
 None
None
CL  A 403 (-4.8A)
None
 1.41A 1wu8A-3ia7A:
undetectable
1wu8C-3ia7A:
undetectable		 1wu8A-3ia7A:
22.72
1wu8C-3ia7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3ia7 CALG4
(Micromonospora
echinospora) 		5 / 11 THR A 302
LEU A 321
VAL A 336
GLY A 342
VAL A 372
 None
 1.27A 2a1nA-3ia7A:
undetectable		 2a1nA-3ia7A:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LOQ_A_ACTA278_0
(UNIVERSAL STRESS
PROTEIN)		 3ia7 CALG4
(Micromonospora
echinospora) 		3 / 3 SER A 382
GLY A 211
SER A 195
 None
 0.63A 3loqA-3ia7A:
4.2		 3loqA-3ia7A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QG2_B_CP6B709_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 3ia7 CALG4
(Micromonospora
echinospora) 		5 / 11 ILE A  34
ALA A  49
PHE A   8
ILE A 189
LEU A  27
 None
 1.20A 3qg2B-3ia7A:
undetectable		 3qg2B-3ia7A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9V_B_DXCB1_0
(INVASIN IPAD)		 3ia7 CALG4
(Micromonospora
echinospora) 		4 / 7 SER A 354
LEU A 350
VAL A 320
SER A 343
 None
 0.90A 3r9vA-3ia7A:
undetectable
3r9vB-3ia7A:
undetectable		 3r9vA-3ia7A:
20.83
3r9vB-3ia7A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 3ia7 CALG4
(Micromonospora
echinospora) 		5 / 12 ILE A 189
GLY A 131
PHE A 191
LYS A 194
ALA A 135
 None
None
None
None
CL  A 403 (-4.3A)
 1.10A 4eb4A-3ia7A:
undetectable		 4eb4A-3ia7A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB810_1
(CATALASE-PEROXIDASE)		 3ia7 CALG4
(Micromonospora
echinospora) 		4 / 6 ARG A 356
TRP A 260
LEU A 301
SER A 354
 None
 1.50A 5syjB-3ia7A:
undetectable		 5syjB-3ia7A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3ia7 CALG4
(Micromonospora
echinospora) 		3 / 3 PHE A   8
ASP A 108
LEU A  41
 None
 0.69A 5uhbC-3ia7A:
undetectable		 5uhbC-3ia7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 3ia7 CALG4
(Micromonospora
echinospora) 		3 / 3 PHE A   8
ASP A 108
LEU A  41
 None
 0.64A 5uhcC-3ia7A:
undetectable		 5uhcC-3ia7A:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ia7 CALG4
(Micromonospora
echinospora) 		3 / 3 GLU A 179
TYR A 180
ARG A 116
 None
 0.67A 5uunA-3ia7A:
undetectable		 5uunA-3ia7A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 3ia7 CALG4
(Micromonospora
echinospora) 		3 / 3 GLU A 179
TYR A 180
ARG A 116
 None
 0.76A 5uunB-3ia7A:
undetectable		 5uunB-3ia7A:
20.39