SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iab'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.89A 1p7lD-3iabA:
undetectable		 1p7lD-3iabA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.90A 1p7lC-3iabA:
undetectable		 1p7lC-3iabA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.88A 1rg9B-3iabA:
undetectable		 1rg9B-3iabA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.88A 1rg9A-3iabA:
undetectable		 1rg9A-3iabA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.88A 1rg9D-3iabA:
undetectable		 1rg9D-3iabA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.90A 1rg9C-3iabA:
undetectable		 1rg9C-3iabA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_1
(PUTATIVE RRNA
METHYLASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 105
ASP A 144
GLN A  77
 None
 0.78A 3eeyC-3iabA:
5.2		 3eeyC-3iabA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_D_SAMD300_1
(PUTATIVE RRNA
METHYLASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 105
ASP A 144
GLN A  77
 None
 0.78A 3eeyD-3iabA:
5.2		 3eeyD-3iabA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_1
(PUTATIVE RRNA
METHYLASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 105
ASP A 144
GLN A  77
 None
 0.77A 3eeyE-3iabA:
5.0		 3eeyE-3iabA:
24.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_A_SAMA500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP7
(Saccharomyces
cerevisiae) 		5 / 12 GLY B  67
ALA B  71
SER B  43
HIS B  81
PHE B  82
 A  R  91 ( 3.2A)
A  R  91 ( 3.7A)
U  R  89 ( 2.8A)
None
None
 1.43A 4bupA-3iabB:
undetectable		 4bupA-3iabB:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.84A 4kttD-3iabA:
undetectable		 4kttD-3iabA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP7
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 ILE B 138
ALA B  64
THR A 156
PRO A 136
ILE B  90
 None
 0.91A 4p3qA-3iabB:
undetectable		 4p3qA-3iabB:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZ8_A_GCSA208_1
(GLUCANASE/CHITOSANAS
E)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP7
(Saccharomyces
cerevisiae) 		4 / 7 GLU B  91
TYR B 139
GLU B 135
TYR B  62
 None
 1.13A 4zz8A-3iabB:
undetectable		 4zz8A-3iabB:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP6
(Saccharomyces
cerevisiae) 		4 / 8 GLU A 131
ASP A 119
ILE A 120
ILE A  16
 A  R  71 ( 4.0A)
None
None
None
 0.92A 5t8sA-3iabA:
undetectable		 5t8sA-3iabA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP7
(Saccharomyces
cerevisiae) 		5 / 12 GLY B  67
ALA B  71
SER B  43
HIS B  81
PHE B  82
 A  R  91 ( 3.2A)
A  R  91 ( 3.7A)
U  R  89 ( 2.8A)
None
None
 1.25A 5wbvA-3iabB:
undetectable		 5wbvA-3iabB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 3iab RIBONUCLEASES P/MRP
PROTEIN SUBUNIT POP7
(Saccharomyces
cerevisiae) 		5 / 12 GLY B  67
ALA B  71
SER B  43
HIS B  81
PHE B  82
 A  R  91 ( 3.2A)
A  R  91 ( 3.7A)
U  R  89 ( 2.8A)
None
None
 1.27A 5wbvB-3iabB:
undetectable		 5wbvB-3iabB:
22.27