SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iah'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 11 LEU A  16
LEU A 139
LEU A 131
LEU A 135
MET A 175
 None
 1.33A 1mx1B-3iahA:
3.6		 1mx1B-3iahA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 11 LEU A  16
LEU A 139
LEU A 188
LEU A 131
LEU A 135
 None
 1.28A 1mx1B-3iahA:
3.6		 1mx1B-3iahA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 12 GLY A  19
ARG A  44
ASP A  70
ASN A  99
ALA A 100
 NAP  A 254 (-3.2A)
NAP  A 254 (-3.6A)
NAP  A 254 (-3.7A)
NAP  A 254 (-3.3A)
NAP  A 254 (-3.8A)
 1.02A 2bm9E-3iahA:
5.6		 2bm9E-3iahA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		3 / 3 LEU A  97
LEU A 179
MET A 176
 None
 0.85A 2itzA-3iahA:
undetectable		 2itzA-3iahA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		4 / 6 THR A  68
ASP A  70
THR A  73
ASP A 119
 None
NAP  A 254 (-3.7A)
None
None
 1.28A 2okcB-3iahA:
5.2		 2okcB-3iahA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OUZ_A_C3DA999_1
(ESTROGEN RECEPTOR)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		4 / 6 ALA A 219
ASP A 220
GLU A  27
ARG A  26
 None
 1.40A 2ouzA-3iahA:
undetectable		 2ouzA-3iahA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		4 / 7 TYR A  32
GLY A  19
ALA A  20
LEU A  41
 None
NAP  A 254 (-3.2A)
None
None
 0.94A 2wekB-3iahA:
8.2		 2wekB-3iahA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 12 GLY A  25
LEU A  30
ASP A  22
LEU A  41
LEU A  49
 None
None
NAP  A 254 (-4.4A)
None
None
 0.96A 2yqzA-3iahA:
8.1		 2yqzA-3iahA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 12 GLY A  25
LEU A  30
ASP A  22
LEU A  41
LEU A  49
 None
None
NAP  A 254 (-4.4A)
None
None
 0.96A 2yqzB-3iahA:
7.6		 2yqzB-3iahA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		4 / 5 SER A 233
ARG A 189
ARG A  92
GLY A  95
 None
 1.22A 3k9fA-3iahA:
undetectable
3k9fB-3iahA:
undetectable
3k9fC-3iahA:
undetectable		 3k9fA-3iahA:
19.29
3k9fB-3iahA:
19.29
3k9fC-3iahA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_2
(ADENOSINE KINASE)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		4 / 5 SER A 152
ILE A  24
TYR A 165
GLY A 196
 ACT  A 255 (-2.6A)
NAP  A 254 (-3.9A)
ACT  A 255 ( 4.3A)
NAP  A 254 (-4.6A)
 0.85A 3uboB-3iahA:
5.6		 3uboB-3iahA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		3 / 3 ARG A  13
ARG A 189
ASP A 232
 None
 1.00A 3wipG-3iahA:
undetectable
3wipH-3iahA:
undetectable		 3wipG-3iahA:
20.36
3wipH-3iahA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		3 / 3 ARG A 203
PHE A 207
PRO A 208
 EOH  A 257 (-3.3A)
ACT  A 256 ( 4.9A)
None
 0.62A 3zoaB-3iahA:
undetectable		 3zoaB-3iahA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		4 / 5 GLY A 197
GLY A 196
ASN A 194
GLU A 210
 NAP  A 254 (-3.3A)
NAP  A 254 (-4.6A)
None
None
 1.07A 4fglC-3iahA:
6.8		 4fglC-3iahA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_B_SFYB806_0
(SEPIAPTERIN
REDUCTASE)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 11 LEU A 103
SER A 152
TYR A 165
MET A 202
ALA A 206
 None
ACT  A 255 (-2.6A)
ACT  A 255 ( 4.3A)
NAP  A 254 (-3.6A)
ACT  A 255 ( 4.0A)
 0.44A 4hwkB-3iahA:
27.1		 4hwkB-3iahA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_C_SFYC804_0
(SEPIAPTERIN
REDUCTASE)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 12 LEU A 103
SER A 152
TYR A 165
MET A 202
ALA A 206
 None
ACT  A 255 (-2.6A)
ACT  A 255 ( 4.3A)
NAP  A 254 (-3.6A)
ACT  A 255 ( 4.0A)
 0.47A 4hwkC-3iahA:
27.1		 4hwkC-3iahA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HWK_D_SFYD803_0
(SEPIAPTERIN
REDUCTASE)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		5 / 11 LEU A 103
SER A 152
TYR A 165
MET A 202
ALA A 206
 None
ACT  A 255 (-2.6A)
ACT  A 255 ( 4.3A)
NAP  A 254 (-3.6A)
ACT  A 255 ( 4.0A)
 0.49A 4hwkD-3iahA:
27.1		 4hwkD-3iahA:
28.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 3iah SHORT CHAIN
DEHYDROGENASE YCIK
(Salmonella
enterica) 		4 / 5 SER A 142
ARG A  13
ASP A 143
ARG A 234
 None
 1.34A 6dwdA-3iahA:
undetectable		 6dwdA-3iahA:
18.93