SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3iay'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 VAL A 970
ILE A 973
GLU A 860
LEU A 819
 None
 0.94A 1j96B-3iayA:
undetectable		 1j96B-3iayA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 THR A 791
SER A 790
LEU A 607
VAL A 768
PHE A 770
 None
 1.45A 1q23K-3iayA:
undetectable		 1q23K-3iayA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T3R_A_017A1200_1
(PROTEASE RETROPEPSIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.77A 1t3rA-3iayA:
undetectable		 1t3rA-3iayA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7I_A_017A200_1
(POL POLYPROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.80A 1t7iA-3iayA:
undetectable		 1t7iA-3iayA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VQ1_A_SAMA301_1
(N5-GLUTAMINE
METHYLTRANSFERASE,
HEMK)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 GLY A 930
ASP A 953
ASN A 932
 None
 0.65A 1vq1A-3iayA:
undetectable		 1vq1A-3iayA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 942
PRO A 902
ILE A 884
ILE A 928
VAL A 945
 None
 1.11A 1z9hD-3iayA:
2.6		 1z9hD-3iayA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 PRO A 942
PRO A 902
ILE A 884
TYR A 957
VAL A 945
 None
 1.07A 1z9hD-3iayA:
2.6		 1z9hD-3iayA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.86A 2aquB-3iayA:
undetectable		 2aquB-3iayA:
7.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVO_B_MK1B902_2
(POL POLYPROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.81A 2avoB-3iayA:
undetectable		 2avoB-3iayA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_3
(POL POLYPROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.85A 2avvB-3iayA:
undetectable		 2avvB-3iayA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_2
(POL POLYPROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.91A 2f8gB-3iayA:
undetectable		 2f8gB-3iayA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.79A 2fxeB-3iayA:
undetectable		 2fxeB-3iayA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMY_A_ROCA401_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.80A 2nmyA-3iayA:
undetectable		 2nmyA-3iayA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.86A 2nmzA-3iayA:
undetectable		 2nmzA-3iayA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_3
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.79A 2nmzB-3iayA:
undetectable		 2nmzB-3iayA:
8.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.75A 2nnpA-3iayA:
undetectable		 2nnpA-3iayA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4K_A_DR7A301_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.87A 2o4kB-3iayA:
undetectable		 2o4kB-3iayA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q5K_A_AB1A201_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.95A 2q5kB-3iayA:
undetectable		 2q5kB-3iayA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.84A 2q63A-3iayA:
undetectable		 2q63A-3iayA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.78A 2q64B-3iayA:
undetectable		 2q64B-3iayA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.83A 2qakA-3iayA:
undetectable		 2qakA-3iayA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 712
GLY A 709
ILE A 723
VAL A 715
GLY A 716
 None
 0.87A 2qe6A-3iayA:
undetectable		 2qe6A-3iayA:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.90A 2r5pB-3iayA:
undetectable		 2r5pB-3iayA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 TYR A 805
TYR A 808
SER A 765
LYS A 803
 None
None
CA  A   2 ( 4.6A)
None
 0.85A 2vmyA-3iayA:
undetectable
2vmyB-3iayA:
undetectable		 2vmyA-3iayA:
18.42
2vmyB-3iayA:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 THR A 647
ARG A 732
GLU A 588
SER A 725
 None
 1.04A 2zw9A-3iayA:
undetectable		 2zw9A-3iayA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_B_CHDB1086_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 6A2
CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 GLY A 263
GLN A 117
THR A 255
ARG A 542
GLY A 545
 None
 1.14A 2zxwA-3iayA:
2.9
2zxwB-3iayA:
undetectable
2zxwT-3iayA:
undetectable		 2zxwA-3iayA:
19.30
2zxwB-3iayA:
12.17
2zxwT-3iayA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1X_A_ROCA201_1
(HIV-1 PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.75A 3d1xA-3iayA:
undetectable		 3d1xA-3iayA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Y_A_ROCA201_1
(HIV-1 PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.77A 3d1yA-3iayA:
undetectable		 3d1yA-3iayA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 ILE A 969
GLN A 963
ILE A 973
LEU A 958
 None
 1.34A 3dzyD-3iayA:
undetectable		 3dzyD-3iayA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_C_478C200_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.88A 3ekpD-3iayA:
undetectable		 3ekpD-3iayA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.76A 3ekqA-3iayA:
undetectable		 3ekqA-3iayA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL1_A_DR7A100_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.84A 3el1B-3iayA:
undetectable		 3el1B-3iayA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.81A 3el4A-3iayA:
undetectable		 3el4A-3iayA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.76A 3el9B-3iayA:
undetectable		 3el9B-3iayA:
7.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 400
ASP A 407
ILE A 408
GLN A 466
 None
CA  A   4 ( 4.2A)
None
None
 0.75A 3fi0E-3iayA:
undetectable		 3fi0E-3iayA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 400
ASP A 407
ILE A 408
GLN A 466
 None
CA  A   4 ( 4.2A)
None
None
 0.69A 3fi0G-3iayA:
undetectable		 3fi0G-3iayA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_I_TRPI1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 400
ASP A 407
ILE A 408
GLN A 466
 None
CA  A   4 ( 4.2A)
None
None
 0.73A 3fi0I-3iayA:
undetectable		 3fi0I-3iayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 GLY A 400
ASP A 407
ILE A 408
GLN A 466
 None
CA  A   4 ( 4.2A)
None
None
 0.66A 3fi0P-3iayA:
undetectable		 3fi0P-3iayA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_A_PNTA901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 926
SER A 847
VAL A 846
TYR A 956
ASN A 960
 None
 1.35A 3hiiA-3iayA:
2.2		 3hiiA-3iayA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HII_B_PNTB901_0
(AMILORIDE-SENSITIVE
AMINE OXIDASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 TYR A 926
SER A 847
VAL A 846
TYR A 956
ASN A 960
 None
 1.35A 3hiiB-3iayA:
1.8		 3hiiB-3iayA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 THR A 133
LYS A 199
GLU A 131
 None
 0.99A 3ijdB-3iayA:
undetectable		 3ijdB-3iayA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_1
(HIV-1 PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.82A 3k4vA-3iayA:
undetectable		 3k4vA-3iayA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_3
(HIV-1 PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.85A 3k4vB-3iayA:
undetectable		 3k4vB-3iayA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KD5_E_PPFE914_1
(DNA POLYMERASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 5 ASP A 608
LEU A 612
ARG A 674
LYS A 701
ASP A 764
 CA  A   3 ( 2.3A)
DCP  A 986 (-4.6A)
DCP  A 986 (-2.9A)
DCP  A 986 (-2.7A)
CA  A   2 (-2.8A)
 0.81A 3kd5E-3iayA:
23.3		 3kd5E-3iayA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_1
(HIV-1 PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.74A 3lzvA-3iayA:
undetectable		 3lzvA-3iayA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MJR_B_AC2B401_1
(DEOXYCYTIDINE KINASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 348
VAL A 142
GLN A 290
ARG A 428
ASP A 394
 None
 1.29A 3mjrB-3iayA:
0.1		 3mjrB-3iayA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.81A 3ndtA-3iayA:
undetectable		 3ndtA-3iayA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDT_A_ROCA101_3
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.87A 3ndtB-3iayA:
undetectable		 3ndtB-3iayA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.75A 3ndxB-3iayA:
undetectable		 3ndxB-3iayA:
8.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXW_D_017D200_1
(HIV-1 PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.82A 3oxwC-3iayA:
undetectable		 3oxwC-3iayA:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_A_RBFA190_2
(RIBOFLAVIN UPTAKE
PROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 4 TYR A 161
ASN A 225
ASN A 251
PHE A 565
 None
 1.48A 3p5nA-3iayA:
0.4		 3p5nA-3iayA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB1_0
(HEME-BINDING PROTEIN
HUTZ)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 TYR A 249
PHE A 213
PRO A 163
LEU A 211
 None
 1.36A 3tgvB-3iayA:
undetectable		 3tgvB-3iayA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_C_BEZC1_0
(HEME-BINDING PROTEIN
HUTZ)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 249
PHE A 213
PRO A 163
LEU A 211
 None
 1.25A 3tgvC-3iayA:
undetectable		 3tgvC-3iayA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKW_B_017B401_2
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.87A 3tkwB-3iayA:
undetectable		 3tkwB-3iayA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.80A 3tl9A-3iayA:
undetectable		 3tl9A-3iayA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 12 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.87A 3tl9B-3iayA:
undetectable		 3tl9B-3iayA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 227
PHE A 187
LEU A 183
PHE A 179
 None
 1.05A 3wg7C-3iayA:
2.5
3wg7J-3iayA:
undetectable		 3wg7C-3iayA:
13.74
3wg7J-3iayA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ALA A 785
PHE A 770
ALA A 605
LEU A 607
 None
 0.92A 4du2A-3iayA:
undetectable		 4du2A-3iayA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 257
VAL A 561
LEU A 564
SER A 562
 None
 1.35A 4e1gA-3iayA:
undetectable		 4e1gA-3iayA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 8 GLY A 661
ILE A 662
ILE A 571
THR A 625
 None
 0.85A 4em2A-3iayA:
undetectable		 4em2A-3iayA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ALA A 533
ILE A 399
VAL A 397
ALA A 349
ILE A 317
 None
 1.10A 4lbgB-3iayA:
undetectable		 4lbgB-3iayA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MV7_A_PPFA501_1
(BIOTIN CARBOXYLASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 ASN A 284
VAL A 286
GLU A 292
ARG A 138
 None
 1.30A 4mv7A-3iayA:
undetectable		 4mv7A-3iayA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 THR A 248
GLU A 232
THR A 246
LEU A 160
 None
 0.86A 4pgfA-3iayA:
undetectable		 4pgfA-3iayA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_1
(ASPARTYL PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.79A 4q1xA-3iayA:
undetectable		 4q1xA-3iayA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QGI_A_ROCA101_1
(PROTEASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 11 ASP A 976
GLY A 975
ALA A 971
ILE A 811
GLY A 598
 None
 0.81A 4qgiA-3iayA:
undetectable		 4qgiA-3iayA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YIA_B_IMNB401_1
(THYROXINE-BINDING
GLOBULIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 10 SER A 243
LEU A 160
LEU A 227
SER A 237
LEU A 236
 None
 1.15A 4yiaA-3iayA:
undetectable		 4yiaA-3iayA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HP1_C_PPFC601_1
(HIV-1 REVERSE
TRANSCRIPTASE P66
SUBUNIT)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LYS A 701
ARG A 674
ASP A 764
ASP A 608
 DCP  A 986 (-2.7A)
DCP  A 986 (-2.9A)
CA  A   2 (-2.8A)
CA  A   3 ( 2.3A)
 1.44A 5hp1C-3iayA:
4.8		 5hp1C-3iayA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 202
PRO A 576
VAL A 260
ILE A 252
LEU A 663
 None
 1.47A 5iepA-3iayA:
undetectable		 5iepA-3iayA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_2
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		3 / 3 VAL A 870
ARG A 597
PRO A 972
 None
 0.79A 5koxA-3iayA:
1.8		 5koxA-3iayA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPR_A_PAUA404_0
(PANTOTHENATE KINASE
3)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 GLY A 146
SER A 148
ARG A 428
GLY A 141
 None
 0.98A 5kprA-3iayA:
undetectable		 5kprA-3iayA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		6 / 12 ILE A 356
ILE A 368
VAL A 359
LEU A 518
PHE A 360
VAL A 345
 None
 1.38A 5mueA-3iayA:
undetectable		 5mueA-3iayA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 5 LEU A 227
PHE A 187
LEU A 183
PHE A 179
 None
 1.00A 5x19C-3iayA:
2.1
5x19J-3iayA:
undetectable		 5x19C-3iayA:
13.74
5x19J-3iayA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_P_CHDP304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 227
PHE A 187
LEU A 183
PHE A 179
 None
 0.98A 5x1fP-3iayA:
3.2
5x1fW-3iayA:
undetectable		 5x1fP-3iayA:
13.74
5x1fW-3iayA:
5.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 258
TYR A 254
VAL A 162
GLY A 155
 None
 1.02A 6hd4B-3iayA:
undetectable		 6hd4B-3iayA:
6.81