SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ib3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 LEU A 135
THR A 174
TRP A 138
TYR A  76
 None
None
None
PLM  A 563 (-4.5A)
 1.23A 1afsA-3ib3A:
undetectable		 1afsA-3ib3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 LEU A 135
THR A 174
TRP A 138
TYR A  76
 None
None
None
PLM  A 563 (-4.5A)
 1.23A 1afsB-3ib3A:
undetectable		 1afsB-3ib3A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DBB_H_STRH229_1
(IGG1-KAPPA DB3 FAB
(HEAVY CHAIN)
IGG1-KAPPA DB3 FAB
(LIGHT CHAIN))		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 GLY A 194
ASN A 196
TRP A 176
GLY A 277
 None
 0.91A 1dbbH-3ib3A:
undetectable
1dbbL-3ib3A:
undetectable		 1dbbH-3ib3A:
17.17
1dbbL-3ib3A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 TRP A 138
VAL A 178
TRP A 177
 None
 1.16A 1gmkC-3ib3A:
undetectable
1gmkD-3ib3A:
undetectable		 1gmkC-3ib3A:
3.23
1gmkD-3ib3A:
3.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_B_VIBB501_1
(THIAMIN
PYROPHOSPHOKINASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 GLN A 391
ASP A 392
SER A 516
SER A 386
 None
 1.25A 1ig3A-3ib3A:
undetectable
1ig3B-3ib3A:
2.4		 1ig3A-3ib3A:
17.47
1ig3B-3ib3A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7Q_A_BEZA600_0
(COCAINE ESTERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 TYR A  76
TYR A 170
HIS A 274
LEU A 273
PHE A 213
 PLM  A 563 (-4.5A)
None
None
None
None
 1.40A 1l7qA-3ib3A:
32.5		 1l7qA-3ib3A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7Q_A_BEZA600_0
(COCAINE ESTERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 TYR A  76
TYR A 170
TRP A 217
HIS A 274
PHE A 213
 PLM  A 563 (-4.5A)
None
None
None
None
 1.31A 1l7qA-3ib3A:
32.5		 1l7qA-3ib3A:
27.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 ALA A 143
GLU A 144
LEU A 181
ARG A  49
MET A  71
 None
 1.45A 1qkuA-3ib3A:
undetectable		 1qkuA-3ib3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 ALA A 143
GLU A 144
LEU A 181
ARG A  49
MET A  71
 None
 1.46A 1qkuB-3ib3A:
undetectable		 1qkuB-3ib3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 ALA A 143
GLU A 144
LEU A 181
ARG A  49
MET A  71
 None
 1.47A 1qkuC-3ib3A:
undetectable		 1qkuC-3ib3A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 TRP A 138
THR A 218
TYR A 214
 None
 1.08A 2a3aA-3ib3A:
undetectable		 2a3aA-3ib3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 TRP A 138
THR A 218
TYR A 214
 None
 1.04A 2a3aB-3ib3A:
undetectable		 2a3aB-3ib3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 TRP A 138
THR A 218
TYR A 214
 None
 1.07A 2a3bA-3ib3A:
undetectable		 2a3bA-3ib3A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_A_THAA400_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 PHE A 352
GLU A 280
GLN A 473
TYR A 359
 None
None
None
CL  A 561 (-4.9A)
 1.19A 2aoxA-3ib3A:
undetectable		 2aoxA-3ib3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOX_B_THAB401_1
(HISTAMINE
N-METHYLTRANSFERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 PHE A 352
GLU A 280
GLN A 473
TYR A 359
 None
None
None
CL  A 561 (-4.9A)
 1.20A 2aoxB-3ib3A:
1.6		 2aoxB-3ib3A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 SER A 136
GLU A 144
SER A 180
GLN A 257
 None
 1.25A 2cl5B-3ib3A:
undetectable		 2cl5B-3ib3A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 7 ARG A 297
GLU A 299
ASN A 275
ALA A 266
 None
 1.36A 2ejgA-3ib3A:
undetectable		 2ejgA-3ib3A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 ALA A  73
THR A 174
ALA A 188
ILE A 150
PHE A 316
 None
 1.03A 2nyrA-3ib3A:
undetectable		 2nyrA-3ib3A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCF_A_ESTA596_1
(ESTROGEN RECEPTOR)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 ALA A 143
GLU A 144
LEU A 181
ARG A  49
MET A  71
 None
 1.38A 2ocfA-3ib3A:
undetectable		 2ocfA-3ib3A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 6 SER A 136
GLU A 144
SER A 180
GLN A 257
 None
 1.17A 2zvjA-3ib3A:
undetectable		 2zvjA-3ib3A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 GLY A 281
GLY A 194
LEU A 195
PRO A 254
VAL A 173
 None
 1.06A 3av6A-3ib3A:
undetectable		 3av6A-3ib3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_3
(PHOSPHOLIPASE A2)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 VAL A 168
LEU A 171
GLY A 167
PRO A 108
THR A 103
 None
 1.14A 3bjwF-3ib3A:
undetectable		 3bjwF-3ib3A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_A_ADNA500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 243
GLU A 481
LYS A 483
ASP A 422
GLY A 206
 None
 1.42A 3ce6A-3ib3A:
3.7		 3ce6A-3ib3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CE6_C_ADNC500_1
(ADENOSYLHOMOCYSTEINA
SE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 243
GLU A 481
LYS A 483
ASP A 422
GLY A 206
 None
 1.43A 3ce6C-3ib3A:
3.7		 3ce6C-3ib3A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 TYR A 146
ALA A 153
ALA A 124
TYR A  55
 None
 1.26A 3d91A-3ib3A:
undetectable		 3d91A-3ib3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MEC_A_65BA561_0
(P66 REVERSE
TRANSCRIPTASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 TYR A 319
GLY A 164
TRP A 327
LEU A 263
PRO A 191
 None
 1.26A 3mecA-3ib3A:
undetectable		 3mecA-3ib3A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZMD_A_SALA201_1
(PUTATIVE
TRANSCRIPTIONAL
REGULATOR)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 8 ARG A 276
TYR A 199
GLU A 201
HIS A 478
 None
 1.34A 3zmdA-3ib3A:
undetectable
3zmdB-3ib3A:
undetectable		 3zmdA-3ib3A:
13.46
3zmdB-3ib3A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 4 ILE A  58
VAL A  70
VAL A 119
ARG A  60
 None
 1.23A 4m6tA-3ib3A:
undetectable		 4m6tA-3ib3A:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 ASN A  35
SER A  30
LEU A   5
ASN A 116
 None
 1.24A 4n09C-3ib3A:
3.1		 4n09C-3ib3A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 LEU A 186
ALA A 154
VAL A  69
THR A 165
ILE A 163
 None
 1.07A 4njuB-3ib3A:
undetectable		 4njuB-3ib3A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 10 LEU A 186
ALA A 154
VAL A  69
THR A 165
ILE A 163
 None
 1.07A 4njuD-3ib3A:
undetectable		 4njuD-3ib3A:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 11 ILE A 494
GLN A 473
ARG A 276
VAL A 513
LEU A 554
 None
 1.14A 4nqaA-3ib3A:
undetectable		 4nqaA-3ib3A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 496
GLU A 510
VAL A 511
GLU A 517
GLY A 521
 None
 1.25A 4q15B-3ib3A:
undetectable		 4q15B-3ib3A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YDQ_A_HFGA802_0
(PROLINE--TRNA LIGASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 496
GLU A 510
VAL A 511
GLU A 517
GLY A 521
 None
 1.27A 4ydqA-3ib3A:
2.2		 4ydqA-3ib3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_A_HFGA702_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 496
GLU A 510
VAL A 511
GLU A 517
GLY A 521
 None
 1.25A 5f9zA-3ib3A:
undetectable		 5f9zA-3ib3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F9Z_B_HFGB703_0
(AMINOACYL-TRNA
SYNTHETASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 496
GLU A 510
VAL A 511
GLU A 517
GLY A 521
 None
 1.26A 5f9zB-3ib3A:
2.1		 5f9zB-3ib3A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 5 SER A 136
GLU A 144
SER A 180
GLN A 257
 None
 1.24A 5fhrB-3ib3A:
2.3		 5fhrB-3ib3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HHJ_A_GLYA403_0
(RETRON-TYPE REVERSE
TRANSCRIPTASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		4 / 4 LEU A 273
LEU A 195
GLY A 194
GLU A 193
 None
 1.13A 5hhjA-3ib3A:
undetectable		 5hhjA-3ib3A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 GLY A 206
LEU A 457
HIS A 476
 None
 0.65A 5u63A-3ib3A:
undetectable		 5u63A-3ib3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		3 / 3 GLY A 206
LEU A 457
HIS A 476
 None
 0.67A 5u63B-3ib3A:
undetectable		 5u63B-3ib3A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 496
GLU A 510
VAL A 511
GLU A 517
GLY A 521
 None
 1.33A 5xiqD-3ib3A:
undetectable		 5xiqD-3ib3A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_HFGA603_0
(UNCHARACTERIZED
PROTEIN)		 3ib3 COCE/NOND FAMILY
HYDROLASE
(Staphylococcus
aureus) 		5 / 12 LEU A 496
GLU A 510
VAL A 511
GLU A 517
GLY A 521
 None
 1.36A 6mn8A-3ib3A:
undetectable		 6mn8A-3ib3A:
21.56