SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ibj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 PHE A 404
LEU A 396
ALA A 400
ILE A 515
ILE A 542
None
1.15A 1crbA-3ibjA:
undetectable
1crbA-3ibjA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ILE A 279
ASN A 351
GLY A 280
LEU A 250
None
0.92A 1dzmA-3ibjA:
undetectable
1dzmA-3ibjA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZM_A_BZMA600_0
(ODORANT-BINDING
PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ILE A 546
ASN A 511
ASN A 509
GLY A 545
None
0.93A 1dzmA-3ibjA:
undetectable
1dzmA-3ibjA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 THR A 768
ASP A 697
HIS A 656
HIS A 660
MG  A 905 (-4.3A)
ZN  A   1 ( 2.9A)
None
ZN  A   1 (-3.4A)
1.02A 1ei6D-3ibjA:
undetectable
1ei6D-3ibjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 VAL A 399
LEU A 396
ILE A 417
ALA A 421
LEU A 424
None
1.07A 1eqgA-3ibjA:
undetectable
1eqgA-3ibjA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 VAL A 399
LEU A 396
ILE A 417
ALA A 421
LEU A 424
None
1.08A 1eqgB-3ibjA:
undetectable
1eqgB-3ibjA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 TYR A 655
LEU A 770
LEU A 809
GLN A 859
PHE A 862
None
0.72A 1tbfA-3ibjA:
38.4
1tbfA-3ibjA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA472_1
(CYTOCHROME P450 51)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 6 MET A 694
LEU A 738
PHE A 746
MET A 761
None
1.08A 1x8vA-3ibjA:
undetectable
1x8vA-3ibjA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_A_CIOA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
HIS A 700
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.99A 1xlxA-3ibjA:
32.5
1xlxA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLX_B_CIOB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
HIS A 700
ILE A 826
GLN A 859
PHE A 862
None
0.68A 1xlxB-3ibjA:
32.4
1xlxB-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_A_ROFA101_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.95A 1xmuA-3ibjA:
32.6
1xmuA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XMU_B_ROFB102_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
None
None
ZN  A   1 (-2.7A)
None
None
0.68A 1xmuB-3ibjA:
32.6
1xmuB-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
None
1.00A 1xomA-3ibjA:
32.5
1xomA-3ibjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
1.04A 1xomB-3ibjA:
32.8
1xomB-3ibjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_A_ROFA502_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.95A 1xoqA-3ibjA:
32.5
1xoqA-3ibjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOQ_B_ROFB501_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.98A 1xoqB-3ibjA:
32.7
1xoqB-3ibjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
GLN A 859
PHE A 862
ILE A 866
None
None
ZN  A   1 (-2.7A)
None
None
None
0.54A 1xosA-3ibjA:
32.7
1xosA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
PHE A 862
ILE A 866
None
None
ZN  A   1 (-2.7A)
None
None
None
0.74A 1xosA-3ibjA:
32.7
1xosA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOS_A_VIAA1_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
HIS A 660
GLN A 859
PHE A 862
ILE A 866
None
ZN  A   1 (-3.4A)
None
None
None
1.49A 1xosA-3ibjA:
32.7
1xosA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_A_VDNA101_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
7 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 826
GLN A 859
PHE A 862
ILE A 866
None
0.71A 1xotA-3ibjA:
32.7
1xotA-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOT_B_VDNB102_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4B)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.85A 1xotB-3ibjA:
32.8
1xotB-3ibjA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
ILE A 822
ILE A 855
GLN A 859
PHE A 862
None
0.86A 1xozA-3ibjA:
38.3
1xozA-3ibjA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AYL_A_FLPA1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 VAL A 399
LEU A 403
LEU A 396
ALA A 421
LEU A 424
None
1.08A 2aylA-3ibjA:
1.0
2aylA-3ibjA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 655
HIS A 656
ILE A 855
GLN A 859
PHE A 862
None
0.61A 2h42A-3ibjA:
38.3
2h42A-3ibjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
HIS A 656
ILE A 855
GLN A 859
PHE A 862
None
0.58A 2h42B-3ibjA:
38.8
2h42B-3ibjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
LEU A 770
LEU A 809
ILE A 855
PHE A 862
None
0.58A 2h42C-3ibjA:
38.5
2h42C-3ibjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_2
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
3 / 3 ASN A 599
ILE A 596
MET A 622
None
0.81A 2h42C-3ibjA:
38.5
2h42C-3ibjA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ASP A 811
TRP A 895
TYR A 655
TYR A 719
None
1.25A 2ha2A-3ibjA:
2.1
2ha2A-3ibjA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0I_A_BEZA990_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ASP A 808
ASP A 697
HIS A 660
SER A 665
ZN  A   1 (-2.7A)
ZN  A   1 ( 2.9A)
ZN  A   1 (-3.4A)
None
1.08A 2q0iA-3ibjA:
undetectable
2q0iA-3ibjA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q0J_A_BEZA500_0
(QUINOLONE SIGNAL
RESPONSE PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 10 ASP A 808
HIS A 656
ASP A 697
GLU A 727
LEU A 770
ZN  A   1 (-2.7A)
None
ZN  A   1 ( 2.9A)
None
None
1.22A 2q0jA-3ibjA:
undetectable
2q0jA-3ibjA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6F_C_010C6_0
(INFECTIOUS
BRONCHITIS VIRUS
(IBV) MAIN PROTEASE
N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
3 / 3 ASN A 704
LEU A 718
HIS A 656
None
0.84A 2q6fB-3ibjA:
undetectable
2q6fB-3ibjA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_E_ASDE1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 PHE A 505
LEU A 403
LEU A 414
ALA A 421
ALA A 518
None
1.30A 2vcvE-3ibjA:
undetectable
2vcvE-3ibjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_H_ASDH1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 PHE A 505
LEU A 403
LEU A 414
ALA A 421
ALA A 518
None
1.27A 2vcvH-3ibjA:
undetectable
2vcvH-3ibjA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
8 / 12 HIS A 656
LEU A 770
LEU A 809
ILE A 826
TYR A 827
GLU A 829
GLN A 859
PHE A 862
None
0.77A 2weyA-3ibjA:
36.6
2weyA-3ibjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
8 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 826
TYR A 827
GLU A 829
GLN A 859
PHE A 862
None
0.72A 2weyA-3ibjA:
36.6
2weyA-3ibjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 LEU A 623
VAL A 646
PHE A 746
MET A 757
None
0.93A 2weyB-3ibjA:
36.4
2weyB-3ibjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_B_EV1B1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 8 LEU A 770
ILE A 826
TYR A 827
GLN A 859
PHE A 862
None
0.78A 2weyB-3ibjA:
36.4
2weyB-3ibjA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
LEU A 809
ILE A 855
GLN A 859
PHE A 862
None
0.85A 3b2rA-3ibjA:
36.7
3b2rA-3ibjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 655
HIS A 656
LEU A 809
GLN A 859
PHE A 862
None
0.68A 3b2rB-3ibjA:
36.7
3b2rB-3ibjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_B_VDNB1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 655
HIS A 656
LEU A 809
ILE A 855
PHE A 862
None
0.60A 3b2rB-3ibjA:
36.7
3b2rB-3ibjA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DDY_A_RBFA187_1
(LUMAZINE PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 VAL A 577
CYH A 643
ILE A 745
ASP A 635
ILE A 619
None
1.08A 3ddyA-3ibjA:
undetectable
3ddyA-3ibjA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_B_ROFB902_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
PHE A 862
None
None
ZN  A   1 (-2.7A)
None
None
None
0.92A 3g4lB-3ibjA:
32.7
3g4lB-3ibjA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_C_ROFC903_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
None
None
ZN  A   1 (-2.7A)
None
None
0.72A 3g4lC-3ibjA:
32.5
3g4lC-3ibjA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G4L_D_ROFD904_0
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
6 / 12 TYR A 655
HIS A 656
ASP A 808
LEU A 809
ILE A 826
GLN A 859
None
None
ZN  A   1 (-2.7A)
None
None
None
0.93A 3g4lD-3ibjA:
32.8
3g4lD-3ibjA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IAK_A_EV1A415_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 TYR A 655
ILE A 826
GLN A 859
PHE A 862
ILE A 866
None
0.68A 3iakA-3ibjA:
32.0
3iakA-3ibjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 TYR A 655
HIS A 656
LEU A 770
GLN A 859
PHE A 862
None
0.67A 3jwqA-3ibjA:
38.5
3jwqA-3ibjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 655
HIS A 656
LEU A 770
GLN A 859
PHE A 862
None
0.68A 3jwqB-3ibjA:
38.5
3jwqC-3ibjA:
38.4
3jwqB-3ibjA:
21.08
3jwqC-3ibjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 7 TYR A 655
HIS A 656
GLN A 859
PHE A 862
None
0.33A 3jwqC-3ibjA:
38.4
3jwqC-3ibjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_D_VIAD901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 11 TYR A 655
HIS A 656
LEU A 770
GLN A 859
PHE A 862
None
0.69A 3jwqA-3ibjA:
38.5
3jwqD-3ibjA:
38.4
3jwqA-3ibjA:
21.08
3jwqD-3ibjA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N58_A_ADNA500_2
(ADENOSYLHOMOCYSTEINA
SE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 THR A 703
GLU A 727
THR A 768
HIS A 696
None
None
MG  A 905 (-4.3A)
ZN  A   1 (-3.5A)
1.36A 3n58A-3ibjA:
undetectable
3n58A-3ibjA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_A_NPSA5_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 VAL A 399
LEU A 403
LEU A 396
ALA A 421
LEU A 424
None
1.00A 3nt1A-3ibjA:
undetectable
3nt1A-3ibjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NT1_B_NPSB4_1
(PROSTAGLANDIN-ENDOPE
ROXIDE SYNTHASE 2)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 VAL A 399
LEU A 403
LEU A 396
ALA A 421
LEU A 424
None
1.00A 3nt1B-3ibjA:
undetectable
3nt1B-3ibjA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RD0_A_EDPA175_1
(FERRITIN LIGHT CHAIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 6 LEU A 671
TYR A 672
ALA A 601
LEU A 677
None
1.11A 3rd0A-3ibjA:
undetectable
3rd0A-3ibjA:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_A_PNXA902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 9 TYR A 655
LEU A 809
ILE A 826
GLN A 859
PHE A 862
None
0.76A 3tvxA-3ibjA:
33.1
3tvxA-3ibjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 7 TYR A 655
ILE A 826
GLN A 859
PHE A 862
None
0.59A 3tvxB-3ibjA:
33.0
3tvxB-3ibjA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
3 / 3 ASP A 769
GLU A 722
GLY A 723
None
0.66A 3w9tA-3ibjA:
undetectable
3w9tA-3ibjA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_D_CAMD502_0
(CAMPHOR
5-MONOOXYGENASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 PHE A 370
LEU A 250
THR A 257
VAL A 365
None
0.94A 3wrkD-3ibjA:
undetectable
3wrkD-3ibjA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C49_B_HCYB1384_1
(CORTICOSTEROID-BINDI
NG GLOBULIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 SER A 541
THR A 405
SER A 551
PHE A 404
HIS A 406
None
1.45A 4c49B-3ibjA:
undetectable
4c49B-3ibjA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ASP A 356
CYH A 325
GLU A 326
GLU A 354
None
0.96A 4gkhD-3ibjA:
undetectable
4gkhD-3ibjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKI_G_KANG301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ASP A 360
ASP A 310
ASP A 302
GLU A 363
None
1.15A 4gkiE-3ibjA:
undetectable
4gkiG-3ibjA:
undetectable
4gkiE-3ibjA:
17.70
4gkiG-3ibjA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HDL_A_DXCA75_0
(PPCA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ILE A 765
ILE A 735
MET A 645
GLY A 649
None
0.87A 4hdlA-3ibjA:
undetectable
4hdlA-3ibjA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JVL_A_ESTA702_1
(ESTROGEN
SULFOTRANSFERASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 9 PHE A 642
CYH A 643
PHE A 687
ILE A 629
None
0.86A 4jvlA-3ibjA:
undetectable
4jvlA-3ibjA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_A_ADNA501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.19A 4lvcA-3ibjA:
undetectable
4lvcA-3ibjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_C_ADNC501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.21A 4lvcC-3ibjA:
undetectable
4lvcC-3ibjA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 10 PHE A 707
PHE A 831
THR A 703
GLU A 727
TYR A 719
None
1.26A 4qb9A-3ibjA:
0.0
4qb9A-3ibjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_E_PARE500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 PHE A 707
PHE A 831
THR A 703
GLU A 727
TYR A 719
None
1.26A 4qb9E-3ibjA:
undetectable
4qb9E-3ibjA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_C_ASCC501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 LEU A 639
ILE A 619
ILE A 634
ILE A 691
PHE A 687
None
1.19A 4rp8C-3ibjA:
1.4
4rp8C-3ibjA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H8T_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 PHE A 404
LEU A 396
ALA A 400
ILE A 515
ILE A 542
None
1.16A 5h8tA-3ibjA:
undetectable
5h8tA-3ibjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HBS_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 PHE A 404
LEU A 396
ALA A 400
ILE A 515
ILE A 542
None
1.09A 5hbsA-3ibjA:
undetectable
5hbsA-3ibjA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JM4_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 PHE A 731
ILE A 735
MET A 761
ARG A 762
None
0.82A 5jm4A-3ibjA:
3.4
5jm4A-3ibjA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_2
(PROSTAGLANDIN G/H
SYNTHASE 2)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 4 LEU A 738
ARG A 641
ILE A 737
PHE A 642
None
1.12A 5kirB-3ibjA:
undetectable
5kirB-3ibjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_1
(MINERALOCORTICOID
RECEPTOR)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 6 GLN A 463
PHE A 433
THR A 499
PHE A 487
None
1.22A 5mwyA-3ibjA:
undetectable
5mwyA-3ibjA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEK_B_AZMB302_1
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 8 ASP A 697
HIS A 656
ARG A 728
HIS A 730
ZN  A   1 ( 2.9A)
None
None
None
0.99A 5nekB-3ibjA:
undetectable
5nekB-3ibjA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TQR_B_SAMB8009_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2, POLYCOMB
PROTEIN SUZ12)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 10 LEU A 231
CYH A 234
GLY A 235
TYR A 238
VAL A 376
None
1.48A 5tqrB-3ibjA:
3.0
5tqrB-3ibjA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
3 / 3 PHE A 777
ASP A 779
LEU A 766
None
0.76A 5uhcC-3ibjA:
undetectable
5uhcC-3ibjA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 LEU A 284
GLY A 324
CYH A 325
GLN A 320
LEU A 308
None
1.28A 5y2tA-3ibjA:
undetectable
5y2tA-3ibjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
5 / 12 SER A 665
LEU A 623
ILE A 686
LEU A 698
TYR A 650
None
1.34A 5ycpA-3ibjA:
undetectable
5ycpA-3ibjA:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F8C_A_STRA502_1
(CYTOCHROME P450
CYP260A1)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 6 SER A 260
THR A 257
ILE A 366
PHE A 370
None
0.82A 6f8cA-3ibjA:
undetectable
6f8cA-3ibjA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_A_ADNA501_2
(-)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.23A 6gbnA-3ibjA:
undetectable
6gbnA-3ibjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_D_ADND501_2
(-)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
4 / 5 GLN A 875
THR A 805
HIS A 773
LEU A 780
None
1.24A 6gbnD-3ibjA:
undetectable
6gbnD-3ibjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_3
(-)
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo
sapiens)
3 / 3 ASP A 683
ASP A 625
ASN A 599
None
0.86A 6gngB-3ibjA:
undetectable
6gngB-3ibjA:
21.79