SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '3ibr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_A_ACTA3003_0
(BETA-CARBONIC
ANHYDRASE)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 158
VAL A 160
HIS A 278
GLY A 156
 None
 0.87A 1ekjA-3ibrA:
undetectable
1ekjB-3ibrA:
undetectable		 1ekjA-3ibrA:
17.32
1ekjB-3ibrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 4 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.70A 1fbmD-3ibrA:
undetectable		 1fbmD-3ibrA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 5 THR A 140
LEU A 144
VAL A 147
LEU A 151
 None
 0.68A 1fbmE-3ibrA:
undetectable		 1fbmE-3ibrA:
6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1N_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		5 / 11 VAL A  64
GLY A  65
THR A  88
VAL A  86
VAL A  97
 None
 1.20A 2a1nA-3ibrA:
undetectable		 2a1nA-3ibrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_F_CSCF1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		3 / 3 LEU A 151
MET A 154
MET A 279
 None
 1.06A 2vavF-3ibrA:
undetectable		 2vavF-3ibrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VAV_L_CSCL1383_2
(ACETYL-COA--DEACETYL
CEPHALOSPORIN C
ACETYLTRANSFERASE)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 4 THR A 155
LEU A 151
MET A 154
MET A 279
 None
 1.27A 2vavL-3ibrA:
0.0		 2vavL-3ibrA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YS6_A_GLYA431_0
(PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 8 ASP A 194
TYR A 163
GLY A 171
PRO A 191
 BLA  A 900 (-3.4A)
BLA  A 900 (-4.6A)
None
None
 0.85A 2ys6A-3ibrA:
undetectable		 2ys6A-3ibrA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA424_0
(FERROCHELATASE,
MITOCHONDRIAL)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 8 LEU A 356
ARG A 362
PRO A 342
GLY A 337
 None
 1.04A 3hcrA-3ibrA:
undetectable		 3hcrA-3ibrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 6 HIS A 247
HIS A 277
SER A 275
ASP A 169
 BLA  A 900 (-3.8A)
BLA  A 900 (-4.2A)
BLA  A 900 (-2.9A)
None
 1.40A 4blvA-3ibrA:
undetectable		 4blvA-3ibrA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_B_RTLB201_0
(RETINOL-BINDING
PROTEIN 2)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		5 / 12 ILE A 481
ARG A 321
LEU A 349
LEU A 492
LEU A 489
 None
 1.38A 4qynB-3ibrA:
undetectable		 4qynB-3ibrA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3U_B_SVRB102_1
(CHROMOBOX PROTEIN
HOMOLOG 7)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		3 / 3 LYS A 282
ARG A 159
VAL A 160
 None
 0.92A 4x3uA-3ibrA:
undetectable
4x3uB-3ibrA:
undetectable		 4x3uA-3ibrA:
8.24
4x3uB-3ibrA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		5 / 10 ASP A 139
ALA A 162
VAL A 174
SER A 142
SER A 145
 None
 1.12A 4xp1A-3ibrA:
undetectable		 4xp1A-3ibrA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZME_A_ADNA1002_1
(MYOSIN HEAVY CHAIN
KINASE A)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		5 / 11 GLY A  50
VAL A  38
LEU A  72
LEU A 108
PHE A 110
 None
 1.05A 4zmeA-3ibrA:
undetectable		 4zmeA-3ibrA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 6 ARG A 189
GLY A 187
GLU A 172
ARG A 457
 None
 1.10A 5btaA-3ibrA:
undetectable
5btaB-3ibrA:
undetectable
5btaC-3ibrA:
undetectable		 5btaA-3ibrA:
22.20
5btaB-3ibrA:
18.57
5btaC-3ibrA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_E_MFXE2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 189
GLY A 187
GLU A 172
ARG A 457
 None
 1.12A 5cdqA-3ibrA:
undetectable
5cdqB-3ibrA:
undetectable
5cdqC-3ibrA:
undetectable		 5cdqA-3ibrA:
22.38
5cdqB-3ibrA:
16.70
5cdqC-3ibrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_V_MFXV2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 5 ARG A 189
GLY A 187
GLU A 172
ARG A 457
 None
 1.13A 5cdqR-3ibrA:
undetectable
5cdqS-3ibrA:
undetectable
5cdqT-3ibrA:
undetectable		 5cdqR-3ibrA:
22.38
5cdqS-3ibrA:
16.70
5cdqT-3ibrA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		5 / 12 GLN A  24
VAL A 243
HIS A 247
LEU A 251
VAL A 256
 None
BLA  A 900 ( 3.8A)
BLA  A 900 (-3.8A)
None
None
 1.22A 5i8fA-3ibrA:
undetectable		 5i8fA-3ibrA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		5 / 9 ILE A 195
PRO A 196
VAL A 214
LEU A 251
TYR A 190
 BLA  A 900 (-4.2A)
BLA  A 900 (-4.4A)
None
None
BLA  A 900 (-1.9A)
 1.30A 5iepA-3ibrA:
undetectable		 5iepA-3ibrA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 5 ALA A  41
ALA A  53
ILE A  45
LEU A  49
 None
 0.74A 5jncD-3ibrA:
undetectable		 5jncD-3ibrA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NN8_A_ACRA1016_1
(LYSOSOMAL
ALPHA-GLUCOSIDASE)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 5 ASP A 194
GLY A 171
PRO A 191
TRP A 463
 BLA  A 900 (-3.4A)
None
None
None
 1.16A 5nn8A-3ibrA:
undetectable		 5nn8A-3ibrA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_A_TESA504_1
(-)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 8 VAL A  68
ILE A  90
ALA A  28
LEU A 108
 None
 0.78A 5og9A-3ibrA:
undetectable		 5og9A-3ibrA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0C_D_TA1D502_1
(TUBULIN BETA CHAIN)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		5 / 12 LEU A  32
LEU A  72
LEU A 108
GLY A  50
LEU A  49
 None
 0.89A 6b0cD-3ibrA:
undetectable		 6b0cD-3ibrA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_B_RFPB502_2
(RIFAMPIN
MONOOXYGENASE)		 3ibr BACTERIOPHYTOCHROME
(Pseudomonas
aeruginosa) 		4 / 6 VAL A 303
MET A 154
ARG A 289
PRO A 207
 None
 1.31A 6brdB-3ibrA:
undetectable		 6brdB-3ibrA:
9.56